A5041108810- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood groups and transfusion
- Pregnancy and preeclampsia studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antiplatelet Therapy and Cardiovascular Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Maternal and fetal healthcare
- Birth, Development, and Health
- Vitamin K Research Studies
- Complement system in diseases
- Blood disorders and treatments
- Chronic Myeloid Leukemia Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Eosinophilic Esophagitis
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS oral health manifestations
- Spinal Hematomas and Complications
- Intramuscular injections and effects
University of Milan
2007-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014-2023
Institute of Oncology Research
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2020
Ospedale Maggiore
1999-2020
Ospedale L. Bonomo
2004-2011
Northwestern University
2007
Fırat University
2007
The Royal Free Hospital
2007
University College London
2007
Platelet-activating anti-platelet factor 4 (PF4)/heparin antibodies and anti-PF4 cause heparin-induced thrombocytopenia (HIT) vaccine-induced immune thrombosis (VITT), respectively. Diagnostic treatment considerations differ somewhat between HIT VITT. We identified patients with without proximate heparin exposure or adenovirus-based vaccination who tested strongly positive by PF4/polyanion enzyme-immunoassays negative/weakly platelet activation (HIPA) test but PF4-induced (PIPA) (ie,...
In some uncontrolled studies, a high prevalence of Helicobacter pylori infection unexpectedly has been found in patients with colorectal cancer. The purpose the study was to investigate H. colonic polyps or We reviewed 50 consecutive either adenomas cancer who entered preliminary case-control study. For each patient, 2 age- and gender-matched control subjects were selected (72 males; mean age, 63.1 years). A further 44 (30 14 cancer) subsequently enrolled. compared that subjects. Anti-H....
Enhanced von Willebrand factor (VWF) clearance from plasma is associated with disease (VWD). However, the genetic background of this mechanism not well defined.To determine VWF variants that are reduced survival.Two hundred fifty-four patients VWD (type 1 = 50 and type 2 204) were investigated, results compared 120 healthy controls. The comprehensively characterized for phenotypic features. ratio propeptide (VWFpp)/VWF antigen (VWFpp ratio) was used to establish in each patient state.Out 92...
Hypercoagulability is a risk factor for venous thromboembolism (VTE). Thrombin generation (TG) global coagulation assay that measures an individual's clotting tendency. We hypothesise slow-onset TG (achieved by using low procoagulant stimulus or inhibitor of coagulation) the optimal responsive method detecting hypercoagulability.This study aimed to compare different conditions with respect VTE and assess first VTE. Basal at tissue (TF) concentration high TF in presence absence activated...
Inflammatory bowel diseases are characterized by disorders of immunity, thrombosis large vessels, and microthrombosis mucosal vessels. The expression endothelial protein C receptor (EPCR) thrombomodulin-two receptors the pathway involved in thrombin scavenging inflammation-was studied intestinal resection specimens or biopsies from patients with inflammatory disease controls. soluble forms plasma were measured.This study two university hospitals. After surgery biopsy, tissue samples either...
Abstract Autoantibodies toward clotting factors may develop in people suffering from autoimmune or neoplastic diseases, after drug intake even subjects without apparent conditions. They are more commonly directed against factor VIII (FVIII) von Willebrand leading to acquired hemophilia A syndrome, respectively. Rarely, autoantibodies other factors, such as fibrinogen, FII, FV, FVII, FX, FXI, and FXIII. The clinical picture of an bleeding disorder includes a wide spectrum manifestations...
von Willebrand disease (VWD) type 2 is caused by qualitative abnormalities of factor (VWF). This study aimed to determine the genotypic and phenotypic characterizations a large VWD cohort from Milan. We included 321 patients (54% female) within 148 unrelated families 1995 2021. Patients were fully characterized using laboratory tests, diagnosis was confirmed target genetic analysis Sanger sequencing. diagnosed with 2A (n = 98; 48 families), 2B 85; 38 2M 112; 50 or 2N 26; 12 families)....
Type 3 von Willebrand disease (VWD) is the most severe form of this owing to almost complete deficiency factor (VWF). Replacement therapy with plasma-derived products containing VWF or recombinant rarely cause development alloantibodies against that may be accompanied by anaphylactic reactions.
Summary EPCR is a type I transmembrane protein, highly expressed on the endothelium of large vessels, that binds protein C and augments its activation. In this study, 23bp insertion in gene was found 4/198 survivors myocardial infarction 3/194 patients with deep vein thrombosis. The predicts lacks part extracellular domain, domain cytoplasmic tail. Expression studies showed truncated not localized cell surface, cannot be secreted culture medium, does bind activated C. Since activation...
The Protein S Italian Team (PROSIT) enrolled 79 protein (PS) deficient families and found 38 PROS1 variations (19 novel) in 53 probands. Of these, 23 variants were selected for expression in'vitro, to evaluate their role as possible causative variants. Transient showed high secretion levels (>75%) three variants, which considered neutral. Seven missense five nonsense low (≤11%) classified severe defects. Intermediate was observed eight evaluated by factor Va inactivation assay order be...
Summary Patients with von Willebrand disease ( VWD ) may need orthopaedic surgery because of disabling chronic arthropathy due to recurrent joint bleeding. They also require this independently their haemostasis disorder. Knowledge regarding the management in is limited. Description patients , based upon retrospective data collection and analysis 32 procedures carried out over a period 33 years 23 was aim study. Of procedures, six were minor (three hand surgery, one foot two others) 26 major...
Late fetal loss can be associated with placental insufficiency and coagulation defects. Thrombomodulin (TM) the endothelial protein C receptor (EPCR) are glycoprotein receptors expressed mainly on surface of blood vessels also in placenta; they both play a key physiological role anticoagulant pathway. Defects these proteins might an important pathogenesis late loss. We performed case–control study 95 women unexplained (> 20 weeks), to elucidate whether TM or EPCR gene mutations were...