A5031777285- Mass Spectrometry Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Gastroesophageal reflux and treatments
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Chromatography
- Bone health and osteoporosis research
- Esophageal Cancer Research and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Advanced Chemical Sensor Technologies
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging and Pathology Studies
- Adrenal and Paraganglionic Tumors
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Growth Hormone and Insulin-like Growth Factors
- Analytical chemistry methods development
- Parathyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Clinical Nutrition and Gastroenterology
Loughborough University
2016-2025
National Institutes of Health Clinical Center
2015-2025
National Institutes of Health
2009-2024
University of Pennsylvania
1987-2023
University of Pennsylvania Health System
2020
Hospital of the University of Pennsylvania
1982-2019
Alfred Health
2019
Monash University
2019
Drexel University
2006-2016
Hahnemann University Hospital
1998-2016
Obesity is a growing problem in the United States and throughout world. It risk factor for many chronic diseases. The BMI has been used to assess body fat almost 200 years. known be of limited accuracy, different males females with similar %body adiposity. Here, we define an alternative parameter, adiposity index (BAI = ((hip circumference)/((height)(1.5))-18)). BAI can reflect adult men women differing ethnicities without numerical correction. We population study, "BetaGene" develop new...
This report summarises conclusions from an evidence-based workshop which evaluated major clinical strategies for the management of full spectrum gastro-oesophageal reflux disease, with emphasis on medical management.The disease was defined by presence oesophageal mucosal breaks or occurrence induced symptoms severe enough to impair quality life.Endoscopy negative patients were recognised as most common subgroup; these can be diagnosed a well structured symptom analysis.There is consistent...
Hutchinson–Gilford progeria syndrome is a rare, sporadic, autosomal dominant that involves premature aging, generally leading to death at approximately 13 years of age due myocardial infarction or stroke. The genetic basis most cases this change from glycine GGC GGT in codon 608 the lamin A (LMNA) gene, which activates cryptic splice donor site produce abnormal A; disrupts nuclear membrane and alters transcription.
Abstract Several previous reports of small cohorts have found significantly higher serum 1,25-dihydroxy vitamin D (1,25-vit D) in obese compared with nonobese whites. Based on these and recent vitro studies adipocytes which suggest that administration 1,25-vit can stimulate lipogenesis inhibit lipolysis, some investigators proposed high may play a role promoting or maintaining adipocyte triglyceride stores adults. To test the hypothesis obesity is commonly associated increased D, we examined...
To detect recurrent disease in patients who have had differentiated thyroid cancer, periodic withdrawal of hormone therapy may be required to raise serum thyrotropin concentrations stimulate tissue so that radioiodine (iodine-131) scanning can performed. However, causes hypothyroidism. Administration recombinant human stimulates without requiring the discontinuation therapy.
Depression is associated with alterations in behavior and neuroendocrine systems that are risk factors for decreased bone mineral density. This study was undertaken to determine whether women past or current major depression have demonstrable decreases density.We measured density at the hip, spine, radius 24 normal matched age, body-mass index, menopausal status, race, using dual-energy x-ray absorptiometry. We also evaluated cortisol growth hormone secretion, metabolism, vitamin D-receptor...
Objective: To compare the sensitivity of somatostatin receptor scintigraphy done using [111In-DTPA-DPhe1]octreotide with that other imaging methods in localization gastrinomas patients Zollinger-Ellison syndrome. Design: Prospective study. Setting: Referral-based clinical research center. Patients: 80 consecutive Interventions: Conventional tumor studies (ultrasonography, computed tomography [CT], magnetic resonance [MRI], selective angiography, and bone scanning) single-photon emission CT...
BACKGROUND. Monogenic IFN–mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN response gene signature, inflammatory organ damage, and high mortality. We used the JAK inhibitor baricitinib, IFN-blocking activity vitro, to ameliorate disease.
OBJECTIVE. Few studies have quantified the prevalence of weight-related orthopedic conditions in otherwise healthy overweight children. The goal present investigation was to describe musculoskeletal consequences pediatric a large cohort children that included severely METHODS. Medical charts from 227 and 128 nonoverweight adolescents who were enrolled clinical at National Institutes Health 1996 2004 reviewed record pertinent medical history complaints. Questionnaire data 183 enrollees (146...
