A5047437197- Complement system in diseases
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
- Hemoglobinopathies and Related Disorders
- Adolescent Sexual and Reproductive Health
- Chronic Lymphocytic Leukemia Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Homelessness and Social Issues
- Iron Metabolism and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Youth Development and Social Support
- Venous Thromboembolism Diagnosis and Management
- Health disparities and outcomes
- Ovarian cancer diagnosis and treatment
- Food Security and Health in Diverse Populations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Smoking Behavior and Cessation
- Endometrial and Cervical Cancer Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Adenosine and Purinergic Signaling
- Trypanosoma species research and implications
- Blood disorders and treatments
- Gender, Labor, and Family Dynamics
University of Oklahoma Health Sciences Center
2016-2025
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Children's Healthcare of Atlanta
2023-2024
Icahn School of Medicine at Mount Sinai
2024
National Institutes of Health
2024
University of Central Oklahoma
2024
University of Oklahoma
2013-2024
Hudson Institute
2024
University of Utah
2023
Emory University
2023
Abstract Background: Despite an increase in the number of therapies available to treat patients with immune thrombocytopenia (ITP), there are minimal data from randomized trials assist physicians management patients. Objective: These evidence-based guidelines American Society Hematology (ASH) intended support patients, clinicians, and other health care professionals their decisions about ITP. Methods: In 2015, ASH formed a multidisciplinary guideline panel that included 8 adult clinical...
Our objective was to describe new observations from the Oklahoma Thrombotic Thrombocytopenic Purpura (TTP) Registry experience (November 1995 through December 2015) on diagnosis of TTP along with patients' clinical features and their outcomes. Among 363 patients an initial episode clinically suspected TTP, supported by both ADAMTS13 activity <10% in 78 (21%). measured all 2 methods: fluorescence resonance energy transfer (FRET) immunoblotting (IB). Sixty had methods, 15 only FRET, 3 IB. Five...
Abstract Background Thrombotic thrombocytopenic purpura (TTP) associated with severe, acquired ADAMTS13 deficiency is uncommonly reported in children. The incidence, demographic, and clinical features of these children, compared to adults, have not been described. Procedures This study focused on children (<18 years old) adults TTP deficiency, defined as activity <10%. incidence rates for were calculated from patients enrolled the Oklahoma TTP–HUS (Hemolytic–Uremic syndrome) Registry,...
Despite an increase in our understandings of pathogenesis thrombotic thrombocytopenic purpura (TTP), the approaches for initial diagnosis and management TTP vary significantly.The evidence-based guidelines International Society on Thrombosis Haemostasis (ISTH) are intended to support patients, clinicians, other health care professionals their decisions about acute TTP.In June 2018, ISTH formed a multidisciplinary panel that included hematologists, intensive physician, nephrologist, clinical...
Platelet counts of less than 150,000 per cubic millimeter during uncomplicated pregnancies are described as gestational thrombocytopenia if no alternative cause is identified. may be even lower in women with pregnancy-related complications. However, the occurrence and severity throughout pregnancy not defined.
Abstract Objective Calibration and discrimination indicators alone are insufficient for evaluating the clinical usefulness of prediction models, as they do not account cost misclassification errors. This study aimed to modify Geriatric Trauma Outcome Score (GTOS) assess utility modified model using net benefit (NB) decision curve analysis (DCA) predicting in‐hospital mortality. Methods The Quality Improvement Program (TQIP) 2017 was used identify geriatric trauma patients (≥ 65 years)...
Low-dose oral vitamin K decreases the international normalized ratio (INR) in overanticoagulated patients who receive warfarin therapy. Its effects on bleeding events are uncertain. To see whether low-dose reduces over 90 days with warfarin-associated coagulopathy. Multicenter, randomized, placebo-controlled trial. Randomization was computer-generated, and participants were allocated to trial groups by using sequentially numbered study drug containers. Patients, caregivers, those assessed...