A5071224434- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Animal Virus Infections Studies
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
Bandung Institute of Technology
2023-2024
Medical University of Białystok
2021-2024
Institute for Systems Biology
2022
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation 309 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data patient-reported symptoms. resolved four PASC-anticipating at the time diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, specific...
Obesity rates among children are growing rapidly worldwide, placing massive pressure on healthcare systems. Untargeted metabolomics can expand our understanding of the pathogenesis obesity and elucidate mechanisms related to its symptoms. However, metabolic signatures in have not been thoroughly investigated. Herein, we explored metabolites associated with development childhood. metabolomic profiling was performed fasting serum samples from 27 obese Caucasian adolescents 15 sex- age-matched...
This study aimed to evaluate microRNAs (miRNAs) as predictive biomarkers for type 2 diabetes (T2D) remission 12 months after sleeve gastrectomy (SG).A total of 179 serum miRNAs were profiled, and 26 clinical variables collected from 46 patients. Two patients later excluded because hemolysis, six with unclear status set aside the prediction models. The remaining 38 included model building. Variable selection was done using different approaches, including Least Absolute Shrinkage Selection...
Hepatitis B remains a global problem with no effective treatment. Here, mucosal vaccine candidate was developed HBsAg and HBcAg, to provide both prophylactic therapeutic protection against hepatitis B. The antigens were presented using the P particle of human norovirus (HuNov). As result, chimeric HBV - HuNoV can act as dual for HuNoV. expressed purified from Escherichia coli BL21 (DE3) cells. HBV-HuNoV particles successfully isolated, sizes approximately 25.64 nm. Then, evaluated safety...
Hepatitis B virus (HBV) remains an important healthcare challenge, leading to liver diseases like cirrhosis and cancer. In response, we created a prophylactic therapeutic HBV vaccine by integrating HBcAg HBsAg from genotype into Norovirus (NoV) GII.2 P domain (PdomGII.2-HBV) for enhanced intranasal delivery. This also aimed simultaneously prevent NoV infection, which causes gastroenteritis. Since the selected epitopes have undergone extensive research are tailored Indonesian population, this...
A novel pathophysiology-based method to subphenotype individuals at elevated risk for type 2 diabetes has recently identified 6 subgroups, of which constitute obese, high-risk subpopulations with different glycemic, renal, cardiovascular and all-cause mortality profiles. The aim our study was evaluate differences in response weight-loss surgery between these clusters, termed clusters 5 & by Wagner et al. We performed this clustering on the Bialystok Bariatric Surgery Study Cohort...