A5011260014- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood Coagulation and Thrombosis Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Hemophilia Treatment and Research
- Intramuscular injections and effects
- Blood properties and coagulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood transfusion and management
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
- Liver Disease and Transplantation
- Complement system in diseases
- Acute Myocardial Infarction Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Liver Disease Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Blood donation and transfusion practices
- Case Reports on Hematomas
- Aortic Thrombus and Embolism
- Clinical Laboratory Practices and Quality Control
University of Lausanne
2016-2025
University Hospital of Lausanne
2015-2024
University Hospital of Bern
2008-2023
University of Bern
2008-2023
Universitätsmedizin Greifswald
2023
Universitätsklinikum des Saarlandes
2023
Heidelberg University
2023
University Hospital Heidelberg
2023
Mexican Social Security Institute
2023
Sociedad Española de Trombosis y Hemostasia
2023
Cardiopulmonary bypass (CPB) is often associated with degrees of complex inflammatory response mediated by various cytokines. This can, in severe cases, lead to systemic hypotension and organ dysfunction. Cytokine removal might therefore improve outcomes patients undergoing cardiac surgery. CytoSorb® (Cytosorbents, NJ, USA) a recent device designed remove cytokine from the blood using haemoadsorption (HA). trial aims evaluate potential decrease peri-operative levels We have conducted...
Platelet-activating anti-platelet factor 4 (PF4)/heparin antibodies and anti-PF4 cause heparin-induced thrombocytopenia (HIT) vaccine-induced immune thrombosis (VITT), respectively. Diagnostic treatment considerations differ somewhat between HIT VITT. We identified patients with without proximate heparin exposure or adenovirus-based vaccination who tested strongly positive by PF4/polyanion enzyme-immunoassays negative/weakly platelet activation (HIPA) test but PF4-induced (PIPA) (ie,...
We report the largest international study on Glanzmann thrombasthenia (GT), an inherited bleeding disorder where defects of ITGA2B and ITGB3 genes cause quantitative or qualitative αIIbβ3 integrin, a key mediator platelet aggregation. Sequencing coding regions splice sites both in members 76 affected families identified 78 genetic variants (55 novel) suspected to GT. Four large deletions duplications were found by real-time PCR. Families with mutations either gene indistinguishable terms...
Essentials The utility of bleeding assessment tools regarding platelet function disorders is still elusive. We studied consecutive patients in a prospective cohort study tertiary hospital. Substantially higher scorings were observed with disorders. Bleeding might provide useful screening tool.Bleeding (BATs) have been widely implemented the evaluation suspected However, diagnostic BAT elusive.We aimed to assess value International Society on Thrombosis and Haemostasis (ISTH-BAT) for clinical...
Importance Venous thromboembolism (VTE) is a leading cause of morbidity and mortality after bariatric surgery. Clinical end point studies on thromboprophylaxis with direct oral anticoagulants in patients undergoing surgery are lacking. Objective To assess the efficacy safety prophylactic dose 10 mg/d rivaroxaban for both 7 28 days Design, Setting, Participants This assessor-blinded, phase 2, multicenter randomized clinical trial was conducted from July 1, 2018, through June 30, 2021,...