A5032990625- Molecular Junctions and Nanostructures
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Nanowire Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
- Quantum Dots Synthesis And Properties
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Semiconductor materials and devices
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Click Chemistry and Applications
- Virus-based gene therapy research
- Advanced Biosensing Techniques and Applications
- Graphene research and applications
- Supramolecular Chemistry and Complexes
- Single-cell and spatial transcriptomics
- Silicon Nanostructures and Photoluminescence
- Advanced biosensing and bioanalysis techniques
- Fullerene Chemistry and Applications
- Long-Term Effects of COVID-19
- Force Microscopy Techniques and Applications
- Carbon Nanotubes in Composites
- vaccines and immunoinformatics approaches
University of Washington
2020-2025
Institute for Systems Biology
2004-2025
Parker Institute for Cancer Immunotherapy
2020-2025
Systems Biology Institute
2025
California Institute of Technology
2014-2024
University of California, Los Angeles
2012-2024
Sandia National Laboratories California
2024
InSysBio (Russia)
2019-2023
Seattle University
2019-2023
UCLA Jonsson Comprehensive Cancer Center
2019-2023
Logic gates were fabricated from an array of configurable switches, each consisting a monolayer redox-active rotaxanes sandwiched between metal electrodes. The switches read by monitoring current flow at reducing voltages. In the "closed" state, was dominated resonant tunneling through electronic states molecules. irreversibly opened applying oxidizing voltage across device. Several devices configured together to produce AND and OR logic gates. high low levels those separated factors 15 30,...
A solid state, electronically addressable, bistable [2]catenane-based molecular switching device was fabricated from a single monolayer of the [2]catenane, anchored with phospholipid counterions, and sandwiched between an n-type polycrystalline silicon bottom electrode metallic top electrode. The exhibits hysteretic (bistable) current/voltage characteristics. switch is opened at +2 volts, closed -2 read approximately 0.1 volt may be recycled many times under ambient conditions....
Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; we have been pursuing possibility these differences may be reflected by multiparameter measurements of blood. Such concepts transforming current diagnostic therapeutic medicine and, together with new technologies, will enable a predictive preventive lead personalized medicine.
Intimate electrical contact occurs between a substituted poly(metaphenylenevinylene) (PmPV) and bundles of single-walled nanotubes (SWNT) as evidenced by atomic force microscopy, optical, electronic measurements carried out on single, isolated SWNT/PmPV structures (see picture). PmPV may provide useful route toward "functionalizing" the SWNT without destroying their character. Supporting information for this article is available WWW under...
We report on the synthesis and characterization of 25−70 Å diameter amine-capped gold nanocrystals. In particular, we show how these particles can be prepared by a simple procedure confirm particle composition (including identity amine surface passivant) through several materials techniques that include infrared spectroscopy, nuclear magnetic resonance ultraviolet−visible mass X-ray photoelectron transmission electron microscopy, diffraction analysis, differential scanning calorimetry,...
Teramac is a massively parallel experimental computer built at Hewlett-Packard Laboratories to investigate wide range of different computational architectures. This machine contains about 220,000 hardware defects, any one which could prove fatal conventional computer, and yet it operated 100 times faster than high-end single-processor workstation for some its configurations. The defect-tolerant architecture Teramac, incorporates high communication bandwith that enables easily route around...
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation 309 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data patient-reported symptoms. resolved four PASC-anticipating at the time diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, specific...
We describe a general method for producing ultrahigh-density arrays of aligned metal and semiconductor nanowires nanowire circuits. The technique is based on translating thin film growth thickness control into planar wire arrays. Nanowires were fabricated with diameters pitches (center-to-center distances) as small 8 nanometers 16 nanometers, respectively. have high aspect ratios (up to 10(6)), the process can be carried out multiple times produce simple circuits crossed junction density in...
