A5101661551- Ultrasound in Clinical Applications
- Radiology practices and education
- Radiation Dose and Imaging
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Innovations in Medical Education
- Venous Thromboembolism Diagnosis and Management
- Trauma and Emergency Care Studies
- Trauma Management and Diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Reproductive tract infections research
- Appendicitis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Diversity and Career in Medicine
- COVID-19 diagnosis using AI
- Gut microbiota and health
- Urinary Tract Infections Management
- COVID-19 and healthcare impacts
- Abdominal Trauma and Injuries
- Neutropenia and Cancer Infections
- Autopsy Techniques and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Urological Disorders and Treatments
- Simulation-Based Education in Healthcare
University of Toronto
2022-2025
Yale University
2016-2025
Impact
2023
Yale New Haven Hospital
2015-2023
McMaster University
2023
Toronto East General Hospital
2023
Institute for Systems Biology
2020-2022
University of Michigan–Ann Arbor
2015-2022
Trinity Health
2022
Vancouver General Hospital
2022
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation 309 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data patient-reported symptoms. resolved four PASC-anticipating at the time diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, specific...
We present an integrated analysis of the clinical measurements, immune cells, and plasma multi-omics 139 COVID-19 patients representing all levels disease severity, from serial blood draws collected during first week infection following diagnosis. identify a major shift between mild moderate disease, at which point elevated inflammatory signaling is accompanied by loss specific classes metabolites metabolic processes. Within this stressed environment multiple unusual cell phenotypes emerge...
Shortness of breath is a major reason that patients present to the emergency department (ED) and point-of-care ultrasound (POCUS) has been shown aid in diagnosis, particularly through evaluation for artifacts known as B-lines. B-line identification quantification can be challenging skill novice users, experienced users could benefit from more objective measure quantification. We sought develop test deep learning (DL) algorithm quantify assessment B-lines lung ultrasound. utilized clips (n =...
Abstract Objectives The purpose of this study is to provide expert consensus recommendations establish a global ultrasound curriculum for undergraduate medical students. Methods 64 multi-disciplinary experts from 16 countries, 50 consultants, and 21 students residents contributed these recommendations. A modified Delphi method was used that included systematic literature search, evaluation the quality by GRADE system, RAND appropriateness panel judgment decisions. process four in-person...
Background. Bacterial vaginosis (BV) causes genital inflammation and increases HIV risk, whereas a vaginal microbiota dominated by Lactobacillus species is associated with immune quiescence relative protection. BV treatment reduces inflammation, but it unclear whether this reduction driven decrease in BV-associated bacteria or an increase species.
Genital inflammation increases HIV susceptibility and is associated with the density of pro-inflammatory anaerobes in vagina coronal sulcus. The penile urethra a critical site acquisition, although correlates urethral acquisition are largely unknown. While Streptococcus mitis consistent component flora, presence Gardnerella vaginalis has been linked prior penile-vaginal sex inflammation. Here, we use flow cytometry-based bacterial assay to quantify IgA IgG that bind G. S. cross-sectional...
Abstract Emergency physician ( EP )‐performed focused cardiac ultrasound FOCUS ) has been increasingly recognized as a crucial tool to help clinicians diagnose and treat potentially life‐threatening conditions. The existing literature demonstrates variety of applications protocols; however, is not taught, practiced, or interpreted consistently between institutions. Drawing on over 12 years experience in large‐volume, high‐acuity academic emergency department, we have developed protocol for...
We have recently tested an automated machine-learning algorithm that quantifies left ventricular (LV) ejection fraction (EF) from guidelines-recommended apical views. However, in the point-of-care (POC) setting, 2-chamber views are often difficult to obtain, limiting usefulness of this approach. Since most POC physicians rely on visual assessment 4-chamber and parasternal long-axis views, our was adapted use either one these 3 or any combination. This study aimed (1) test accuracy estimates;...
Abstract Competency in clinical ultrasound is essential to ensuring safe patient care. includes identifying when perform a ultrasound, performing the technical skills required for image acquisition, accurately interpreting images, and incorporating sonographic findings into practice. In this concept paper, we discuss advantages limitations of existing tools measure competency. We propose strategies future directions assessing competency ultrasound.
ABSTRACT Vaginal colonization by fungi may elicit genital inflammation and enhance the risk of adverse reproductive health outcomes, such as HIV acquisition. Cross-sectional studies have linked with an absence bacterial vaginosis (BV), but it is unclear whether shifts in vaginal bacteria alter abundance fungi. swabs collected following topical metronidazole treatment for BV during phase 2b, placebo-controlled trial LACTIN-V, a Lactobacillus crispatus -based live biotherapeutic, were assayed...
Abstract Point-of-care ultrasound (POCUS) has emerged as a standard of care across variety healthcare settings due to its ability provide critical clinical information and well procedural guidance clinicians directly at the bedside. Implementation enterprise imaging (EI) strategies is needed such that POCUS images can be appropriately captured, indexed, managed, stored, distributed, viewed, analyzed. Because unique workflow educational requirements, reliance on traditional order-based...
Lung ultrasound (LUS) aids in the diagnosis of patients with dyspnea, including those cardiogenic pulmonary edema, but requires technical proficiency for image acquisition. Previous research has demonstrated effectiveness artificial intelligence (AI) guiding novice users to acquire high-quality cardiac images, suggesting its potential broader use LUS. To evaluate ability AI guide acquisition diagnostic-quality LUS images by trained health care professionals (THCPs). In this multicenter...
Abstract Background The composition of the vaginal microbiota is closely linked to adverse sexual and reproductive health outcomes, due in part effects on genital immunology. Compositional approaches such as metagenomic sequencing provide a snapshot all bacteria sample have become standard for characterizing microbiota, but only microbial relative abundances. We hypothesized that addition absolute abundance data would more complete picture host-microbe interactions female tract. Results...
RATIONALE: Critical care ultrasonography (CCUS) is rapidly evolving with new evidence being published since the prior 2016 guideline. OBJECTIVES: To identify and assess best regarding clinical outcomes associated five CCUS applications in adult patients publication of previous guidelines. PANEL DESIGN: An interprofessional, multidisciplinary, diverse expert panel 36 individuals including two patient/family representatives was assembled via an intentional approach. Conflict-of-interest...
Abstract Background Focused cardiac ultrasound ( FOCUS ) is insensitive for pulmonary embolism PE ). Theoretically, when a clot large enough to cause vital sign abnormalities, it more likely show signs of right ventricular dysfunction on , although this has not been well quantified. A rapid bedside test that could quickly and reliably exclude in patients with abnormal be high utility emergency department ED patients. We hypothesized tachycardia or hypotension, the sensitivity would increase...
Abstract In 2012 the Accreditation Council for Graduate Medical Education and American Board of Emergency Medicine released emergency medicine milestones. The Patient Care 12 ( PC 12) subcompetency delineates staged progressive accomplishment in ultrasound. While valuable as an initial framework ultrasound resident education, there are limitations to 12. This consensus paper provides a revised description criteria define subcompetency. A multiorganizational task force was formed between...