A5020268823- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- Reproductive System and Pregnancy
- HIV/AIDS Research and Interventions
- Reproductive Health and Contraception
- Gut microbiota and health
- Syphilis Diagnosis and Treatment
- Urinary Tract Infections Management
- Maternal and Perinatal Health Interventions
- Reproductive Health and Technologies
- Reproductive Physiology in Livestock
- Cervical Cancer and HPV Research
- Preterm Birth and Chorioamnionitis
- Global Maternal and Child Health
- Herpesvirus Infections and Treatments
- Maternal and fetal healthcare
- Gender Politics and Representation
- Inflammatory mediators and NSAID effects
- Clostridium difficile and Clostridium perfringens research
- Urban, Neighborhood, and Segregation Studies
- Place Attachment and Urban Studies
- Autoimmune Bullous Skin Diseases
- Sex and Gender in Healthcare
- Pharmacovigilance and Adverse Drug Reactions
- Obesity and Health Practices
University of California, Berkeley
2005-2024
Berkeley Public Health Division
2018-2024
Ibis Reproductive Health
2010-2024
University of California, San Francisco
2013-2024
Public Health Institute
2018-2020
University of California, San Diego
2020
Osel (United States)
2020
Emmes (United States)
2020
Ruth M. Rothstein CORE Center
2020
Rush University Medical Center
2020
Bacterial vaginosis affects 15 to 50% of women reproductive age, and recurrence is common after treatment with an antibiotic agent. The high incidence suggests the need for new treatments prevent recurrent bacterial vaginosis.
Background. Bacterial vaginosis (BV) causes genital inflammation and increases HIV risk, whereas a vaginal microbiota dominated by Lactobacillus species is associated with immune quiescence relative protection. BV treatment reduces inflammation, but it unclear whether this reduction driven decrease in BV-associated bacteria or an increase species.
In Brief Background: Bacterial vaginosis (BV) is a common vaginal infection caused by lack of endogenous lactobacilli and overgrowth pathogens that frequently recurs following antibiotic treatment. Methods: A phase 2a study assessed colonization efficiency, safety, tolerability, acceptability Lactobacillus crispatus CTV-05 (LACTIN-V) administered applicator. Twenty-four women with BV were randomized in 3:1 ratio active product to placebo. Participants used LACTIN-V at 2 × 109 colony-forming...
Objective To validate anecdotal reports that abortion‐related complications decreased in the Dominican Republic after introduction of misoprostol into country. Design Retrospective records reviews and cross‐sectional surveys, interviews focus groups. Setting Family planning clinics, pharmacies, door‐to‐door canvassing a tertiary care maternity hospital Santo Domingo, Republic. Population Women reproductive age Methods Qualitative quantitative methods were used. Individual groups health...
Several fastidious bacteria have been associated with bacterial vaginosis (BV), but their role in lactobacilli recolonization failure is unknown. We studied the effect of 7 BV-associated species and 2 Lactobacillus on vaginal colonization crispatus CTV-05 (LACTIN-V).Twenty-four women BV were given a 5-day course metronidazole gel then randomized 3:1 to receive either LACTIN-V or placebo applied vaginally once daily for 5 initial consecutive days, followed by weekly application over weeks....
Although physicians are expected to provide dietary counseling for patients with cardiovascular (CV) risk factors such as hypertension, hyperlipidemia, diabetes, and obesity, nutrition education in graduate medical remains limited. Few studies have recently examined practices Internal Medicine (IM) residency training.To conduct a contemporary assessment of outpatient IM programs the United States, identify predictors residents' CV factors, barriers educators providing residents...
ABSTRACT Vaginal colonization by fungi may elicit genital inflammation and enhance the risk of adverse reproductive health outcomes, such as HIV acquisition. Cross-sectional studies have linked with an absence bacterial vaginosis (BV), but it is unclear whether shifts in vaginal bacteria alter abundance fungi. swabs collected following topical metronidazole treatment for BV during phase 2b, placebo-controlled trial LACTIN-V, a Lactobacillus crispatus -based live biotherapeutic, were assayed...
Introduction Live biotherapeutic products (LBPs) containing Lactobacillus crispatus may optimize the vaginal microbiota, reduce genital inflammation, and protect against HIV acquisition. Determining acceptability of LBPs among African women at high risk is essential to guide product development. Methods The phase 2 double-blind randomized placebo-controlled trial recruited young sexually active cis-women with dysbiosis from a community-based research clinic. Following antibiotics (oral...
Women worldwide confront two frequently concurrent reproductive health challenges: the need for contraception and protection from sexually transmitted infections, importantly HIV/AIDS. While conception infection share same anatomical site mode of transmission, there are no technologies to date that simultaneously address reality. Relevant available either contraceptive or anti-infective, limited in number, require different modes administration management. These “single-indication” do not...
