Anna M. Planas
A5073488277- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Heat shock proteins research
- Atherosclerosis and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Gout, Hyperuricemia, Uric Acid
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Cerebrovascular and Carotid Artery Diseases
- Cell Adhesion Molecules Research
- Stroke Rehabilitation and Recovery
- Diabetes and associated disorders
- Advanced Neuroimaging Techniques and Applications
Institut d'Investigacions Biomèdiques de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Consejo Superior de Investigaciones Científicas
2016-2025
Centre for Biomedical Network Research on Rare Diseases
2023-2024
Instituto de Salud Carlos III
2023-2024
Universitat de Barcelona
1996-2023
University of Iowa
2023
Biomedical Research Institute
2007-2023
National Academies of Sciences, Engineering, and Medicine
2023
Clinical Trial Investigators
2022
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found about 10% patients with critical COVID-19 pneumonia, but not subjects asymptomatic infections. We detect auto-Abs 100-fold lower, more physiological, (100 pg/mL, 1/10 dilutions plasma) 13.6% 3,595 COVID-19, including 21% 374 > 80 years, and 6.5% 522 severe COVID-19. These antibodies also detected 18% the 1,124 deceased (aged 20 days-99 years; mean: 70...
Two previous pan-European consensus meetings, the 1995 and 2006 Helsingborg were convened to review scientific evidence state of current services identify priorities for research development set targets stroke care decade follow. Adhering same format, European Stroke Organisation (ESO) prepared a Action Plan (ESAP) years 2018 2030, in cooperation with Alliance Europe (SAFE). The ESAP included seven domains: primary prevention, organisation services, management acute stroke, secondary...
Abstract There is increasing evidence that astrocytes play important roles in immune regulation the brain. Astrocytes express toll‐like receptors (TLR) and build up responses to innate triggers by releasing proinflammatory molecules. We investigate signaling pathways released molecules after astrocyte TLR4 activation. Purified rodent brain cultures were treated with activator bacterial lipopolysaccharide (LPS). Tools used interfere this system include small interference RNA, inhibitory...
Numerous treatments have been reported to provide a beneficial outcome in experimental animal stroke models; however, these (with the exception of tissue plasminogen activator) failed clinical trials. To improve translation treatment efficacy from bench bedside, we performed preclinical randomized controlled multicenter trial (pRCT) test potential therapy under circumstances closer design and rigor control trial. Anti-CD49d antibodies, which inhibit migration leukocytes into brain, were...
Stroke attracts neutrophils to the injured brain tissue where they can damage integrity of blood-brain barrier and exacerbate lesion. However, mechanisms involved in neutrophil transmigration, location accumulation ischemic are not fully elucidated. Neutrophils reach perivascular spaces vessels after crossing endothelial cell layer basal lamina post-capillary venules, or migrating from leptomeninges following pial vessel extravasation and/or a suggested translocation skull bone marrow. Based...
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It important to estimate their quantitative impact on mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence these risk death increase with higher in men. Using an unvaccinated sample 1,261 deceased patients 34,159 individuals from general population, we found against IFNs strongly increased...
Abstract Hemorrhagic transformation (HT) is a complication of severe ischemic stroke after revascularization. Patients with low platelet counts do not receive reperfusion therapies due to high risk HT. The immunomodulatory drug fingolimod attenuated HT tissue plasminogen activator in thromboembolic model, but the underlying mechanism unknown. Fingolimod acts on several sphingosine-1-phosphate (S1P) receptors, prevents lymphocyte trafficking inflamed tissues, and affects brain vascular cells....
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1 , OAS2 or RNASEL five unrelated with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing generate 2′-5′-linked oligoadenylates (2-5A) activate the single-stranded RNA–degrading ribonuclease L (RNase L). Monocytic cell lines primary myeloid cells OAS1, OAS2, RNase produce excessive amounts cytokines upon dsRNA acute...
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies IFN-α2 alone (five patients) or with IFN-ω (eight from a cohort of 279 (4.7%) aged 6–73 yr influenza pneumonia. Nine four had antibodies high low concentrations, respectively, IFN-α2, six two IFN-ω. The patients’ increased A virus replication in both A549 cells reconstituted human airway epithelia. prevalence...
Cannabinoids, the active components of marijuana and their derivatives, induce tumor regression in rodents (8). However, mechanism cannabinoid antitumoral action vivo is as yet unknown. Here we show that local administration a nonpsychoactive to mice inhibits angiogenesis malignant gliomas determined by immunohistochemical analyses vascular permeability assays. In vitro experiments at least two mechanisms may be involved this action: direct inhibition endothelial cell migration survival well...
Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated cytokines. Anti-inflammatory cytokines act a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of interleukin (IL)-10 and IL-4 deteriorating ischemic stroke.Two hundred thirty-one patients with within first 24 hours from onset were included. Neurological worsening was defined when Canadian...
Journal Article A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart Get access Juan-José Fuentes, Fuentes 11Molecular Genetics Department. Cancer Research InstituteHospital Duran i Reynals, Avenida de Castelldefels Km 2 7, L'Hospitalet Llobregat, 08907 Barcelona Search for other works by this author on: Oxford Academic PubMed Google Scholar Melanie A. Pritchard, Pritchard Anna M. Planas, Planas Assumpciò Bosch,...
Matrix metalloproteinase-9 (MMP-9) activity increases in the brain during first day after focal ischemia and might be involved pathogenesis of tissue damage. We previously showed MMP-9 extracellular space parenchyma along with neutrophil recruitment ischemia. In present study, we tested whether neutrophils were a direct source enhanced ischemic brain. Neutrophil infiltration was prevented either by injecting an antibody against ICAM-1, which abrogates adhesion to endothelial vessel wall, or...