A5083924412- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Stress Responses and Cortisol
- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Single-cell and spatial transcriptomics
- Advanced Chemical Sensor Technologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Behavior and Reproduction
- Nerve injury and regeneration
- RFID technology advancements
- Evolutionary Psychology and Human Behavior
- Animal testing and alternatives
- Neurotransmitter Receptor Influence on Behavior
- Child Nutrition and Feeding Issues
- Multimedia Communication and Technology
- Hypothalamic control of reproductive hormones
- IPv6, Mobility, Handover, Networks, Security
- Primate Behavior and Ecology
- Immune cells in cancer
- Genetics, Aging, and Longevity in Model Organisms
- Receptor Mechanisms and Signaling
- Neuroscience, Education and Cognitive Function
- Gene Regulatory Network Analysis
- Diet, Metabolism, and Disease
Weizmann Institute of Science
2016-2025
Ben-Gurion University of the Negev
2014-2019
Hebrew University of Jerusalem
2019
Sexual preference for the opposite sex is a fundamental behavior underlying reproductive success, but neural mechanisms remain unclear. Here, we examined role of dopamine signaling in nucleus accumbens core (NAcc) governing chemosensory-mediated females TrpC2−/− and wild-type male mice. males, deficient VNO-mediated signaling, do not display mating or olfactory toward females. We found that, during social interaction with females, males show increased NAcc levels, observed males. Optogenetic...
Dominance hierarchy is a fundamental social phenomenon in wide range of mammalian species, critically affecting fitness and health. Here, we investigate the role pheromone signals control hierarchies individual personalities within groups wild mice. For this purpose, combine high-throughput behavioral phenotyping with computational tools freely interacting house mice, males females, an automated, semi-natural system. We show that mice form dominance both sexes but use sex-specific...
The human 1-8 interferon inducible gene family consists of at least 3 functional genes; 9-27, 1-8D and 1-8U, which are all linked on an 18-kb fragment chromosome 11 highly homologous. It has recently been shown by us others that the is overexpressed in colon carcinoma. Here, we show, sequence comparison pairs tumor/normal tissues, existence 6 different alleles, containing single-nucleotide polymorphisms with no mutations. Transformation assays revealed a possible role for as transformation...
Abstract The cerebral cortex diversified extensively during vertebrate evolution. Intriguingly, the three-layered mammalian olfactory resembles cortical cytoarchitecture of non-mammals yet evolved alongside six-layered neocortex, enabling unique comparisons for investigating neuron diversification. We performed single-nucleus multiome sequencing across mouse three- to cortices and compared types mice, reptiles salamander. identified neurons that are cortex-specific or conserved areas....
Maternal malnutrition has been associated with neurodevelopmental deficits and long-term implications on the offspring's health behavior. Here, we investigated effects of maternal low-protein diet (LPD) or obesity-inducing high-fat (HFD) dyadic social interactions, group organization autism-related behaviors in mice. We found that HFD induced an behavioral phenotype male offspring, including a robust decrease sociability, increased aggression, cognitive rigidity repetitive behaviors. LPD led...
The effect of psychoactive drugs on depression has usually been studied in cases prolonged drug addiction and/or withdrawal, without much emphasis the effects subchronic or recreational use. To address this issue, we exposed laboratory rats to regimens heroin cocaine and tested long-term (i) depressive-like behaviors, (ii) brain-derived neurotrophic factor (BDNF) levels reward-related brain regions, (iii) behavior following an additional chronic mild stress procedure. exposure was a general...
The vomeronasal organ (VNO) is specialized in detection of chemosignals, mainly pheromones, which control social communication and reproduction many mammals. These pheromones must solubilize with nasal fluids before entering the VNO, it was suggested they are delivered removed from VNO by active pumping. Yet, process to cleared unclear. In this study, we first constructed a high-resolution 3D morphological image whole adult mouse snout, using micro-CT ultra-high-resolution images. We...
Abstract Thanks to its increased sensitivity, single-shot ultrahigh field functional MRI (UHF fMRI) could lead valuable insight about subtle brain functions such as olfaction. However, UHF fMRI experiments targeting small organs next air voids, the olfactory bulb, are severely affected by inhomogeneity problems. Spatiotemporal Encoding (SPEN) is an emerging technique that provide a route for bypassing these complications. This here explored with studies on bulbs of male and female mice...
Abstract The greatest difficulty in treating cocaine addiction is the enormous rates of relapse, which occur despite immense negative consequences. Relapse risks are even greater addicts with comorbid depression, perhaps because they use drugs to alleviate depressive symptoms. Only a few preclinical studies have examined this comorbidity, mostly exploring depressive‐like effects following drug exposure. We rats from two different depression‐like models: (a) chronic‐mild‐stress (CMS), respond...
Abstract Social communication in most mammals is mediated by chemosignals, collected active sniffing and detected mainly the vomeronasal organ (VNO). In reptiles, however, chemosignals are delivered to VNO through oral cavity via nasopalatine ducts (NPDs) – two direct passageways connecting nasal cavities. While structure of NPDs highly conserved across terrestrial vertebrate, it unclear whether they retain any functional role mammalian chemosignaling. Here we assess mouse function...