A5050780818- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Microbial metabolism and enzyme function
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Parathyroid Disorders and Treatments
- Ferroptosis and cancer prognosis
- Medical Imaging and Pathology Studies
- Macrophage Migration Inhibitory Factor
- Medical Imaging Techniques and Applications
- Hormonal Regulation and Hypertension
- Metalloenzymes and iron-sulfur proteins
- Circular RNAs in diseases
- Radiopharmaceutical Chemistry and Applications
- interferon and immune responses
- Genetic Syndromes and Imprinting
- Glutathione Transferases and Polymorphisms
- Integrated Water Resources Management
- Head and Neck Anomalies
- Fibroblast Growth Factor Research
National Institutes of Health
2016-2025
National Cancer Institute
2016-2025
Center for Cancer Research
2014-2024
Geneva College
2019
University Hospital of Geneva
2012-2019
University of Geneva
2018-2019
Hôpital Beau-Séjour
2018
Heidelberg University
2016
National Institutes of Health Clinical Center
2014-2016
University of Crete
2016
Purpose Gastro-entero-pancreatic neuroendocrine tumors (GEPNETs) are increasing in incidence, and accurate staging is important for selecting the appropriate treatment. 68 Ga-DOTATATE imaging a promising approach detecting GEPNETs could help optimal therapeutic strategies. The aim of this study was to prospectively determine clinical utility positron emission tomography (PET)/computed (CT) unknown primary metastatic GEPNETs. Patients Methods One hundred thirty-one patients were enrolled...
Hypoparathyroidism, the most common complication after thyroid surgery, leads to hypocalcaemia and significant medical problems. An RCT was undertaken determine whether intraoperative parathyroid gland angiography with indocyanine green (ICG) could predict postoperative hypoparathyroidism, obviate need for systematic blood tests oral calcium supplementation.Between September 2014 February 2016, patients who had at least one well perfused on ICG were randomized receive standard follow-up...
Pheochromocytomas/paragangliomas overexpress somatostatin receptors, and recent studies have already shown excellent results in the localization of sympathetic succinate dehydrogenase complex, subunit <i>B</i>, mutation-related metastatic pheochromocytomas/paragangliomas using <sup>68</sup>Ga-DOTATATE PET/CT. Therefore, goal our study was to assess clinical utility this functional imaging modality parasympathetic head neck paragangliomas (HNPGLs) compared with anatomic CT/MRI other...
Abstract Background Postoperative hypoparathyroidism remains the most common complication following thyroidectomy. The aim of this pilot study was to evaluate use intraoperative parathyroid gland angiography in predicting normal function after thyroid surgery. Methods Angiography with fluorescent dye indocyanine green (ICG) performed patients undergoing total thyroidectomy, visualize vascularization identified glands. Results Some 36 underwent ICG during All received standard calcium and...
Phosphaturic mesenchymal tumors (PMTs) are small, typically difficult to localize, and express somatostatin receptors. Recent work suggests imaging studies using 68Gallium (68Ga)-conjugated peptide analogues, such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)TATE, which enables receptor with positron emission tomography (PET), may be useful at identifying these tumors.Our objective was evaluate the use of 68Ga-DOTATATE PET/computed (CT) for tumor localization in...
Reliable localization of insulinoma is critical for successful treatment.This study compared the accuracy 68Gallium DOTA-(Tyr3)-octreotate (Ga-DOTATATE) positron emission tomography (PET)/computed (CT) to anatomic imaging modalities, selective arterial secretagogue injection (SASI), and intraoperative ultrasound (IO ultrasound) palpation localizing in patients who were biochemically cured.We conducted a retrospective analysis 31 had an insulinoma. The results CT, magnetic resonance (MRI),...
To report long-term follow-up of patients with multiple endocrine neoplasia type 1 (MEN1) and nonfunctioning pancreatic neuroendocrine tumors (NF-PET).Pancreaticoduodenal occur in almost all MEN1 are a major cause death. The natural history clinical outcome poorly defined, management is still controversial for small NF-PET.Clinical tumor progression were analyzed 46 2 cm or smaller NF-PET who did not have surgery at the time initial diagnosis. Survival data using Kaplan-Meier...
One of the worst complications in thyroid surgery is bilateral recurrent laryngeal nerve paralysis, which can lead to transient or definitive tracheotomy.We implemented a strict standard operative procedure beginning January 2010 and modified our procedure. In all patients undergoing operation, we begin with largest side cancerous/suspicious without dissecting contralateral side. If intraoperative neuromonitoring (IONM) signal lost after stimulation vagus at end first side, stop unilateral...
AIM:To study the safety of epidural anesthesia (EA), its effect on pancreatic perfusion and outcome patients with acute pancreatitis (AP). METHODS:From 2005 to August 2010, predicted severe AP [Ranson score ≥ 2, C-reactive protein > 100 or necrosis computed tomography (CT)] were prospectively randomized either a group receiving EA control treated by patient Randomized Clinical Trial ORIGINAL ARTICLE RESULTS:We enrolled 35 patients.Thirteen 22 group.There no differences in demographic...
Patients with von Hippel-Lindau (VHL) syndrome have a 25-30% chance of developing pheochromocytoma. Although practice guidelines recommend biochemical and radiological screening every 1-2 years for pheochromocytoma in patients VHL, there are limited data on the optimal age frequency screening.Our objective was to determine earliest onset contralateral recurrent pheochromocytomas VHL syndrome.This is retrospective analysis prospective cohort enrolled natural history study.A total 273...
Abstract Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies, but its genetic drivers remain little understood. In this study, we report losses in expression miRNA miR30a, which downregulated ATC compared with differentiated and normal tissue. miR30a downregulation was associated advanced higher mortality. Mechanistically, found decreased cellular invasion migration, epithelial–mesenchymal transition marker levels, lysyl oxidase (LOX) expression, metastatic capacity....
Abstract Major complications of thyroid and parathyroid surgery are recurrent laryngeal nerve injuries definitive hypoparathyroidism. The use intra‐operative Indocyanine Green Angiography for confirmation vascular status the gland is reported here.
This study evaluates the natural history of von Hippel–Lindau disease–associated pancreatic lesions to determine factors associated with neuroendocrine tumor phenotype and prognosis.
Epithelial-to-mesenchymal transition (EMT) is important in cancer progression and metastasis. We others have previously reported that lysyl oxidase (LOX) overexpressed aggressive cancers, associated with increased mortality, regulates EMT. However, the mechanism by which LOX mediates EMT unknown. In this study, we investigated effect of on mediators EMT.We used chromatin immunoprecipitation promoter luciferase assays to determine target gene LOX. To effects SNAI2 vivo, our metastatic...
Valproic acid (VA) is a histone deacetylase (HDAC) inhibitor that has antiproliferative effects on several types of cancer, including thyroid cancer. In addition, VA been reported to upregulate the sodium-iodine symporter in cancer cells and increases radioiodine uptake preclinical studies. The aim this study was assess evaluate if can increase patients with advanced, radioiodine-negative cancer.An open-label Simon two-stage phase II trial.Valproic administered orally, doses were adjusted...
Background: Although a family history of thyroid cancer is one the main risk factors for cancer, benefit screening individuals with not known. Methods: A prospective cohort study was performed yearly using neck ultrasound and fine-needle aspiration biopsy nodule(s) >0.5 cm in at-risk whose relatives were diagnosed familial non-medullary (FNMTC). The eligibility criteria presence two or more first-degree being older than seven years age. Twenty-five kindred enrolled (12 families members...