Abstract Background Bacterial vaginosis (BV) increases HIV acquisition risk, potentially by eliciting genital inflammation. After BV treatment, the vaginal administration of LACTIN-V, a live biotherapeutic containing Lactobacillus crispatus strain CTV-05, reduced recurrence and inflammation; however, 3 months after product cessation, CTV-05 colonization was only sustained in 48% participants. Results This nested sub-study 32 participants receiving LACTIN-V finds that 72% (23/32) demonstrate...
In Brief Background: Bacterial vaginosis is a very common vaginal infection. The lack of endogenous lactobacilli and overgrowth pathogens facilitate numerous gynecological complications. Methods: A phase I dose-ranging safety trial tested the safety, tolerability, acceptability Lactobacillus crispatus CTV-05 (LACTIN-V) administered by applicator. Twelve healthy volunteers were enrolled in 3 blocks 4 (5 × 108, 1 109, 2 109 cfu/dose). Each block was randomized 3:1 ratio active product to...
Hydroxychloroquine (HCQ) is a cornerstone to managing systemic lupus erythematosus (SLE), yet adherence medication poor. We sought measure the association of with 5 "dimensions adherence" as articulated by World Health Organization for chronic conditions: patient's socioeconomic status, and patient-, condition-, therapy-, healthcare system-related factors. Our longterm goal generate evidence design effective interventions increase adherence.The retrospective cohort study included Kaiser...
The majority of catamnestic studies on successful IVF treatment deal with the development children and parent-child-relationship. Far fewer pay attention to changes within relationship couples that become parents. This particular study focused transition from partnership parenthood assessments at different measuring points (T1: last trimester pregnancy; T2: 3 months after birth; T3: 12 birth) compared 47 45 conceived naturally. were observed psychodynamic couple interviews standardized as...
Abstract A Lactobacillus-dominated vaginal microbiota (VMB) has been associated with health and considered an important host defense mechanism against urogenital infections. Conversely, depletion of lactobacilli increased microbial diversity, amplifies the risk adverse gynecologic obstetric outcomes. common clinical condition that exemplifies dysbiosis is bacterial vaginosis (BV). BV currently treated antibiotics, but frequently recurs, due in part to persistent failure repopulate vagina....
Abstract Background Bacterial vaginosis (BV) is a proinflammatory genital condition associated with adverse reproductive health outcomes, including increased HIV incidence. However, BV recurrence rates are high after standard antibiotic treatment. While the composition of vaginal microbiota before treatment may be linked to recurrence, it unclear whether preceding immune milieu predictive success. Methods Here we assessed baseline soluble factors or predicted success 1 month metronidazole in...
In Germany, four years of experience with mifepristone as an alternative procedure to surgical abortion have revealed a still reluctant use the new method. public discussion, more participatory role women in is often feared negative consequences for emotional processing event. This study compares women's criteria selecting method and psychological responses before weeks after medical or abortion. Two hundred nineteen answered questions regarding demographic data, motivation, details social...
Objective: Lime has a long history as contraceptive and vaginal hygiene douche, ongoing use in Africa is documented. We report on the first safety study diluted lime juice to assess its potential candidate microbicide. Methods: Twenty-five sexually abstinent women were randomly assigned apply 10% or 20% concentration of 0% (water-only) through soaked tampon once daily for 14 consecutive days. Tests genital infections, measurement inflammatory biomarkers, colposcopy performed before after...
Multipurpose prevention technologies (MPTs) are an innovative class of products that deliver varied combinations human immunodeficiency virus (HIV) prevention, other sexually transmitted infection (STI) and contraception. Combining separate strategies for different indications into singular can reduce the stigma around HIV STI improve acceptability adherence to more convenient products, be cost-effective by addressing overlapping risks.This article outlines a strategic action framework...
Objectives Live biotherapeutic products (LBPs) containing vaginal Lactobacillus crispatus are promising adjuvant treatments to prevent recurrent bacterial vaginosis (BV) but may depend on the success of initial antibiotic treatment. Methods A post hoc analysis data collected during phase 2b LACTIN-V randomized control trial ( L. CTV-05) explored impact clinical BV cure defined as Amsel criteria 0 3 (excluding pH, per 2019 Food and Drug Administration guidance) 2 days after completion...
Participatory research involving communities, especially women, is increasingly recognized as a valuable and scientifically sound approach to improve the relevance of study, accuracy data collection interpretation, adherence study procedures, likelihood adopting any resulting intervention. This has interdisciplinary roots dating back more than half century. Although widely used in community-based conservation development projects worldwide, international public health yet fully embrace this...