A5036052976- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Peripheral Neuropathies and Disorders
- Macrophage Migration Inhibitory Factor
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Glioma Diagnosis and Treatment
- RNA regulation and disease
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Fibroblast Growth Factor Research
- Inflammatory mediators and NSAID effects
- Nuclear Receptors and Signaling
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Advanced X-ray Imaging Techniques
- Brain Metastases and Treatment
- Advanced Neuroimaging Techniques and Applications
- Cancer, Lipids, and Metabolism
Universitätsmedizin Göttingen
2016-2025
University of Göttingen
2016-2025
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103
2011-2025
Heinrich Heine University Düsseldorf
2007-2024
Düsseldorf University Hospital
2024
Fraunhofer Institute for Translational Medicine and Pharmacology
2024
Research Network (United States)
2023-2024
University Medical Center
2016-2024
Max Planck Institute of Experimental Medicine
2019-2023
University of Basel
2021-2023
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome 2 (SARS-CoV-2). For many viruses, tissue tropism determined by availability virus receptors and entry cofactors on surface host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked a monoclonal blocking antibody against NRP1. A mutant with altered furin cleavage site did not depend...
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain patient's clinical deficits. We thus analysed global brain pathology sclerosis, focusing on normal-appearing matter (NAWM) and cortex. Autopsy tissue from 52 patients (acute, relapsing-remitting, primary secondary progressive sclerosis) 30 controls was using quantitative morphological techniques. New active focal inflammatory demyelinating lesions were mainly present...
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic disease. Moreover, thromboembolic events throughout the body, including in CNS, have been described. Given neurological symptoms observed large majority of individuals with SARS-CoV-2 penetrance CNS is likely. By various means, we demonstrate presence RNA and protein anatomically distinct regions nasopharynx brain. Furthermore, describe morphological changes associated infection such...
Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity during development after injury. In the nervous system, neurons are considered major cellular source of BDNF. We demonstrate here that in addition, activated human T cells, B monocytes secrete bioactive BDNF vitro. Notably, helper (Th)1- Th2-type CD4+ cell lines specific for myelin autoantigens such as basic protein or oligodendrocyte glycoprotein, production is increased upon antigen stimulation....
Although spontaneous remyelination does occur in multiple sclerosis lesions, its extent within the global population with this disease is presently unknown. We have systematically analysed incidence and distribution of completely remyelinated lesions (so-called shadow plaques) or partially (shadow plaque areas) 51 autopsies patients different clinical courses durations. The was variable between cases. In 20% patients, extensive 60-96% lesion area remyelinated. Extensive found not only...
The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO-IgGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in perivessel and subpial areas brain. Our objectives were to determine source central nervous system (CNS) NMO-IgGs their role disease pathogenesis.Fluorescence-activated cell sorting single-cell reverse transcriptase polymerase chain reaction used identify overrepresented plasma immunoglobulin (Ig) sequences...
Recent immunohistological and imaging studies emphasize the crucial role of axonal injury in determining extent permanent neurological deficits patients with multiple sclerosis. We have recently shown that human immune cells are capable producing neurotrophin brain‐derived neurotrophic factor (BDNF), which can prevent neuronal damage after various pathological insults. BDNF imported into CNS by would thus be an attractive candidate for mediating neuroprotective effects The aim present study...
It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in future. Consequently, order to reach a diagnosis of Alzheimer's disease (AD), presence hyperphosphorylated tau (HP-tau) and beta-amyloid protein brain tissue must be unequivocal. In addition, stepwise progression pathology needs assessed. This paper deals exclusively with regional assessment AD-related HP-tau pathology. The objective was provide straightforward instructions aid...
Neocortical demyelination in the forebrain has recently been identified as an important pathological feature of multiple sclerosis (MS). Here we describe that cerebellar cortex is a major predilection site for demyelination, particular patients with primary and secondary progressive MS. In these patients, on average, 38.7% cortical area affected, reaching extreme examples up to 92%. Cerebellar occurs mainly band‐like manner, affecting folia. The lesions are characterized by relative axonal...
Axonal degeneration is an initial key step in traumatic and neurodegenerative CNS disorders. We established a unique vivo epifluorescence imaging paradigm to characterize very early events axonal the rat optic nerve. Single retinal ganglion cell axons were visualized by AAV-mediated expression of dsRed this allowed quantification postlesional acute (AAD). EM analysis revealed severe structural alterations cytoskeleton, cytoplasmatic vacuolization, appearance autophagosomes within first hours...
When 22 members of the BrainNet Europe (BNE) consortium assessed 31 cases with α-synuclein (αS) immunoreactive (IR) pathology applying consensus protocol described by McKeith and colleagues in 2005, inter-observer agreement was 80%, being lowest limbic category (73%). staging Braak 2003, only 65%, some as low 36%. modifications these strategies, i.e., McKeith's Leverenz from 2009, Braak's Müller 2005 were applied then increased to 78 82%, respectively. In both modifications, a reduced number...
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS) that thought to be caused by a combination genetic and environmental factors. To date, considerable evidence has associated Epstein–Barr virus (EBV) infection with development. However, it remains controversial whether EBV infects multiple brain contributes directly CNS immunopathology. assess characteristic feature brain, large cohort specimens containing white matter lesions (nine adult three...
Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in of patients with COVID-19 elucidate potential mechanisms underlying the vascular pathology. In brains severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals animal models, found an increased number empty basement membrane tubes, so-called string representing remnants lost capillaries. We obtained evidence that brain...
BCAS1 expression identifies newly formed and actively myelinating oligodendrocytes in development, adulthood, disease.
The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing number studies suggest its presence neurons where putative functions remain controversial for more than a decade. To resolve this issue and to provide model analysis functions, we generated BAC transgenic mice that allow visualization functional EGFP-tagged receptors vivo. Extensive characterization these revealed dominant P2X7-EGFP protein expression microglia, Bergmann glia, oligodendrocytes, but not...