A5103158963- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- COVID-19 and Mental Health
- Misinformation and Its Impacts
- Neuroendocrine regulation and behavior
- Sleep and related disorders
- Neural and Behavioral Psychology Studies
- Health disparities and outcomes
- Psychological Well-being and Life Satisfaction
- Dementia and Cognitive Impairment Research
- Cognitive Functions and Memory
- Tryptophan and brain disorders
- Infant Health and Development
- Sleep and Wakefulness Research
- Sentiment Analysis and Opinion Mining
- Media Influence and Health
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Attachment and Relationship Dynamics
- Psychological and Temporal Perspectives Research
- Glaucoma and retinal disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
University of Surrey
2017-2025
Institute for Systems Biology
2022
InSysBio (Russia)
2022
University of Oxford
2005-2021
Oxford Health NHS Foundation Trust
2021
University of Sussex
2012-2020
University of Michigan–Ann Arbor
2020
Sobell House
2010-2012
University College London
2010-2012
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation 309 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data patient-reported symptoms. resolved four PASC-anticipating at the time diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, specific...
Background Studies have suggested that patients with schizophrenia are impaired at recognizing emotions. Recently, it has been shown the neuropeptide oxytocin can beneficial effects on social behaviors. Method To examine emotion recognition deficits in and see whether could improve these deficits, we carried out two experiments. In first experiment recruited 30 29 age- IQ-matched control subjects, gave them an task. Following this, a second which 21 for double-blind, placebo-controlled...
Concerns have been raised regarding middle-aged and older adults’ mental health during the coronavirus outbreak. The aim of current study was to characterise associations between internet use (frequency purpose), depression symptoms Quality Life (QoL) pandemic, in individuals aged 55–75. Data (N = 3491) were drawn from English longitudinal ageing (ELSA) cohort collected June/July 2020 (while social distancing measures place). Associations with frequency tested using analysis covariance...
The apolipoprotein E (APOE) e4 allele is strongly associated with increased risk of cognitive impairments in older adulthood. There also a possible link to enhanced performance younger adults, and the APOE may constitute an example antagonistic pleiotropy. aim this work was investigate neural (functional) effects during mid-age (45-55 years), where transition toward deficit might be expected. carriers (e4+) were compared non-e4 (e4-) on tasks sustained covert attention prospective memory,...
Abstract Cognitive impairments are a core and persistent characteristic of schizophrenia with implications for daily functioning. These show only limited response to antipsychotic treatment their neural basis is not well characterised. Previous studies point relationships between cortical thickness cognitive performance in fronto-temporal brain regions patients (SZH). There also evidence that these might be independent symptom severity, suggesting dissociable disease processes. We set out...
The presence of the e4 allele apolipoprotein E ( APOE ) gene is best‐known genetic risk factor for Alzheimer's disease . In this study, we investigated link between functional and behavioural differences regional brain volume cortical thickness in those who carry (e4+) only e3 (e3/e3). We studied these genotype populations two age groups: a young group (average age, 21 years) mid‐age 50 years). High‐resolution T 1 ‐weighted MRI scans were analysed with Freesurfer to measure white matter...
Background The COVID-19 pandemic and resultant social restrictions have had widespread psychological ramifications, including a rise in depression prevalence. However, longitudinal studies on sociodemographic risk factors are lacking. Aims To quantify changes symptoms during the compared with pre-pandemic baseline, middle-aged older adults, identify contributing to this. Method A total of 5331 participants aged ≥50 years were drawn from English Longitudinal Study Ageing. Self-reported...
Loneliness among older adults is a major societal problem with consequences for health and wellbeing; this has been exacerbated by the coronavirus pandemic. The present study investigated associations between internet use, including frequency type of loneliness in large UK sample middle-aged adults, aged 55–75 (n = 3500) from English Longitudinal Study Ageing (ELSA) cohort study. Our findings indicated clear relationship use subjective loneliness. Those who used more than once day reported...
ABSTRACT Neuroimaging research in the field of schizophrenia and other psychotic disorders has sought to investigate neuroanatomical markers, relative healthy control groups. In recent decades, a large number structural magnetic resonance imaging (MRI) studies have been funded undertaken, but their small sample sizes heterogeneous methods led inconsistencies across findings. To tackle this, efforts made combine datasets sites. While notable multicentre initiatives resulting meta‐...
Background Chronotype influences risk of depression, with evening-types at higher risk, although the reasons for this are uncertain. Potential mediating factors include mindfulness, sleep quality, rumination, and alcohol consumption, but research is lacking. Methods We explored role these in association between chronotype depressive symptoms amongst young adults, using cross-sectional data collected from a university student sample ( N = 546). Results Evening-types had significantly levels...
Fear is coupled to states of physiological arousal. We tested how learning and memory threat, specifically conditioned fear, influenced by interoceptive signals. Forty healthy individuals were exposed two threat (conditioned stimuli [CS+], paired with electrocutaneous shocks) safety (CS-) stimuli, time-locked either cardiac ventricular systole (when arterial baroreceptors signal cardiovascular arousal brainstem), or diastole these afferent signals are quiescent). Threat was indexed...
Media has played an important role in public information on COVID-19. But distressing news, e.g., COVID-19 death tolls, may trigger negative emotions public, discouraging them from following the which, turn, can limit effectiveness of media. To understand people's emotional response to we have investigated prevalence basic human around 19 million user responses 1.7 news posts Twitter (English-speaking) media across 12 countries January 2020 April 2021. We used Latent Dirichlet Allocation...
The emotional impact of the COVID-19 pandemic and ensuing social restrictions has been profound, with widespread negative effects on mental health. We made use natural language processing large-scale Twitter data to explore this in depth, identifying emotions news content user reactions it, how these evolved over course pandemic. focused major UK channels, constructing a dataset COVID-related tweets (tweets from organisations) comments response these, covering Jan 2020 April 2021. Natural...
Metacognition is impaired in schizophrenia and an important predictor of functional outcome, but the underlying neuropathology not clear. Studies have implicated frontal regions there also some evidence that hippocampus might play a pivotal role, findings are inconsistent. We set out to more comprehensively investigate neural underpinnings insight first-episode psychosis (FEP) using 2 metacognitive measures (the Beck Cognitive Insight Scale [BCIS]) perceptual accuracy task alongside...