A5016702147- Digital Mental Health Interventions
- Mental Health Research Topics
- Impact of Technology on Adolescents
- Attachment and Relationship Dynamics
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Health and Medical Studies
- Psychotherapy Techniques and Applications
- COVID-19 Clinical Research Studies
- Meat and Animal Product Quality
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- Psychology, Coaching, and Therapy
- Behavioral Health and Interventions
- Laser Applications in Dentistry and Medicine
- RNA and protein synthesis mechanisms
- Telemedicine and Telehealth Implementation
- Cardiovascular and Diving-Related Complications
- Psychosomatic Disorders and Their Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Musculoskeletal Disorders and Rehabilitation
- Bacterial Genetics and Biotechnology
- Psychiatric care and mental health services
- Psychological and Temporal Perspectives Research
University of Salzburg
2017-2022
University of Lübeck
2020-2021
Universität Hamburg
2018-2021
University of Cologne
2020
Roche (Switzerland)
2020
University Medical Center Hamburg-Eppendorf
2020
Inserm
2020
Verband der Privaten Krankenversicherung
2017
Donauspital
2009
Innsbruck Medical University
2009
Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in of patients with COVID-19 elucidate potential mechanisms underlying the vascular pathology. In brains severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals animal models, found an increased number empty basement membrane tubes, so-called string representing remnants lost capillaries. We obtained evidence that brain...
Weaning from mechanical ventilation was categorised as simple, difficult or prolonged by an international task force of the American Thoracic Society/European Respiratory Society Intensive Care Medicine/Society Critical Medicine/Sociéte de Réanimation Langue Française in 2007. This new classification has not been tested clinical practice. The objective present study to determine incidence and outcome weaning according categories. We included medical surgical patients who required a...
Web-based and blended (face-to-face plus Web-based) interventions for mental health disorders are gaining significance. However, many licensed psychotherapists still have guarded attitudes toward computer-assisted therapy, hindering dissemination efforts.The objective of this study was to provide a therapist-oriented evaluation therapies identify commonalities differences in both formats. Furthermore, it aimed test the impact an information clip on expressed attitudes.In total, 95 Austrian...
Therapists hold a key role for the uptake of digital mental health interventions (DMHI) within regular care services but have demonstrated cautious attitudes towards such interventions. It is relevant to explore in detail what factors may positively influence therapists' perception when considering DMHI implementation routine care. We recently assessed therapist views Internet-based and blended treatment Austria (low level). The present study aims at testing reliability previous findings,...
Abstract Three stop codons (UAA, UAG and UGA) terminate protein synthesis are almost exclusively recognized by release factors. Here, we design de novo transfer RNAs (tRNAs) that efficiently decode UGA in Escherichia coli . The tRNA designs harness various functionally conserved aspects of sense-codon decoding tRNAs. Optimization within the TΨC-stem to stabilize binding elongation factor, displays most potent effect enhancing suppression activity. We determine structure ribosome a complex...
Blended interventions aim to capitalise on the strengths of both computer-based and face-to-face therapy. Studies this innovative treatment format remain scare. This especially accounts for group depression.The present study applied eclectic psychotherapy methods an adult sample exhibiting a variety depressive symptoms (N = 46). Participants were recruited by newspaper inlet randomised either or waiting list condition. Computer supported components multimedia sessions, e-learning, online...
ABSTRACT This study examined the efficacy of Positive Psychotherapy (PPT) as an alternative approach to treatment depression and contrasted it with well-established Cognitive Behavioral Therapy (CBT). Ninety-two individuals who met DSM-IV criteria for a depressive disorder were randomly assigned either manualized group PPT or CBT. The primary outcome measures posttreatment 6-month follow-up changes in self-reported observer-rated depressiveness. secondary measure was general psychological...
