Michael J. Lanspa
A5061729657- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Smoking Behavior and Cessation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Long-Term Effects of COVID-19
- Heart Rate Variability and Autonomic Control
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Function and Risk Factors
- Renal function and acid-base balance
- Emergency and Acute Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Systems, Economic Evaluations, Quality of Life
- Dysphagia Assessment and Management
- Mechanical Circulatory Support Devices
- Non-Invasive Vital Sign Monitoring
- Healthcare cost, quality, practices
- Esophageal and GI Pathology
- Pneumonia and Respiratory Infections
Intermountain Medical Center
2016-2025
META Group
2025
Analysis Group (United States)
2025
University of Utah
2015-2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2024
American Society of Echocardiography
2024
National Heart Lung and Blood Institute
2015-2024
Intermountain Healthcare
2012-2024
Velocity Clinical Research (United States)
2024
University of California, San Francisco
2015-2023
An ongoing pandemic of COVID-19 that started in Hubei, China has resulted massive strain on the healthcare infrastructure Lombardy, Italy. The management these patients is still evolving.
RATIONALE: Maintaining glycemic control of critically ill patients may impact outcomes such as survival, infection, and neuromuscular recovery, but there is equipoise on the target blood levels, monitoring frequency, methods. OBJECTIVES: The purpose was to update 2012 Society Critical Care Medicine American College (ACCM) guidelines with a new systematic review literature provide actionable guidance for clinicians. PANEL DESIGN: total multiprofessional task force 22, consisting clinicians...
BACKGROUND Aspiration pneumonia is a common syndrome, although less well characterized than other syndromes. We describe large population of patients with aspiration pneumonia. METHODS In this retrospective study, we queried the electronic medical records at tertiary‐care, university‐affiliated hospital from 1996 to 2006. Patients were initially identified by International Classification Diseases, 9th Revision code 507.x; subsequent physician chart review excluded pneumonitis and those...
In the Fluid and Catheter Treatment Trial (FACTT) of National Institutes Health Acute Respiratory Distress Syndrome Network, a conservative fluid protocol (FACTT Conservative) resulted in lower cumulative balance better outcomes than liberal Liberal). Subsequent Network studies used simplified Lite). The objective this study was to compare performance FACTT Lite, Conservative, Liberal protocols.
Left ventricular diastolic dysfunction is common in patients with severe sepsis or septic shock, but the best approach to categorization unknown. We assessed association of measures function clinical outcomes and tested utility a simplified definition against American Society Echocardiography (ASE) 2009 definition.In this prospective observational study, shock underwent transthoracic echocardiography within 24 h onset (median 4.3 h). measured echocardiographic parameters used random forest...
Importance Preclinical models suggest dysregulation of the renin-angiotensin system (RAS) caused by SARS-CoV-2 infection may increase relative activity angiotensin II compared with (1-7) and be an important contributor to COVID-19 pathophysiology. Objective To evaluate efficacy safety RAS modulation using 2 investigational agents, TXA-127 (synthetic [1-7]) TRV-027 (an type 1 receptor–biased ligand), that are hypothesized potentiate action mitigate II. Design, Setting, Participants Two...
Despite the growing use of point care ultrasound (POCUS) in contemporary medical practice and existence clinical guidelines addressing its specific applications, there remains a lack standardization agreement on optimal practices for several areas POCUS use. The Society Point Care Ultrasound (SPOCUS) formed working group 2022 to establish set recommended best POCUS, applicable clinicians regardless their training, specialty, resource setting, or scope practice. Using three-round modified...
RATIONALE: Critical care ultrasonography (CCUS) is rapidly evolving with new evidence being published since the prior 2016 guideline. OBJECTIVES: To identify and assess best regarding clinical outcomes associated five CCUS applications in adult patients publication of previous guidelines. PANEL DESIGN: An interprofessional, multidisciplinary, diverse expert panel 36 individuals including two patient/family representatives was assembled via an intentional approach. Conflict-of-interest...
Patients with severe sepsis or septic shock often exhibit significant cardiovascular dysfunction. We sought to determine whether severity of diastolic dysfunction assessed by transthoracic echocardiography (TTE) predicts 28-day mortality. In this prospective, observational study conducted in two intensive care units at a tertiary hospital, 78 patients (age 53.2 ± 17.1 years; 51% females; mean APACHE II score 23.3 7.4) underwent TTE within 6 h ICU admission, after 18 32 h, and resolution...
Abstract Introduction Both patient- and context-specific factors may explain the conflicting evidence regarding glucose control in critically ill patients. Blood variability appears to correlate with mortality, but this be an indicator of disease severity, rather than independent predictor mortality. We assessed blood coefficient variation as mortality ill. Methods used eProtocol-Insulin, electronic protocol for managing intravenous insulin explicit rules, high clinician compliance,...
BackgroundIn addition to hyperglycemia, hypoglycemia, and glycemic variability, reduced time in targeted blood glucose range (TIR) is associated with increased risk of death critically ill patients. This relation between TIR mortality may be confounded by diabetic status antecedent control.MethodsThis study retrospectively analyzed patients managed the same IV insulin protocol at multiple centers. The percentage 70 139 mg/dL was calculated. Patients ketoacidosis, who had < 10 readings,...
Objectives: The objectives of this study were to: 1) determine the association between vasopressor dosing intensity during first 6 hours and 24 after onset septic shock 30-day in-hospital mortality; 2) whether effect varies by fluid resuscitation volume; 3) titration pattern. Design: Multicenter prospective cohort September 2017 February 2018. Vasopressor was defined as total dose infused across all vasopressors in norepinephrine equivalents. Setting: Thirty-three hospital sites United...