Aruna Bhoola
A5035245790- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Statistical Methods in Clinical Trials
- Reproductive tract infections research
- Sex work and related issues
- Ethics in Clinical Research
Aurum Institute
2021-2025
South African Medical Research Council
2021
Introduction Live biotherapeutic products (LBPs) containing Lactobacillus crispatus may optimize the vaginal microbiota, reduce genital inflammation, and protect against HIV acquisition. Determining acceptability of LBPs among African women at high risk is essential to guide product development. Methods The phase 2 double-blind randomized placebo-controlled trial recruited young sexually active cis-women with dysbiosis from a community-based research clinic. Following antibiotics (oral...
Safe practices for dispensing investigational product (IP) during clinical trials are not standardized and information in this regard is often limited. ASPIRE was a Phase 3 safety effectiveness trial of vaginal matrix ring containing 25 mg dapivirine the prevention HIV-1 women. The study enrolled 2629 women at 15 research sites Malawi, Uganda, South Africa Zimbabwe who were randomized 1:1 ratio to receive either or matching placebo ring. rings packaging identical appearance order maintain...