A5011560931- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Venous Thromboembolism Diagnosis and Management
- Hepatitis C virus research
- Antiplatelet Therapy and Cardiovascular Diseases
- Nutrition and Health in Aging
- Cardiac Ischemia and Reperfusion
- Drug-Induced Hepatotoxicity and Protection
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Hemophilia Treatment and Research
- Electrolyte and hormonal disorders
- Atrial Fibrillation Management and Outcomes
- Parathyroid Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Calpain Protease Function and Regulation
University of Lausanne
2022-2025
Mexican Social Security Institute
2023
University of North Carolina at Chapel Hill
2023
Sociedad Española de Trombosis y Hemostasia
2023
Cirrhosis is associated with a procoagulant state that may worsen disease evolution. Anticoagulation could be of particular interest in these patients. However, evidence on the use DOAC patients cirrhosis limited. Our aim was to explore vitro effect thrombin generation (TG) plasma from compared healthy controls. Platelet-poor-plasma obtained (n=87; Child-Turcotte-Pugh score: A n=68; B n=14; C n=5) and controls (n=17). TG assessed ST-Genesia. Plasma TM-mediated inhibition endogenous potential...
Introduction Decreased or enhanced procoagulant platelet generation may lead to bleeding thrombotic events, respectively. The intracellular program underlying the dichotomous of aggregating (AGG) and (COAT) platelets upon combined activation by Collagen-And-Thrombin is only partially described. In this study, we investigated utility timelapse phosphoproteomics identify potential early regulators response further describe phenotype.
Introduction Liver cirrhosis (LC) is a complex condition that associated, among others, with prothrombotic state and episodes of decompensation. While hypercoagulability secondary to the altered equilibrium in coagulation factors, causes liver decompensation are multiple. The aim this study investigate relationship between hemostatic parameters anDariusd occurrence LC
Introduction Liver cirrhosis (LC) induces alterations in haemostatic systems usually favour of a prothrombotic state. The effect direct oral anticoagulants (DOAC) this population remains to be investigated. "one dose fits all" approach used for DOAC might not always adequate patients with complex conditions, as highlighted triple positive antiphospholipid syndrome [1] [2]. With rationale, we aimed compare the anticoagulant (anti-Xa inhibitors) on ex vivo thrombin generation plasma from LC...
Bariatric surgery induces several micronutrient deficiencies that require supplementation. For iron, parenteral infusions are usually preferred over oral Ferric carboxymaltose infusion has been associated with hypophosphataemia, mostly transient and asymptomatic. However, in some cases, ferric carboxymaltose-induced hypophosphataemia may persist for weeks to months induce muscle weakness, osteomalacia bone fractures. The aim of this study was identify possible predictors a clinically...
Introduction At the site of vascular injury, by combined activation COllagen And Thrombin (COAT), a fraction platelets lose their aggregating properties and become procoagulant enhancing local thrombin generation fibrin deposition. Decreased or enhanced platelet lead to bleeding thrombotic events, respectively. The intracellular signalling underlying this dichotomous is only partially described. Here, we investigated whether time-lapse phosphoproteomic analysis could identify key regulators...
use in subjects.