Patients with congenital adrenal hyperplasia (CAH) often suffer from long-term complications secondary to chronic glucocorticoid therapy and suboptimal treatment regimens.
In patients with advanced chemotherapy-refractory mesothelioma, treatment the anti-mesothelin immunotoxin SS1P and immunosuppression pentostatin cyclophosphamide resulted in marked durable tumor regressions.
Seventeen patients with papillary thyroid cancer whose serum thyroglobulin (Tg) levels were elevated when hypothyroid, but diagnostic whole body scans negative, treated 150-300 mCi 131I. All had total thyroidectomy and 131I ablation for remnants. Before the study, 9 therapy tumor recurrence and/or metastases, 5 excisions of nonfunctioning metastasis. Radiological studies did not reveal evidence metastases. In initial evaluation, Tg ranged from 8-480 ng/mL (24 pmol/L to 1.5 nmol/L),...
Background: Troglitazone promotes adipocyte differentiation in vitro and increases insulin sensitivity vivo. Therefore, troglitazone may have therapeutic benefit lipoatrophic diabetes. Objective: To determine whether ameliorates hyperglycemia hypertriglyceridemia or fat mass patients. Design: Open-labeled prospective study. Setting: United States Canada. Patients: 20 patients with various syndromes associated lipoatrophy lipodystrophy. Intervention: 6 months of therapy troglitazone, 200 to...
Hypoparathyroidism is one of the few remaining hormonal insufficiency states for which replacement therapy unavailable. Previous short-term controlled trials have shown PTH to be a safe and effective treatment hypoparathyroidism. In this randomized, parallel group, open-label trial, we compared synthetic human PTH-(1-34) (PTH) with conventional therapy, calcitriol calcium, over 3-yr period. Twenty-seven patients confirmed hypoparathyroidism, aged 18-70 yr, were randomized either twice daily...
Families with von Hippel-Lindau disease have variable risk of pheochromocytoma. Patients and pheochromocytoma identified by screening can no characteristic signs or symptoms. were screened followed to describe the natural history pheochromocytoma, correlate these findings germline mutation.Between 1988 1997, 246 individuals (von group). Between August 1990 June 26 consecutive patients sporadic evaluated (sporadic group).A total 64 had manifestations including 33 newly diagnosed during at...
Little is known of the natural history thymic carcinoids in multiple endocrine neoplasia type 1 (MEN1). This important because 1993 they were identified as a frequent cause death, yet only small retrospective studies and case reports exist. We report results prospective study 85 patients with MEN1 evaluated for pancreatic tumors followed over mean 8 yr serial chest computed tomography, magnetic resonance imaging (MRI), x-ray, and, since 1994, octreoscans [somatostatin receptor scintigraphy...
A retrospective study of 56 patients upon whom 76 inter-digital neuromas were excised was carefully evaluated. There 53 females and 3 males, with an average age 55 years. The main preoperative symptom pain in the plantar aspect foot which increased by walking relieved rest. physical finding that tenderness involved interspace. equal number interdigital neu-romas removed from second third Postoperatively 65% still noted some local tenderness, 68% numbness 80% subjectively improved.
Abstract Bisphosphonates have been widely administered to children with OI based on observational trials. A randomized controlled trial of q3m intravenous pamidronate in types III and IV yielded positive vertebral changes DXA geometry after 1 year treatment, but no further significant improvement during extended treatment. The treated group did not experience significantly decreased pain or long bone fractures increased motor function muscle strength. Introduction: Bisphosphonates,...
Context: Osteoporosis primarily affects postmenopausal women. However, young women with estrogen deficiency also are at increased risk for low bone density.
OBJECTIVE Metformin can decrease adiposity and ameliorate obesity-related comorbid conditions, including abnormalities in glucose homeostasis adolescents, but there are few data evaluating the efficacy of metformin among younger children. Our objective was to determine whether treatment causes weight loss improves comorbidities obese children, who insulin-resistant. RESEARCH DESIGN AND METHODS This study a randomized double-blind placebo-controlled trial consisting 100 severely (mean BMI...