A5056944859- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- COVID-19 Clinical Research Studies
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Cholesterol and Lipid Metabolism
- Lipid metabolism and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Synthesis and biological activity
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Thyroid Disorders and Treatments
- Muscle Physiology and Disorders
- thermodynamics and calorimetric analyses
- Computational Drug Discovery Methods
- Ultrasound in Clinical Applications
- Flavonoids in Medical Research
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- Free Radicals and Antioxidants
- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
Medical University of Białystok
2022-2024
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2016-2023
Polish Academy of Sciences
2016-2023
University of Nebraska–Lincoln
2023
Obesity rates among children are growing rapidly worldwide, placing massive pressure on healthcare systems. Untargeted metabolomics can expand our understanding of the pathogenesis obesity and elucidate mechanisms related to its symptoms. However, metabolic signatures in have not been thoroughly investigated. Herein, we explored metabolites associated with development childhood. metabolomic profiling was performed fasting serum samples from 27 obese Caucasian adolescents 15 sex- age-matched...
Apigenin, a naturally derived flavonoid, is increasingly being acknowledged for its potential therapeutic applications, especially in oncology. This research explores apigenin’s capacity to modulate cancer cell viability, emphasizing roles beyond minimal antioxidant activity attributed basic molecular structure devoid of hydroxyl groups. We investigated effects on two breast lines, estrogen-dependent MCF-7 and non-estrogen-dependent MDA-MB-231 cells. Our findings reveal that apigenin exerts...
Stearoyl-CoA desaturase 1 (SCD1), an enzyme that is involved in the biosynthesis of monounsaturated fatty acids, induces reprogramming cardiomyocyte metabolism. Thyroid hormones (THs) activate both lipolysis and lipogenesis. Many genes are lipid metabolism, including Scd1, regulated by THs. The present study used SCD1 knockout (SCD1−/−) mice to test hypothesis THs important factors mediate anti-steatotic effect downregulation heart. deficiency decreased plasma levels thyroid-stimulating...
The role of canonical Wnt signaling in metabolic regulation and development physiological cardiac hypertrophy remains largely unknown. To explore the function β-catenin metabolism development, we used mice heterozygous for cardiac-specific knockout that were subjected to a swimming training model. β-Catenin haploinsufficient endurance displayed decreased transcriptional activity, attenuated cardiomyocytes hypertrophic growth, enhanced activation AMP-activated protein kinase (AMPK),...
Stearoyl-CoA desaturase 1 (SCD1) is an enzyme that involved in the regulation of lipolysis heart. SCD1 also affects epigenetic mechanisms, such as DNA and histone modifications, various tissues. Both modifications changes lipid metabolism are heart's response to hypoxia. The present study tested hypothesis interact control cardiomyocytes under normoxic hypoxic conditions. We found inhibition activity loss expression reduced global methylation levels, methyltransferase (DNMT) activity, DNMT1...
A complex of the natural flavonoid kaempferol with zinc (Kam-Zn) was synthesized, and its physicochemical properties were investigated using spectroscopic methods such as Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible (UV-Vis) theoretical chemistry. Biological studies conducted to evaluate cytotoxic antiproliferative effects these complexes on MCF-7 breast cancer cells. Treatment Kam 100 µM (84.86 ± 7.79%; 64.37 8.24%) Kam-Zn (91.87 3.80%; 87.04 13.0%) showed no...
Even though fatty acids (FAs) are the main source of energy for cardiomyocytes, in pathological conditions heart shifts its metabolism toward increased glucose reliance, which leads to excess accumulation FAs form triglycerides (TGs) and cardiac dysfunction. Therefore, we have investigated role liver X receptor (LXR), a nuclear that regulates lipid homeostasis, muscle during progressive obesity. As model used 8-week-old, male, hyperphagic MC4R knockout mice (MC4RKO), wildtype C57BL/6J (WT)...
While nonalcoholic fatty liver disease (NAFLD) affects approx. 30% of the US population, there is currently no approved pharmaceutical treatment to inhibit progression NAFLD its more severe stage steatohepatitis (NASH). The X receptors (LXRs) are key regulators cholesterol and acid homeostasis in liver. However, effects LXR activation on metabolism NASH pathogenesis not well understood. We hypothesize that might reduce by augmenting lipid composition hepatocytes. To test this hypothesis,...