A5050983886- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Immune cells in cancer
- Barrier Structure and Function Studies
- Fibroblast Growth Factor Research
- RNA Research and Splicing
- Bone and Joint Diseases
- Lymphatic System and Diseases
- Peroxisome Proliferator-Activated Receptors
- Axon Guidance and Neuronal Signaling
- MicroRNA in disease regulation
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Hereditary Neurological Disorders
- Spinal Dysraphism and Malformations
- Congenital heart defects research
- Retinal Development and Disorders
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Cellular transport and secretion
Universitätsmedizin Göttingen
2013-2025
University of Göttingen
2011-2023
Institute of Neuroimmunology of the Slovak Academy of Sciences
2021
BCAS1 expression identifies newly formed and actively myelinating oligodendrocytes in development, adulthood, disease.
Breakdown of myelin sheaths is a pathological hallmark several autoimmune diseases the nervous system. We employed autoantibody-mediated animal models demyelinating diseases, including rat model neuromyelitis optica (NMO), to target and found that lamellae are broken down into vesicular structures at innermost region sheath. demonstrated basic proteins (MBP), which form polymer in between membrane layers, targeted these models. Elevation intracellular Ca2+ levels resulted MBP network...
Abstract Objective Autoimmune encephalitis is most frequently associated with anti‐ NMDAR autoantibodies. Their pathogenic relevance has been suggested by passive transfer of patients' cerebrospinal fluid ( CSF ) in mice vivo. We aimed to analyze the intrathecal plasma cell repertoire, identify autoantibody‐producing clones, and characterize their antibody signatures recombinant form. Methods Patients recent onset typical were subjected flow cytometry analysis peripheral immune response...
Microglia, innate immune cells of the CNS, sense infection and damage through overlapping receptor sets. Toll‐like (TLR) 4 recognizes bacterial lipopolysaccharide (LPS) multiple injury‐associated factors. We show that its co‐receptor CD14 serves three non‐redundant functions in microglia. First, it confers an up to 100‐fold higher LPS sensitivity compared peripheral macrophages enable efficient proinflammatory cytokine induction. Second, prevents excessive responses massive challenges via...
Cortical demyelination is a widely recognized hallmark of multiple sclerosis (MS) and correlate disease progression cognitive decline. The pathomechanisms initiating driving gray matter damage are only incompletely understood. Here, we determined the infiltrating leukocyte subpopulations in 26 cortical demyelinated lesions biopsied MS patients assessed their contribution to lesion formation newly developed mouse model. We find that conformation-specific anti-myelin antibodies contribute even...
X-linked adrenoleukodystrophy (X-ALD) and metachromatic leukodystrophy (MLD) are two relatively common examples of hereditary demyelinating diseases caused by a dysfunction peroxisomal or lysosomal lipid degradation. In both conditions, accumulation nondegraded lipids leads to the destruction cerebral white matter. Because their high content, oligodendrocytes considered key pathophysiology these leukodystrophies. However, response allogeneic stem cell transplantation points relevance cells...
Abstract Remyelination is in the center of new therapies for treatment multiple sclerosis to resolve and improve disease symptoms protect axons from further damage. Although remyelination considered beneficial long term, it not known, whether this also case early lesion formation. Additionally, precise timing acute axonal damage has been assessed so far. To shed light onto interrelation between myelin sheath during de‐ remyelination, we employed cuprizone‐ focal lysolecithin‐induced...
Approximately 80% of neuromyelitis optica spectrum disorder (NMOSD) patients harbor serum anti-aquaporin-4 autoantibodies targeting astrocytes in the CNS. Crucial for NMOSD lesion initiation is disruption blood-brain barrier (BBB), which allows entrance Abs and complement into CNS a target new therapies. Astrocytes have important functions BBB maintenance; however, influence their loss role immune cell infiltration on permeability not yet been investigated. Using an experimental model...
Abstract Remyelination is a crucial regenerative process in demyelinating diseases, limiting persisting damage to the central nervous system (CNS). It restores saltatory nerve conduction and ensures trophic support of axons. In multiple sclerosis (MS) patients, remyelination has been observed both white grey matter found be more efficient cortex. Brain-enriched myelin-associated protein 1 (BCAS1) identifies oligodendrocyte lineage cells stage active myelin formation development regeneration....
Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and other neurological psychiatric conditions, but there little or no consensus as to how individual FGF family members contribute disease pathogenesis. Lesion development MS associated with increased expression of FGF1, FGF2 FGF9, all which modulate remyelination a variety experimental settings. However, FGF9 also selectively upregulated major depressive disorder (MDD), prompting us speculate it may have...
Modeling chronic cortical demyelination allows the study of long-lasting pathological changes observed in multiple sclerosis such as failure remyelination, chronically disturbed functions oligodendrocytes, neurons and astrocytes, brain atrophy cognitive impairments. We aimed at generating an animal model for studying consequences meningeal inflammation. To induce inflammation, we immunized female Lewis rats against myelin oligodendrocyte glycoprotein (MOG) injected lentiviruses continuing...
To investigate the role of fibroblast growth factor 9 (FGF9) in development grey matter lesions multiple sclerosis.