The linear and nonlinear (χ (2) ) optical responses of Langmuir monolayers organically functionalized silver quantum dots were measured as a continuous function interparticle separation under near-ambient conditions. As the distance between metal surfaces was decreased from 12 to ∼5 angstroms, both classical effects observed in signals. When less than 5 second-harmonic generation (SHG) response exhibited sharp discontinuity, reflectance absorbance began resemble those thin metallic film,...
Improvements in our understanding of how molecules transport charge, and they interface to the macroscopic world, are fueling new devices applications.
Ordered arrays, or superlattices, of metallic, insulating, semiconducting quantum dots, represent an exciting new class materials. These superlattices are often referred to as artificial solids, in which the nanocrystals take place atoms traditional and packing arrangement determines unit cell parameters superstructure. In this review, we discuss various approaches toward assembling nanocrystal their physical properties.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic Control of Gold Nanocrystal Size: Experiment and TheoryDaniel V. Leff, Pamela C. Ohara, James R. Heath, William M. GelbartCite this: J. Phys. Chem. 1995, 99, 18, 7036–7041Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 1995https://pubs.acs.org/doi/10.1021/j100018a041https://doi.org/10.1021/j100018a041research-articleACS PublicationsRequest reuse permissionsArticle...
Common-or-garden starch can render single-walled carbon nanotubes (SWNTs) readily soluble in water. The secret is to preorganize the linear amylose component into a helix with iodine prior bringing SWNTs on scene. displace molecules "pea-shooting" type of mechanism (see scheme). After some physical cajoling aqueous solution containing starch–SWNT complex, fine "bucky paper" formed. Spitting solution, followed by sitting around for few hours, also enables equally be harvested.
Playing Hide and Seek Targeted cancer therapies have shown promising results in patients, but few of these drugs provide long-term benefits because tumor cells rapidly develop drug resistance. Nathanson et al. (p. 72 , published online 5 December) show that glioblastoma can become resistant to erlotinib, an epidermal growth factor receptor (EGFR)–targeted drug, by eliminating extrachromosomal copies the mutant EGFR gene. After a period withdrawal, gene reappears on DNA resensitized. The...
Addressing an array of bistable [2]rotaxanes through a two-dimensional crossbar arrangement provides the device element current-driven molecular electronic circuit. The development [2]rotaxane switches iterative, evolutionary process is described. reported here allows both memory and logic functions to use same elements.
We present an integrated analysis of the clinical measurements, immune cells, and plasma multi-omics 139 COVID-19 patients representing all levels disease severity, from serial blood draws collected during first week infection following diagnosis. identify a major shift between mild moderate disease, at which point elevated inflammatory signaling is accompanied by loss specific classes metabolites metabolic processes. Within this stressed environment multiple unusual cell phenotypes emerge...
The phase behavior of organically passivated 20−75 Å diameter Ag and Au nanocrystals is investigated by examining surface−area isotherms Langmuir monolayers transmission electron micrographs Langmuir−Blodgett (LB) films. effects temperature, organic passivant chain length, nanocrystal size composition are studied. Three distinct types observed may be classified in terms the extra (conical) volume (Ve) available to alkyl capping group as it extends from a nearly spherical metal core. For Ve >...
Quantum-confined InP nanocrystals from 20 to 50 Å in diameter have been synthesized via the reaction of InCl3 and P(Si(CH3)3)3 trioctylphosphine oxide (TOPO) at elevated temperatures. The are highly crystalline, monodisperse, soluble various organic solvents. Improved size distributions obtained by size-selectively reprecipitating nanocrystals. UV/vis absorption spectra particles show characteristic blue shift band gap up 1 eV due quantum confinement, a moderately well-resolved first...
Microreactor technology has shown potential for optimizing synthetic efficiency, particularly in preparing sensitive compounds. We achieved the synthesis of an [(18)F]fluoride-radiolabeled molecular imaging probe, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), integrated microfluidic device. Five sequential processes-[18F]fluoride concentration, water evaporation, radiofluorination, solvent exchange, and hydrolytic deprotection-proceeded with high radio-chemical yield purity shorter time...