A5047812313- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Amyotrophic Lateral Sclerosis Research
- Neurological disorders and treatments
- Analytical Chemistry and Chromatography
- Genetic Neurodegenerative Diseases
- Mass Spectrometry Techniques and Applications
- Glioma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Inflammatory mediators and NSAID effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Autoimmune Neurological Disorders and Treatments
- RNA regulation and disease
- Neurological and metabolic disorders
- Pancreatitis Pathology and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Trace Elements in Health
- Eosinophilic Disorders and Syndromes
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Eicosanoids and Hypertension Pharmacology
- Isotope Analysis in Ecology
Medical University of Vienna
2013-2025
Banc de Sang i Teixits
2015-2024
Jena University Hospital
2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2014-2023
Universitat de Barcelona
2011-2022
Hospital Clínic de Barcelona
1994-2022
University of Vienna
2003-2022
Erasmus MC
2021
Universidade de São Paulo
2021
Erasmus University Rotterdam
2021
Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity limited variant syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence- consensus-based revision clinical criteria PSP. Methods: searched PubMed, Cochrane, Medline, PSYCInfo databases articles English...
<b>Objective: </b> To compare the rates of conversion to Alzheimer dementia (AD) between subtypes mild cognitive impairment (MCI) in a community-based birth cohort investigated at age 75 and followed up after 30 months. <b>Methods: The Vienna Trans-Danube Aging Study every inhabitant area on left shore river Danube who was born May 1925 June 1926. With use official voting registry, 1505 subjects were contacted 697 participated. Data refer 581 nondemented individuals completed extensive...
Objective To estimate the risk for developing a defined neurodegenerative syndrome in large cohort of idiopathic REM sleep behavior disorder (IRBD) patients with long follow-up. Methods Using Kaplan-Meier method, we estimated disease-free survival rate from syndromes all consecutive IRBD diagnosed and followed-up our tertiary referal center between November 1991 July 2013. Results The comprises 174 median age at diagnosis 69 years follow-up four years. time was 33.1% five years, 75.7% ten...
It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in future. Consequently, order to reach a diagnosis of Alzheimer's disease (AD), presence hyperphosphorylated tau (HP-tau) and beta-amyloid protein brain tissue must be unequivocal. In addition, stepwise progression pathology needs assessed. This paper deals exclusively with regional assessment AD-related HP-tau pathology. The objective was provide straightforward instructions aid...
Hi-res view of human Aβ42 filaments Alzheimer’s disease is characterized by a loss memory and other cognitive functions the filamentous assembly Aβ tau in brain. The peptides into that end at residue 42 central event. Yang et al . used electron cryo–electron microscopy to determine structures from brain (see Perspective Willem Fändrich). They identified two types related S-shaped filaments, each consisting identical protofilaments. These will inform development better vitro animal models,...
Abstract The phenotypic variability of progressive supranuclear palsy (PSP) may account for its frequent misdiagnosis, in particular early stages the disease. However, large multicenter studies to define frequency and natural history PSP phenotypes are missing. In a cohort 100 autopsy‐confirmed patients we studied spectrum by retrospective chart review. Patients were derived from five brain banks with expertise neurodegenerative disorders referrals multiple academic hospitals. clinical...
ABSTRACT Lewy body (LB) diseases are characterized by alpha‐synuclein (AS) aggregates in the central nervous system (CNS). Involvement of peripheral autonomic (pANS) is increasingly recognized, although less studied. The aim this study was to systematically analyze distribution and severity AS pathology CNS pANS. Detailed postmortem histopathological brain tissues from 28 bank donors (10 with Parkinson's disease [PD], 5 dementia LB [DLB], 13 non‐LB including atypical parkinsonism dementia)....
Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed question of whether or not sequential distribution patterns can be recognized for PSP pathology. We evaluated heat maps neuronal, astroglial, oligodendroglial tau pathologies their combinations different subtypes postmortem brains. used conditional probability...
When 22 members of the BrainNet Europe (BNE) consortium assessed 31 cases with α-synuclein (αS) immunoreactive (IR) pathology applying consensus protocol described by McKeith and colleagues in 2005, inter-observer agreement was 80%, being lowest limbic category (73%). staging Braak 2003, only 65%, some as low 36%. modifications these strategies, i.e., McKeith's Leverenz from 2009, Braak's Müller 2005 were applied then increased to 78 82%, respectively. In both modifications, a reduced number...
Abstract In Parkinson’s disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. humans, neuromelanin accumulates with age, the latter being main risk factor for PD. The contribution to PD pathogenesis remains unknown because, unlike common laboratory animals lack neuromelanin. Synthesis peripheral melanins mediated by tyrosinase, an enzyme also present at low levels in brain. Here we report that overexpression human...
Genetic discoveries of Alzheimer's disease are the drivers our understanding, and together with polygenetic risk stratification can contribute towards planning feasible efficient preventive curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets by-proxy results (discovery n = 409,435 validation size 58,190). Here, we add six variants associated (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 two exonic in SHARPIN gene). Assessment...
We recently reported a novel neurological syndrome characterized by unique NREM and REM parasomnia with sleep apnea stridor, accompanied bulbar dysfunction specific association antibodies against the neuronal cell-adhesion protein IgLON5. All patients had HLA-DRB1*1001 HLA-DQB1*0501 alleles. Neuropathological findings in two revealed tauopathy restricted to neurons predominantly involving hypothalamus tegmentum of brainstem. The aim current study is describe neuropathological features...
Abstract Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include Braak stages (Braak), consensus criteria by McKeith and colleagues (McKeith), modified system Leverenz (Leverenz), Unified Staging System Beach (Beach). All these systems use semi-quantitative scoring (4- or 5-tier scales) pathology (LP; i.e. , bodies neurites) in defined cortical subcortical areas. While are widely used, some suffer from low...