A5007710074- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Brain Tumor Detection and Classification
- Fetal and Pediatric Neurological Disorders
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- NMR spectroscopy and applications
- Management of metastatic bone disease
- Transcranial Magnetic Stimulation Studies
- Electronic Packaging and Soldering Technologies
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Radiotherapy Techniques
- Medical Imaging and Analysis
- Neuroscience and Music Perception
- Neurogenesis and neuroplasticity mechanisms
- Otolaryngology and Infectious Diseases
- Neuroscience and Neuropharmacology Research
Heidelberg University
2025
University Hospital Heidelberg
2025
Amsterdam University Medical Centers
2024-2025
University Medical Center Utrecht
2017-2025
Ghent University
2024
Utrecht University
2018-2024
St Helens and Knowsley Teaching Hospitals NHS Trust
2023
University Medical Center
2021
Australian Catholic University
2020
Ghent University Hospital
2020
Abstract Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, approach has not been systematically validated in ground truth studies. Based a simulated data set with tracts, we organized an open international tractography challenge, which resulted 96 distinct submissions from 20 research groups. Here, report encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% bundles (to at least some...
Abstract Fiber tractography based on non-invasive diffusion imaging is at the heart of connectivity studies human brain. To date, approach has not been systematically validated in ground truth studies. Based a simulated brain dataset with white matter tracts, we organized an open international challenge, which resulted 96 distinct submissions from 20 research groups. While most state-of-the-art algorithms reconstructed 90% bundles to least some extent, average they produced four times more...
Nonlinearities of gradient magnetic fields in diffusion MRI (dMRI) can introduce systematic errors estimates measures. While there are correction methods that compensate for these errors, as presented the Human Connectome Project, such nonlinear effects often assumed to be negligible typical applications, and a result, nonlinearities mostly left uncorrected. In this work, we perform analysis investigate effect on dMRI studies, from voxel-wise group study outcomes. We present novel framework...
Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), but its clinical efficacy remains rather modest. One reason this could be that the propagation of rTMS effects via structural connections from stimulated area to deeper brain structures (such as cingulate cortices) suboptimal.We investigated whether connectivity — derived diffusion MRI data serve a biomarker predict response. We hypothesized stronger between patient-specific...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
Fiber tractography (FT) using diffusion MRI (dMRI) is widely used for investigating microstructural properties of white matter (WM) fiber-bundles and mapping structural connections the human brain. While studying architectural configuration brain's circuitry with FT not without controversy, recent progress in acquisition, processing, modeling, analysis, visualization dMRI data pushes forward reliability reconstructing WM pathways. Despite being aware well-known pitfalls analyzing several...
With overall survival of brain tumors improving, radiation induced injury is becoming an increasing issue. One the effects therapy (RT) thinning cerebral cortex, which could be one factors contributing to cognitive impairments after treatment. In healthy brain, cortex thickness varies between 1 and 4.5 mm. this study, we assess effect RT on relate changes local dose.We identified 28 glioma patients with optimal scan quality. Clinical CTs MRIs at baseline year post-RT were collected...
Previous research using functional MRI identified brain regions associated with sensory processing sensitivity (SPS), a proposed normal phenotype trait. To further validate SPS, to characterize it anatomically, and test the usefulness in psychology of methodologies that assess axonal properties, present study correlated SPS proxy questionnaire scores (adjusted for neuroticism) diffusion tensor imaging (DTI) measures. Participants (n = 408) from Human Connectome Project were studied....
The orexigenic gut-brain peptide, ghrelin and its G-protein coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1A) are pivotal regulators of hypothalamic feeding centers reward processing neuronal circuits brain. These systems operate in a cooperative manner receive wide array hormone/transmitter messages metabolic signals. Functional magnetic resonance imaging was employed current study to map BOLD responses different brain regions with special reference on homeostatic...
Concordant results of functional magnetic resonance imaging (fMRI) and behavioral tests prove that some non-blood-brain barrier-penetrating drugs produce robust central nervous system (CNS) effects. The anticholinergic scopolamine interferes with learning when tested in rats, which coincides a negative blood-oxygen-level-dependent (BOLD) change the prefrontal cortex (PFC) as demonstrated by fMRI. peripherally acting butylscopolamine also evokes deficit water-labyrinth test provokes BOLD...
Abstract Aggression after military deployment is a common occurrence in veterans. Neurobiological research has shown that aggression associated with dysfunction network connecting brain regions implicated threat processing and emotion regulation. However, may also be related to deficits networks underlying communication social cognition. The uncinate arcuate fasciculi are integral these networks, thus studying potential abnormalities white matter connections can further our understanding of...
Manual segmentation of medical images is labor intensive and especially challenging for with poor contrast or resolution. The presence disease exacerbates this further, increasing the need an automated solution. To extent, SynthSeg a robust deep learning model designed automatic brain across various contrasts resolutions. This study validates on computed tomography (CT), using multi-center dataset. An open access dataset 260 paired CT magnetic resonance imaging (MRI) from radiotherapy...
Abstract Background and purpose Radiation-induced changes in brain tissue may relate to post-radiotherapy (RT) cognitive decline. Our aim is investigate of the microstructural properties after exposure radiation during clinical protocols RT using diffusion MRI (dMRI). Methods Materials The susceptibility was investigated a clinically heterogenic cohort (age, pathology, tumor location, type surgery) consisting 121 scans 18 patients (10 females). imaging dataset included planning CTs 103 dMRI...
There is a huge unmet need to understand and treat pathological cognitive impairment. The development of disease modifying enhancers hindered by the lack correct pathomechanism suitable animal models. Most models study cognition pathology do not fulfil either predictive validity, face validity or construct criteria, also outcome measures greatly differ from those human trials. Fortunately, some pharmacological agents such as scopolamine evoke similar effects on cerebral circulation in...
Numerous brain MR imaging studies have been performed to understand radiation-induced cognitive decline. However, many of them focus on a single region interest, e.g. cerebral cortex or hippocampus. In this study, we use deformation-based morphometry (DBM) and voxel-based (VBM) measure the morphological changes in patients receiving fractionated photon RT, relate these dose. Additionally, study tissue specific volume white matter (WM), grey (GM), cerebrospinal fluid total intracranial (TIV).
Neural stem cells in the subventricular zone (SVZ) and subgranular (SGZ) are hypothesized to support growth of glioma. Therefore, irradiation SVZ SGZ might reduce tumor improve overall survival (OS). However, it may also inhibit repair capacity brain tissue. The aim this retrospective cohort study is assess impact radiotherapy doses on OS patients with high-grade (HGG) or low-grade (LGG)
Diffusion weighted magnetic resonance imaging is increasingly being used for neonatal and young pediatric subjects. Our purpose was to investigate a) whether cardiac triggering needed reduce variability of diffusion (tensor) data, b) how pulsation artifacts affect the fitted tensor when not c) feasibility triggered data acquisition in neonates children. Data were collected from 11 infants 7 adults. In seven adults, encoding applied solely along z gradient direction with without triggering....
Abstract Background and purpose The relation between radiotherapy (RT) dose to the brain morphological changes in healthy tissue has seen recent increased interest. There already is evidence for cerebral cortex white matter, as well selected subcortical grey matter (GM) structures. We studied this all deep GM structures, help understand aetiology of post-RT neurocognitive symptoms. Materials methods 31 patients treated with RT glioma. Pre-RT 3D T1 MRIs were automatically segmented, volume...