A5002247247- Circadian rhythm and melatonin
- COVID-19 Clinical Research Studies
- Obstructive Sleep Apnea Research
- Wikis in Education and Collaboration
- Neuroscience of respiration and sleep
- Web and Library Services
- Pancreatic function and diabetes
- RNA modifications and cancer
- Light effects on plants
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- COVID-19 and Mental Health
- Biomedical and Engineering Education
- Genetics, Aging, and Longevity in Model Organisms
- Non-Invasive Vital Sign Monitoring
- Dietary Effects on Health
- Natural Language Processing Techniques
- Fermentation and Sensory Analysis
- Central Venous Catheters and Hemodialysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diabetes and associated disorders
- Sleep and related disorders
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Artificial Intelligence in Healthcare and Education
University of Lausanne
2017-2024
University Hospital of Geneva
2024
University of Geneva
2024
Technion – Israel Institute of Technology
2020-2023
Weizmann Institute of Science
2019-2022
Pennsylvania Academy of Science
2019
American Institute of Ultrasound in Medicine
2019
Northwell Health
2019
American Academy of Arts and Sciences
2019
École Polytechnique Fédérale de Lausanne
2016-2018
There is strong evidence for an involvement of different classes non-coding RNAs, including microRNAs and long in the regulation β-cell activities diabetes development. Circular RNAs were recently discovered to constitute a substantial fraction mammalian transcriptome but contribution these physiological disease processes remains largely unknown. The goal this study was identify circular expressed pancreatic islets elucidate their possible role control β-cells functions. We used microarray...
Abstract Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that secretion regulated by a circular RNA containing the lariat sequence second intron gene. Silencing this intronic in islets leads decrease expression key components secretory machinery β-cells, resulting impaired glucose- or KCl-induced and calcium signaling. The effect exerted at transcriptional level involves an interaction with RNA-binding protein TAR...
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles physiology. In the liver of mammals, these are controlled by transcription–translation feedback loops core circadian clock and feeding–fasting cycles. To better understand regulatory interplay between feeding rhythms, we mapped DNase I hypersensitive sites (DHSs) mouse during a cycle. The intensity cleavages cycled at substantial fraction all DHSs, suggesting DHSs harbor elements control rhythmic...
Significance Rhythms in gene expression propelled by the circadian clock and environmental signals are ubiquitous across cells tissues. In particular, mouse tissues, thousands of transcripts show oscillations with a period 24 hours. Keys question how such rhythms propagate eventually exert functions, but also these generated. Here, we developed mathematical model based on total RNA-seq to classify genes according respective contributions transcriptional posttranscriptional regulation toward...
Significance Studies in mice and humans have revealed daytime variance exercise performance, yet it is still unclear whether how these differences are regulated by the circadian clock. Here, we show that performance clock controlled specific proteins modify capacity a time-dependent manner, likely through food consumption liver glycogen stores. We also demonstrate time of day at which training performed plays role improving capacity. Our study suggests shaped daytime-dependent manner.
Non-invasive oxygen saturation (SpO2) is a central vital sign used to shape the management of COVID-19 patients. Yet, there have been no report quantitatively describing SpO2 dynamics and patterns in patients using continuous recordings. We performed retrospective observational analysis clinical information 27 K hours high-resolution (1 Hz) recordings 367 critical non-critical hospitalised at Rambam Health Care Campus, Haifa, Israel. An absolute threshold 93% most efficiently discriminated...
Studies suggest that central venous catheter bloodstream infections (BSIs) increased during the COVID-19 pandemic. We investigated catheter-related BSIs in Switzerland and found peripheral (PVC) BSI incidence 2021-2022 compared with 2020. These findings should raise awareness of PVC-associated prompt inclusion PVC surveillance systems.
Abstract Context Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion; however, alterations in molecular pattern functional genes during tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns normal pathological glands (PGs) sporadic primary (HPT1) secondary hyperparathyroidism (HPT2). Objective To evaluate dynamic as a function type PG pathology, comparative transcript analysis was conducted subgroups healthy...
