A5091973419- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- 3D Printing in Biomedical Research
- bioluminescence and chemiluminescence research
- Nuclear Receptors and Signaling
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Neurological and metabolic disorders
Van Andel Institute
2023-2024
Research Network (United States)
2023-2024
Abstract A key hallmark of Parkinson’s disease (PD) is Lewy pathology. Composed α-synuclein, pathology found both in dopaminergic neurons that modulate motor function, and cortical regions control cognitive function. Recent work has established the molecular identity susceptible to death, but little known about or changes induced by aggregates. In current study, we use spatial transcriptomics capture whole transcriptome signatures from with α-synuclein compared without We find, PD related...
Parkinson's disease (PD) is the second most common neurodegenerative worldwide and presents pathologically with Lewy pathology dopaminergic neurodegeneration. contains aggregated α-synuclein (αSyn), a protein encoded by SNCA gene which also mutated or duplicated in subset of familial PD cases. Due to its predominant presynaptic localization, immunostaining for results diffuse reactivity pattern, providing little insight into types cells expressing αSyn. As result, αSyn expression-driven...
Abstract Lewy pathology composed of α-synuclein is the key pathological hallmark Parkinson’s disease (PD), found both in dopaminergic neurons that control motor function, and throughout cortical regions cognitive function. Recent work has investigated which are most susceptible to death, but little known about vulnerable developing what molecular changes an aggregate induces. In current study, we use spatial transcriptomics selectively capture whole transcriptome signatures from with...
ABSTRACT α-Synuclein misfolding and progressive accumulation drives a pathogenic process in Parkinson’s disease. To understand cellular network vulnerability to α-synuclein pathology, we developed framework quantify network-level identify new therapeutic targets at the level. Full brain pathology was mapped mice over 9 months. Empirical data compared theoretical estimates from diffusion model of progression along anatomical connections. Unexplained variance enabled us derive regional that...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative worldwide and presents pathologically with Lewy pathology dopaminergic neuron loss. contains aggregated αSynuclein (αSyn), a protein encoded by SNCA gene which also mutated or duplicated in subset of familial PD cases. Due to its predominant presynaptic localization, immunostaining for results diffuse signal, providing little insight into types cells expressing αSyn. As result, αSyn expression-driven cellular...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative worldwide and presents pathologically with Lewy pathology dopaminergic neuron loss. contains aggregated ⍺Synuclein (⍺Syn), a protein encoded by SNCA gene which also mutated or duplicated in subset of familial PD cases. Due to its predominant presynaptic localization, immunostaining for results diffuse parenchymal reactivity, providing little insight into types cells expressing ⍺Syn. As result, ⍺Syn expression...