A5049681466- Platelet Disorders and Treatments
- Genetic and phenotypic traits in livestock
- Blood groups and transfusion
- Hemophilia Treatment and Research
- Blood disorders and treatments
- Veterinary Equine Medical Research
- Chronic Myeloid Leukemia Treatments
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Animal Nutrition and Physiology
- Chronic Lymphocytic Leukemia Research
- Genetic diversity and population structure
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Animal Genetics and Reproduction
- Parasite Biology and Host Interactions
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Agriculture and Biological Studies
- Monoclonal and Polyclonal Antibodies Research
- Genetic Mapping and Diversity in Plants and Animals
- Invertebrate Taxonomy and Ecology
- melanin and skin pigmentation
Semmelweis University
2006-2025
Emory University
2015-2024
Winship Cancer Institute
2018-2020
Piedmont Cancer Institute
2020
Unified Szent István and Szent László Hospital
2003-2018
Kinshasa General Hospital
2016
University of Würzburg
2016
St.Petersburg V.M.Bekhterev Psychoneurological Research Institute
2016
Bernhard Nocht Institute for Tropical Medicine
2016
University of Tübingen
2016
von Willebrand factor (VWF) is a multimeric glycoprotein that required for normal hemostasis. After translocation into the endoplasmic reticulum, proVWF subunits dimerize through disulfide bonds between their C-terminal cystine knot-like (CK) domains. CK domains are characterized by six conserved cysteines. Disulfide cysteines 2 and 5 3 6 define ring penetrated bond 1 4. Dimerization often mediated additional differ among domain subfamilies. When expressed in baculovirus system, recombinant...
Acquired hemophilia A (AHA) is a rare severe autoimmune bleeding disorder with significant morbidity and mortality. Although critical for disease control, there no consensus the best immunosuppressive regimen. Most authors use steroids first line, followed by other agents steroid failures. Upfront combined regimens offer advantage of reduced exposure toxicity as well increased efficacy. We retrospectively analyzed data from 32 patients AHA treated on an identical such institutional protocol:...
Summary Blood samples of 561 Lipizzan horses from subpopulations (studs) seven European countries representing a large fraction the breed's population were used to examine genetic diversity, subdivision and gene flow in breed. DNA analysis based on 18 microsatellite loci revealed that diversity (observed heterozygosity = 0.663, 0.675 mean number alleles 7.056) horse is similar other breeds as well domestic animal species. The differentiation between different studs, although moderate, was...
Introduction Acquired Hemophilia A (AHA) is a rare autoimmune disorder characterized by the emergence of inhibitors that specifically target coagulation Factor VIII, frequently resulting in severe bleeding episodes. Methods We conducted retrospective analysis medical records 68-year-old male patient who presented with adalimumab-induced AHA. Results The received adalimumab, tumor necrosis factor inhibitor antibody, as part his treatment for rheumatoid arthritis. patient’s clinical journey,...
Abstract Type 3 von Willebrand disease (VWD3) is a rare and severe bleeding disorder characterized by often undetectable factor (VWF) plasma levels, recessive inheritance pattern, heterogeneous genotype. The objective of this study was to identify the VWF defects in 265 European Iranian patients with VWD3 enrolled 3WINTERS-IPS (Type Von International Registries Inhibitor Prospective Study). All analyses were performed centralized laboratories. genotype studied 231 available DNA (121 [115...
Type 3 von Willebrand disease (VWD) is the most severe form of this owing to almost complete deficiency factor (VWF). Replacement therapy with plasma-derived products containing VWF or recombinant rarely cause development alloantibodies against that may be accompanied by anaphylactic reactions.
Abstract In a previous paper, comprehensive clinicopathologic approach to mild and moderate bleeding disorders (MBD) was proposed by an international working group (IWG) as part of project promoted the European Hematology Association (EHA) on development guidelines various MBDs. A single pre‐diagnosis grade 4 event according ISTH‐BAT scale or comparable after diagnosis considered sufficient classify patient affected severe disorder (SBD). this article, original IWG integrated experts...
The long-term survival of donor lymphoid cells in recipients solid-organ transplants or fetal lymphocytes that cross the placenta and enter maternal circulation has been established,1–3 but fate other hematopoietic progenitors organ allografts, especially those myeloid lineage, is not known. We describe a case which acute promyelocytic leukemia developed recipient liver transplant two years after transplantation. leukemic clone had genetic phenotypic markers donor, previously healthy...
Summary To investigate whether allergen‐specific IgE production is influenced by environmental and genetic factors, levels against 2 mould extracts ( Alternaria alternata [Alt a] Aspergillus fumigatus [Asp f]) recombinant (r) rAlt a 1, rAsp f 7 8 were determined ELISA in sera from 448 Lipizzan horses living 6 studfarms. Statistical evaluation showed significant effect of studfarm‐specific environment on the different allergens, but factors also production: an heritability 0.33 was found for...
Ocular pentastomiasis is a rare infection caused by the larval stage of pentastomids, an unusual group crustacean-related parasites. Zoonotic pentastomids have distinct geographical distribution and utilize reptiles or canids as final hosts. Recently, increasing number human abdominal infections been reported in Africa, where emerging, though severely neglected, tropical disease. Here we describe four ocular from Democratic Republic Congo. Two cases underwent surgery Armillifer grandis was...
Snakeborne Armillifer pentastomiasis is an emerging human parasitic infection in rural tropical areas where snake meat eaten. After a series of severe ocular A. grandis larval infections and anecdotal abdominal Sankuru District, Democratic Republic the Congo, during 2014-2015, we systematically investigated possible pentastomid etiology patients who underwent surgery region. Histologic molecular analyses by established 18S rDNA- newly developed Armillifer-specific cytochrome oxidase PCRs...