This study investigated the feasibility of a novel blended (face-to-face and computer-based) group intervention for reduction depressive symptoms in major depression.Patient-centred uncontrolled interventional study.University setting general community sample. A multimodal recruitment strategy (public health centres public areas) was applied.Based on independent interviews, 26 participants, diagnosed with disorder (81% female; 23% comorbidity >1 >2), entered treatment.Acceptance mindfulness...
Blended group therapy combines sessions with Web- and mobile-based treatment modules. Consequently, blended widens the choice within interventions at reasonable costs. This is first qualitative study on therapy.The objective of this was to investigate patient-centered feasibility for major depression, special emphasis fit dynamic interplay between face-to-face internet-based elements.A total 22 patients who had a variety experiences through participating in one two were interviewed following...
Blended group therapy (bGT) has been investigated a several times for anxiety and depression, but information on patients' adherence to therapists' perception of the novel format is nonexistent. Furthermore, many studies mainly female highly educated populations, limiting validity previous findings.
Smartphone-based devices are increasingly recognized to assess disease symptoms in daily life (e.g. ecological momentary assessment, EMA). Despite this development digital psychiatry, clinical trials mainly based on point assessments of psychopathology. This study investigated expectable increases statistical power by intense assessment randomized controlled (RCTs). A simulation study, three scenarios and several empirical data sets, estimated gains two- or fivefold pre-post-assessment. For...
Abstract Several lines of evidence suggest that neurological symptoms in COVID-19 patients are partially due to damage small vessels. However, the potential mechanisms unclear. Here, we show brain endothelial cells express SARS-CoV-2 receptors. The main protease (M pro ) cleaves NEMO, essential modulator NF-κB signaling. By ablating M induces death human and a microvascular pathology mice is similar what find patients. Importantly, inhibition receptor-interacting protein kinase (RIPK) 3,...
It was recently shown that sampling of tissues with a picosecond infrared laser (PIRL) for analysis bottom-up proteomics is advantageous compared to mechanical homogenization. Because the cold ablation PIRL irradiation soft, proteins remain intact and even enzymatic activities are detectable in homogenates. In contrast, it observed microsecond (MIRL) heats tissue, thereby causing significant damage. this study, we investigated question if MIRL their proteomes via possible how results...
Die Verbreitung moderner Medien wirkt sich zunehmend auf psychologische Behandlungsangebote aus. Während die empirische Basis internetbasierter Interventionen zur Behandlung häufiger psychischer Beeinträchtigungen wächst und ihre Anwendung in der Regelversorgung gegenwärtig international erprobt wird, bestehen zusätzliche Bestrebungen, das gewonnene Knowhow mit konventioneller Psychotherapie zu kombinieren. daraus entstehende Behandlungsform "gemischten Psychotherapie" ("blended therapy")...
Colloidal approaches allow for the synthesis of Au nanoclusters (NCs) with atomic precision and sizes ranging from a few to hundreds atoms.
Zusammenfassung Hintergrund Kognitiv-behaviorale und psychodynamische Therapieverfahren befinden sich in einem Konkurrenzverhältnis, was den Nachweis ihrer Wirksamkeit angeht. Obwohl es bereits vergleichende Wirksamkeitsstudien gab, bilden diese oft nicht die Versorgungssituation Deutschland ab. Anfang des Jahres wurden Ergebnisse der „LAC-Depressionsstudie“ vorgelegt, beiden Verfahren naturalistischen Studiendesign vergleicht. Diese suggerieren gleiche Effektivität von kognitiver...
Es soll untersucht werden, zwischen welchen Ärzten ein besonders enger Kommunikationsbedarf besteht. Das betrifft die Identifikation von Ärzten, bei der Einführung Innovationen und im Hinblick auf Herausforderungen einer älter werdenden Bevölkerung zentraler Bedeutung sind. Als Handlungspotenzial sollen Defizite gegenüber vorhandenen Vernetzungen identifiziert werden. Multimorbidität Multimedikation sind für ältere Menschen hinsichtlich Risiken Bedeutung. Arzneimittelgruppen hohem...