A5076734364- Attention Deficit Hyperactivity Disorder
- Reading and Literacy Development
- Hemispheric Asymmetry in Neuroscience
- Cognitive and developmental aspects of mathematical skills
- Children's Physical and Motor Development
- Child and Adolescent Psychosocial and Emotional Development
- Neurobiology of Language and Bilingualism
- Neural and Behavioral Psychology Studies
- Language Development and Disorders
- Educational and Psychological Assessments
- Neuroscience, Education and Cognitive Function
- Cyclopropane Reaction Mechanisms
- Cognitive Abilities and Testing
- Cyclization and Aryne Chemistry
- Infant Development and Preterm Care
- Synthesis and Catalytic Reactions
- Autism Spectrum Disorder Research
- Catalytic Alkyne Reactions
- X-ray Diffraction in Crystallography
- Behavioral and Psychological Studies
- Spatial Neglect and Hemispheric Dysfunction
- Crystallization and Solubility Studies
- Functional Brain Connectivity Studies
- Developmental and Educational Neuropsychology
- Asymmetric Synthesis and Catalysis
Winthrop University
2024
Charles River Laboratories (United Kingdom)
2018-2020
College of Charleston
2012-2013
Arizona State University
2008-2009
Purdue University West Lafayette
2003-2007
University of Georgia
1997-2006
University of Bristol
2001-2006
Northeastern University
1999-2005
Clemson University
2001-2004
University of Dundee
1999-2002
Optimal diagnostic thresholds were determined for DSM-IV attention deficit hyperactivity disorder, and the psychometric properties compared to alternative definitions.Structured interviews of multiple informants 380 clinic-referred youths aged 4-17 years conducted. In addition, standardized clinicians' validation diagnoses disorder obtained assess agreement with clinical judgment. Measures impairment accuracy identifying youth an impairing condition.Three subtypes (predominantly inattentive,...
• This study examined the specificity of deviations in patterns normal brain asymmetry on magnetic resonance imaging scans 10 dyslexic, attention deficit disorder/hyperactivity (ADD/H), and age- sex-matched control children. Reliabilities region interest measurements for left right anterior posterior width area, length bilateral insular region, planum temporale were excellent. Both dyslexic ADD/H children had significantly smaller anterior-width than did subjects. The dyslexics also a...
There has long been speculation as to the development of behaviors attributed frontal lobe functioning in children. Controversy exists when become fully developed. This study examined performance normal male and female children at four age levels between 6 12 years age. Performance on verbal nonverbal proactive retroactive inhibition, conflict, two perseve‐ration tasks was assessed. The results suggested that children, associated with is a multistage process. greatest period appeared occur...
The neurologic basis of attention deficit-hyperactivity disorder (ADHD) is poorly understood. Based on previous studies that have implicated metabolic deficiencies in the caudate-striatal region ADHD, we employed magnetic resonance imaging to investigate patterns morphology head caudate nucleus normal and ADHD children. In children, 72.7% evidenced a left-larger-than-right (L > R) pattern asymmetry, whereas 63.6% children had reverse < asymmetry nucleus. This reversal was due...
Although behavioral evidence provides support for the notion that attention deficit-hyperactivity disorder (ADHD) is related to central nervous system dysfunction, there little direct reveal which neurometabolic systems or brain structures are involved. Recent magnetic resonance imaging (MRI) studies suggest that, compared nondisabled controls, ADHD children may have a smaller right frontal region. Morphometric analysis of MRI scans was used in this exploratory study determine whether...
Imines and alkenes can be converted into the corresponding aziridines cyclopropanes (see scheme, PTC=phase-transfer catalyst, Ts=toluene-4-sulfonyl) in good yield with moderate to high d.r. ee values using tosylhydrazone salts catalytic quantities of chiral sulfide (5–20 mol %) metal catalyst (1 %). The process is particularly suited synthesis conformationally locked cyclopropyl amino acids, which now prepared only three steps from commercially available material 100 % ee. Supporting...
To develop quantitative methods for identifying cerebral anomalies on magnetic resonance images of subjects with language disorders and other learning disabilities.Partially blinded comparison dyslexia, unaffected relatives, a control group balanced age socioeconomic status. Criterion standard: clinical diagnosis dyslexia by physician or disabilities specialist the basis assessment family history.Hospital pediatric neurology clinic private reading clinic.individuals (seven male two female,...
There is evolving evidence that developmental dyslexia associated with anomalous cerebral morphology in the bilateral frontal and left temporoparietal regions. This study examined of corpus callosum, as possible deviations other important structures are poorly understood this behaviorally diagnosed syndrome.Magnetic resonance imaging scans were obtained from children matched control children. Morphometric measurements to determine if regional differences existed callosum between these two...
A practical, general, and convergent route to epoxides with control of the relative absolute stereochemistry has been achieved by generating reactive intermediate (the diazo compound) in situ from tosylhydrazone salts (see scheme, PTC=phase-transfer catalyst, Ts=toluene-4-sulfonyl). High yields (58–82 %), high d.r. (88:12–98:2), ee values (87–94 %) have obtained using a new class stable chiral sulfides at low catalyst loading (5 mol [Rh2(OAc)4] (0.5 %). Supporting information for this...
The purpose of the field trials for oppositional defiant disorder and conduct was to select valid diagnostic thresholds these disorders compare psychometric properties DSM-IV criteria with previous DSM formulations.Structured interviews, standardized clinician's validation diagnoses, multiple measures impairment were obtained 440 clinic-referred children adolescents aged 4-17 years.A threshold four symptoms optimized identification impaired children, improved agreement somewhat diagnosis,...
Abstract Reviewed behavioral and neuropsychological studies addressing attention-deficit disorder with (ADD/H) and: without (ADD/WO) hyperactivity. Review of the suggests that children ADD/H have more behavior problems, are less popular, self-destructive, likely to a codiagnosis conduct disorder. Children ADD/WO seem socially withdrawn, slower cognitive tempo, self-conscious, higher incidence developmental learning disorders. Neuropsychological suggest or may differ electrophysiologically...
Abstract Controversy exists as to when behaviors associated with frontal lobe functioning become fully developed in normal children. This investigation examined the development children of nonverbal ability regulate and inhibit motor action perform on tasks involving temporal ordering. Normal Black White boys girls ranging age from 5 12 years were go‐no go decisions, auditory‐sequential visual‐simultaneous conflict tasks, a task Significant effects found all tasks. Six‐year‐olds clearly...
This study examined the issue as to whether or not children carefully diagnosed having either attention deficit disorder with hyperactivity (ADDH) without (ADDnoH) could be distinguished on selected cognitive, academic, rapid naming, and behavioral measures. Employing a previously validated multimodal, multi-informant diagnostic process that results in reliable clinical diagnoses, 10 ADDH ADDnoH were examined. While no significant differences cognitive ability noted between groups,...