A5083516259- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Forensic Toxicology and Drug Analysis
- Pharmacological Receptor Mechanisms and Effects
- Inorganic and Organometallic Chemistry
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Chemical Reaction Mechanisms
- Synthesis and Reactions of Organic Compounds
- Organic Chemistry Cycloaddition Reactions
- Urological Disorders and Treatments
- Steroid Chemistry and Biochemistry
- Biological Activity of Diterpenoids and Biflavonoids
- Sexual Differentiation and Disorders
- GABA and Rice Research
- Gynecological conditions and treatments
- Alkaloids: synthesis and pharmacology
- Psychedelics and Drug Studies
- Synthesis and Biological Evaluation
- Molecular spectroscopy and chirality
- Chemical Synthesis and Reactions
Clemson University
2008-2024
Philips (United States)
2015
Agriculture Food and Rural Development
2000
Virginia Commonwealth University Medical Center
1996
Kennesaw State University
1996
Virginia Commonwealth University
1996
University of Hyderabad
1988
Northwestern University
1948-1983
Northwestern Memorial Hospital
1950-1973
Lurie Children's Hospital
1958-1973
Jan van Riemsdyk's work has been hailed as the acme of medical illustrator's art. His unusual contributions to development modern obstetrics and his special relationship American education set him apart from other artists. Hence, it is ironic that we know so little about him. He lived during 18th century when men were prolific letter writers chronologists, but confreres, particularly those most indebted him, tell us few things would like Although he wraith-like a person, anything ghostly....
Nonmelanoma skin cancer is one of the most common malignancies in humans. Different therapeutic strategies for treatment these tumors are currently being investigated. Given growth-inhibiting effects cannabinoids on gliomas and wide tissue distribution two subtypes cannabinoid receptors (CB1 CB2), we studied potential utility compounds anti–skin tumor therapy. Here show that CB1 CB2 receptor expressed normal mice In cell culture experiments pharmacological activation induced apoptotic death...
'Spice' is an herbal blend primarily marketed in Europe as a mild hallucinogen with prominent cannabis-like effects and legal alternative to cannabis. However, recent report identified number of synthetic additives samples 'Spice'. One these, the indole derivative JWH018, ligand for cannabinoid receptor 1 (CB(1)) inhibits cAMP production CB(1) receptor-expressing CHO cells. Other JWH018 on receptor-mediated signalling are not known, particularly neurons. Here we have evaluated pathways...
Nonmelanoma skin cancer is one of the most common malignancies in humans. Different therapeutic strategies for treatment these tumors are currently being investigated. Given growth-inhibiting effects cannabinoids on gliomas and wide tissue distribution two subtypes cannabinoid receptors (CB1 CB2), we studied potential utility compounds anti–skin tumor therapy. Here show that CB1 CB2 receptor expressed normal mice In cell culture experiments pharmacological activation induced apoptotic death...
Cannabinoids, the active components of marijuana and their derivatives, induce tumor regression in rodents (8). However, mechanism cannabinoid antitumoral action vivo is as yet unknown. Here we show that local administration a nonpsychoactive to mice inhibits angiogenesis malignant gliomas determined by immunohistochemical analyses vascular permeability assays. In vitro experiments at least two mechanisms may be involved this action: direct inhibition endothelial cell migration survival well...
A field in which Brassica napus volunteers were not controlled by several applications of glyphosate was investigated 1998. This had been planted with glufosinate-resistant and imidazolinone-resistant B. 1997 adjacent to a that grown glyphosate-resistant napus. Mature volunteer collected on 50- 100-m grid the field. Progeny from 34 sprayed at 440 g ae ha−1, survivors either glufosinate or imazethapyr 400 50 ai respectively. Where seed numbers permitted (14 volunteers), seedlings also...
Targeting cannabinoid-2 (CB(2)) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms by which CB(2) activation exerts its anti-inflammatory effects and cellular targets are elusive. Here, we investigated of CB(2)-receptor on TNF-alpha-induced signal transduction human coronary artery endothelial cells vitro endotoxin-induced vascular response vivo. TNF-alpha induced NF-kappaB RhoA upregulation adhesion molecules...
Hepatic ischemia-reperfusion (I/R) injury continues to be a fatal complication that can follow liver surgery or transplantation. We have investigated the involvement of endocannabinoid system in hepatic I/R using an vivo mouse model. Here we report triggers several-fold increases levels endocannabinoids anandamide and 2-arachidonoylglycerol, which originate from hepatocytes, Kupffer, endothelial cells. The I/R-induced increased tissue positively correlate with degree damage serum TNF-alpha,...
Early molecular modeling studies with Delta9-tetrahydrocannabinol (Delta9-THC) reported that three discrete regions which interact brain cannabinoid (CB1) receptors corresponded to the C-9 position of cyclohexene ring, phenolic hydroxyl and carbon side chain at C3 position. Although location these attachment points for aminoalkylindoles is less clear, naphthalene carbonyl group morpholinoethyl have been suggested as probable sites. In this study, a series indole- pyrrole-derived cannabinoids...
Vascular smooth muscle proliferation and migration triggered by inflammatory stimuli are involved in the development progression of atherosclerosis restenosis. Cannabinoids may modulate cell various types through cannabinoid 2 (CB2) receptors. Here, we investigated effects CB2 receptor agonists on TNF-alpha-induced proliferation, signal transduction human coronary artery cells (HCASMCs).HCASMCs were stimulated with TNF-alpha. Smooth was determined extent BrdU incorporation assayed modified...
Gathering and communicating knowledge are important aspects of the scientific endeavor. Yet presentation data in public forums such as meetings publications makes it available not only to scientists, but also others who may have different ideas about how use research findings. A recent example this type hijacking is introduction synthetic cannabinoids that sprayed on herbal products subsequently smoked for their marijuana-like intoxicating properties. Originally developed legitimate purpose...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTSynthesis and Pharmacology of a Very Potent Cannabinoid Lacking Phenolic Hydroxyl with High Affinity for the CB2 ReceptorJohn W. Huffman, Shu Yu, Vincent Showalter, Mary E. Abood, Jenny L. Wiley, David R. Compton, Billy Martin, Daniel Bramblett, Patricia H. ReggioView Author Information Department Chemistry, Clemson University, Clemson, South Carolina 29634-1905, Toxicology, Medical College Virginia, Virginia Commonwealth Richmond, 23298, Kennesaw...
In the course of efforts to develop new nonsteroidal antiinflammatory agents, it was discovered that 1-aminoalkyl-3-aroylindoles have affinity for cannabinoid brain (CB1 ) receptor. This led synthesis well over 100 cannabimimetic aminoalkylindoles by group at Sterling Winthrop, and development structure-activity relationships (SAR) these compounds. These SAR require a heterocyclic aminoethyl attached indole nitrogen, 1-naphthoyl C-3 significant receptor affinity. Other workers subsequently...