A5057889485- Neuroscience of respiration and sleep
- RNA Research and Splicing
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
German Centre for Cardiovascular Research
2021
University of Lübeck
2020-2021
Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in of patients with COVID-19 elucidate potential mechanisms underlying the vascular pathology. In brains severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals animal models, found an increased number empty basement membrane tubes, so-called string representing remnants lost capillaries. We obtained evidence that brain...
Carbon dioxide (CO2), the major product of metabolism, has a strong impact on cerebral blood vessels, phenomenon known as cerebrovascular reactivity. Several vascular risk factors such hypertension or diabetes dampen this response, making reactivity useful diagnostic marker for incipient pathology, but its functional relevance, if any, is still unclear. Here, we found that GPR4, an endothelial H+ receptor, and Gαq/11 proteins mediate CO2/H+ effect in mice. leads to constriction vessels...
Circular RNA is progressively reported to occur in various species including mammals where it thought be involved the post-transcriptional regulation of gene expression, partly via interactions with microRNA. Here, we asked whether circular topology causes functional differences linear forms when interacting short strands vitro and human cells. Kinetic studies bladder cancer-derived synthetic versus transcripts, respectively, oligoribonucleotides showed similar association rates for both...