A5020726409- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
- Cell Adhesion Molecules Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemostasis and retained surgical items
- Monoclonal and Polyclonal Antibodies Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- Autoimmune Bullous Skin Diseases
- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Iron Metabolism and Disorders
- Renal Diseases and Glomerulopathies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Polyomavirus and related diseases
- Childhood Cancer Survivors' Quality of Life
Children's Hospital of Orange County
2015-2024
Center for Inherited Blood Disorders
2015-2024
University of California, Los Angeles
2024
University of California, Irvine
2014-2023
UC Irvine Health
2016
Fred Hutch Cancer Center
1986-2015
Boston Children's Hospital
2010-2013
University of North Carolina at Chapel Hill
2013
University of California, Irvine Medical Center
2012
Scripps Research Institute
1994-2011
Effective ways to prevent arthropathy in severe hemophilia are unknown.We randomly assigned young boys with A regular infusions of recombinant factor VIII (prophylaxis) or an enhanced episodic infusion schedule at least three doses totaling a minimum 80 IU per kilogram body weight the time joint hemorrhage. The primary outcome was incidence bone cartilage damage as detected index joints (ankles, knees, and elbows) by radiography magnetic resonance imaging (MRI).Sixty-five younger than 30...
The Hemophilia Joint Health Score (HJHS) was developed and validated to detect arthropathy in children. Additional evidence is required show validity adults. We studied the convergent discriminant construct of HJHS version 2.1(HJHSv2.1) adults with hemophilia. A secondary aim define age-related normative adult HJHSv2.1 reference values.
A monoclonal antibody, PlH5, to the human fibroblast class I1 extracellular matrix receptor (ECMR 11) specifically inhibits adhesion collagen and immunoprecipitates a cell surface containing an 8 subunit of approximately 140 kilodaltons each (Wayner, E. A., Carter, W. G .(1987
Lack of detailed natural history and outcomes data for neonates toddlers with haemophilia hampers the provision optimal management disorder. We report an analysis prospective collected from 580 aged 0-2 years enrolled in Universal Data Collection (UDC) surveillance project Centers Disease Control Prevention (CDC). This study focuses on a cohort babies whose diagnosis was established before age two. The mode delivery, type severity haemophilia, onset timing haemorrhages, site(s) bleeding,...
Laboratory evaluation of bleeding disorders has been performed with the standard clotting assays such as PT and PTT for several decades. Our improved understanding process blood coagulation now revealed important role played by cellular elements platelets, monocytes red cells. The need a test that can assess in more 'global' manner, beyond initiation clot formation, led to greater interest thrombin generation thromboelastography. Even though there are publications using thromboelastography...
Severe hemophilia and subsequent hemophilic arthropathy result in joint pain impaired health-related quality of life (HRQoL). Assessment HRQoL persons with (PWH), including underlying factors that drive differences, is important determining health care resource allocation making individualized clinical decisions.To examine potential associations between HRQoL, interference, self-reported arthritis age, employment, activity, bleed frequency, treatment center professional utilization.PWH (age...
Sickle cell disease (SCD) is the most common inherited blood disorder in United States. It a medically and socially complex, multisystem illness that affects individuals throughout lifespan. Given improvements care, children with SCD survive into adulthood. However, access to adult sickle care poor many parts of States, resulting increased acute utilization, disjointed delivery, early mortality for patients. A dearth nonmalignant hematology providers, lack national registry, absence...
Soluble fibronectin binds specifically to glycoprotein (GP) IIb-IIIa on thrombin-activated platelets, and this binding is not observed with platelets of patients Glanzmann's thrombasthenia (GT) which lack GPIIb-IIIa. Here we report that GT retain the ability interact fibronectin-coated surfaces. Adhesion does require platelet activation inhibited by soluble fibronectin, antibodies specific for peptides containing sequence Arg-Gly-Asp polyclonal band 3 chicken embryo fibroblast receptor...
Neonatal alloimmune thrombocytopenic purpura associated with a new platelet-specific alloantigen Pena has been reported. We now provide direct evidence that the determinant is glycoprotein (GP) IIIa, but it distinct from epitopes define PlA system. By ELISA wherein monoclonal antibodies specific for GPIIb (Tab) and GPIIIa (AP3) were used to capture hold antigens platelet lysate prepared under conditions generate free GPIIIa, anti-Pena reacted held by AP3 not Tab. In an alternative where...