Abstract Background With the COVID-19 pandemic’s outbreak, millions flocked to Wikipedia for updated information. Amid growing concerns regarding an “infodemic,” ensuring quality of information is a crucial vector public health. Investigating whether and how remained up date in line with science key formulating strategies counter misinformation. Using citation analyses, we asked which sources informed Wikipedia’s COVID-19–related articles before during first wave (January–May 2020). Results...
tRNA-derived fragments (tRFs) are an emerging class of small non-coding RNAs with distinct cellular functions. Here, we studied the contribution tRFs to regulation postnatal β cell maturation, a critical process that may lead diabetes susceptibility in adulthood. We identified three abundant neonatal rat islets originating from 5' halves (tiRNA-5s) histidine and glutamate tRNAs. Their inhibition these reduced proliferation insulin secretion. Mitochondrial respiration was also perturbed,...
The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy diabetes. Current methodologies are inefficient, largely because a limited understanding the underlying mechanisms. Using an vitro system, we reveal transcriptional repressor RE-1 silencing transcription factor (REST) as barrier gene expression exocrine cells. We observe that REST-bound loci lie adjacent to binding sites multiple key...
Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering cell division cycle. We have used this system and H3K4me3, Pol II III profiling to characterize adaptations transcription. Our results broadly define a class of genes close H3K4me3 peaks, whose occupancy is high stable, another class, distant from strongly increases hepatectomy. regulation thus entails both highly expressed housekeeping expression can adapt increased demand.
Abstract Background As coronavirus disease 2019 (COVID-19) is integrated into existing infectious control programs, it important to understand the comparative clinical impact of COVID-19 and other respiratory diseases. Methods We conducted a retrospective cohort study patients with symptomatic healthcare-associated or influenza reported nationwide, hospital-based surveillance system in Switzerland. Included were adults (aged ≥18 years) hospitalized for ≥3 days tertiary care large regional...
<ns4:p>Next generation sequencing has radically changed research in the life sciences, both academic and corporate laboratories. The potential impact is tremendous, yet a majority of citizens have little or no understanding technological ethical aspects this widespread adoption. We designed BeerDeCoded as pretext to discuss societal issues related genomic metagenomic data with fellow citizens, while advancing scientific knowledge most popular beverage all. In spirit citizen science, sample...
<ns4:p>Next generation sequencing has radically changed research in the life sciences, both academic and corporate laboratories. The potential impact is tremendous, yet a majority of citizens have little or no understanding technological ethical aspects this widespread adoption. We designed BeerDeCoded as pretext to discuss societal issues related genomic metagenomic data with fellow citizens, while advancing scientific knowledge most popular beverage all. In spirit citizen science, sample...
Abstract Objective. Arrhythmia is an abnormal cardiac rhythm that affects the pattern and rate of heartbeat. Wearable devices with functionality to measure store heart (HR) data are growing in popularity enable diagnosing monitoring arrhythmia on a large scale. The typical sampling resolution HR available from non-medical grade wearable varies seconds several minutes depending device its settings. However, impact performance quality detection has not yet been quantified. Approach. In this...
Abstract Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and preceded by phase intense proliferation. These events occurring in the neonatal period are decisive for establishing an appropriate functional β-cell mass that provides required throughout life. However, key regulators gene expression involved maturation β-cells remain to be elucidated. Here, we addressed this issue mapping open chromatin regions newborn versus adult rat islets using...
Background: COVID-19 is a newly recognized illness with predominantly respiratory presentation. It important to characterize the differences in disease presentation and trajectory between patients other common illnesses. These can enhance knowledge of pathogenesis help guiding treatment. Methods: Data from electronic medical records were obtained individuals admitted illnesses Rambam Health Care Campus, Haifa, Israel, October 1st, 2014 2020. Four groups defined: (693), influenza (1,612),...
Jonathan Sobel is president and chair of the board directors American Academy PAs, senior administrative director PA Services at Northwell Health in New York City. The author has disclosed no other potential conflicts interest, financial or otherwise.
Background COVID-19 is a newly recognized illness with predominantly respiratory presentation. It important to characterize the differences in disease presentation and trajectory between patients other common illnesses. These can enhance knowledge of pathogenesis help guiding treatment. Methods Data from electronic medical records were obtained individuals admitted illnesses Rambam Health Care Campus, Haifa, Israel, October 1st, 2014 2020. Four groups defined: (693), influenza (1,612),...