A5091794967- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Mental Health Research Topics
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Mindfulness and Compassion Interventions
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Prenatal Substance Exposure Effects
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Receptor Mechanisms and Effects
- Memory and Neural Mechanisms
- Health, Environment, Cognitive Aging
- Aldose Reductase and Taurine
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Mind wandering and attention
- Neuroscience of respiration and sleep
University of Pennsylvania
2018-2024
California University of Pennsylvania
2024
Research Network (United States)
2023-2024
Translational Therapeutics (United States)
2018-2022
National Institute on Drug Abuse
2016-2020
Cognitive Neuroimaging Lab
2014
Duke University
2011
Significance The default mode network (DMN) has been suggested to support a variety of internal-state functions in human. Because preclinical models can be used translational studies neuropsychiatric disorders, investigations the DMN these may aid understanding both physiology and pathophysiology human DMN. To our knowledge, this is first study investigate constituents functional implications rat We provide empirical evidence that composed highly connected anatomical subnetworks, which show...
Mindful attention is characterized by acknowledging the present experience as a transient mental event. Early stages of mindfulness practice may require greater neural effort for later efficiency. self-regulate behavior and focalize present, but this understanding lacks computational explanation. Here we used network control theory model how external inputs—operationalizing effort—distribute changes in activity evoked during mindful across white matter network. We hypothesized that...
Resting-state magnetic resonance imaging (rsMRI) is thought to reflect ongoing spontaneous brain activity. However, the precise neurophysiological basis of rsMRI signal remains elusive. Converging evidence supports notion that local field potential (LFP) in high-frequency range correlates with fMRI response evoked by a task (e.g., visual stimulation). It uncertain whether this relationship extends rsMRI. In study, we systematically modulated LFP whisker barrel cortex (WBC) unilateral...
Significance Cigarette smoking is the leading cause of preventable disease and death in United States. Severe withdrawal symptoms are reason most people have a hard time quitting smoking. AMP-activated protein kinase (AMPK) master regulator energy homeostasis activated response to cellular stressors. We discovered that AMPK pathway following chronic nicotine use but repressed withdrawal. reasoned increasing pAMPK levels pharmacologically might reduce After giving mice metformin, an...
Significance Persistent alterations to neural circuitry may help explain why opiate abuse liability is higher among individuals with a history of chronic exposure. In this study, we employ unique combination computational approaches understand how opiate-induced reorganization network connectivity supported by transcriptional and structural features the brain. We identify persistent reduction in FOS correlation strength following dependence determine that correlated gene expression...
Introduction Infants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid Withdrawal Syndrome (NOWS), a combination somatic withdrawal symptoms including pitched crying, sleeplessness, irritability, gastrointestinal distress, and the worst cases, seizures. The heterogeneity opioid exposure, particularly exposure polypharmacy, makes it difficult investigate underlying molecular mechanisms that could inform early diagnosis treatment NOWS, challenging consequences later...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). These mutations elevate LRRK2 activity, making inhibitors an attractive therapeutic. activity has been consistently linked to specific cell signaling pathways, mostly related organelle trafficking and homeostasis, but its relationship PD pathogenesis more difficult define. LRRK2-PD patients present with loss dopaminergic neurons substantia nigra show variable development Lewy...
Abstract Opioid use among pregnant women is a growing public health concern in the United States. Infants exposed to opioids utero are at risk of exhibiting neonatal opioid withdrawal syndrome (NOWS). The biological mechanisms underlying short and long‐term consequences exposure NOWS unknown. A potential genetic factor single‐nucleotide polymorphism (SNP) mu‐opioid receptor gene ( OPRM1 A118G). infants with G‐allele spend less time hospitals after birth. To determine whether this SNP...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
Network control theory (NCT) is a simple and powerful tool for studying how network topology informs constrains dynamics. Compared to other structure-function coupling approaches, the strength of NCT lies in its capacity predict patterns external signals that may alter dynamics desired way. We have extensively developed validated application human structural connectome. Through these efforts, we studied (i) different aspects connectome affect neural dynamics, (ii) whether outputs cohere with...
Although 60% of the US population have tried smoking cigarettes, only 16% smoke regularly. Identifying this susceptible subset before onset nicotine dependence may encourage targeted early interventions to prevent regular and/or minimize severity. While prospective neuroimaging in human populations can be challenging, preclinical models chronic administration help develop translational biomarkers disease risk. Chronic, intermittent (0, 1.2, or 4.8 mg/kg/d;
Risk is a ubiquitous feature of the environment for most organisms, who must often choose between small and certain reward larger but less reward. To study choice behavior under risk in genetically well characterized species, we trained mice (C57BL/6) on discrete trial, concurrent-choice task which they two levers. Pressing one lever (safe choice) always followed by other (risky reward, only some trials. The overall payoff same both When were not food deprived, indifferent to risk, choosing...
ABSTRACT α-Synuclein misfolding and progressive accumulation drives a pathogenic process in Parkinson’s disease. To understand cellular network vulnerability to α-synuclein pathology, we developed framework quantify network-level identify new therapeutic targets at the level. Full brain pathology was mapped mice over 9 months. Empirical data compared theoretical estimates from diffusion model of progression along anatomical connections. Unexplained variance enabled us derive regional that...
Opioid use disorder is a chronic, relapsing disease associated with persistent changes in brain plasticity. A common single nucleotide polymorphism (SNP) the µ-opioid receptor gene,
Genetic and environmental factors contribute to an individual's sensitivity drug reward aversion, thereby influencing their susceptibility abuse addiction. A genetic variant (D398N) in the gene CHRNA5 , which encodes α5 subunit of nicotinic acetylcholine receptor (nAChR