A5055869476- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Blood groups and transfusion
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heparin-Induced Thrombocytopenia and Thrombosis
- Autoimmune Bullous Skin Diseases
- Alcohol Consumption and Health Effects
- Blood disorders and treatments
- Pharmacology and Obesity Treatment
- Renal Diseases and Glomerulopathies
- Forensic Toxicology and Drug Analysis
- Lipoproteins and Cardiovascular Health
- Folate and B Vitamins Research
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Blood transfusion and management
- Lipid metabolism and disorders
- Complement system in diseases
- Hemoglobinopathies and Related Disorders
Pontificia Universidad Católica de Chile
2015-2025
University of Chile
1995-2022
University of Pittsburgh Medical Center
2019
Ospedale San Bortolo
2019
Hemophilia Center of Western Pennsylvania
2019
Hospital Clínico de la Universidad de Chile
1995-2010
Leitat Technological Center
2007
Hospital Clínico de la Universidad Católica
1992-1995
Catholic University of America
1984-1992
Fogarty International Center
1982
Background and Objectives Mucocutaneous bleeding (MCB) is the main expression of inherited disorders primary hemostasis. However, relative prevalence these disorders, their clinical differential diagnosis, proportion patients with MCB unknown cause (BUC) after an initial comprehensive laboratory testing are unknown.Design Methods We studied prospectively 280 consecutive 299 matched controls, using strict inclusion exclusion criteria. A single physician recorded data in a score estimated...
Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon adhesion to fibrinogen. Full spreading of platelets on fibrinogen was abolished in from VI- deficient patients suggesting activates through VI. While mouse failed spread fibrinogen, human-glycoprotein VI-transgenic showed full increased Ca2+ signaling the tyrosine kinase Syk. Direct...
An increase in circulating platelets, or thrombocytosis, is recognized as an independent risk factor of bad prognosis and metastasis patients with ovarian cancer; however the complex role platelets tumor progression has not been fully elucidated. Platelet activation associated epithelial to mesenchymal transition (EMT), while Tissue Factor (TF) protein expression by cancer cells shown correlate hypercoagulable state metastasis. The aim this work was determine effect platelet-cancer cell...
The risk for thrombosis is significantly increased in systemic lupus erythematosus (SLE), affecting both venous and arterial vessels. Activated platelets are known to participate thrombus formation growth. A general feature of activated cells the shedding microparticles (MP) which support coagulation by exposure negatively charged phospholipids possibly tissue factor (TF). In this work we characterized circulating MP patients with SLE their relationship a procoagulant state. Thirty (aged...
Background The inhibitory effect of adenosine on platelet aggregation is abrogated after the addition adenosine-deaminase. Inosine a naturally occurring nucleoside degraded from adenosine. Objectives mechanisms antiplatelet action and inosine in vitro vivo, their differential biological effects by molecular modeling were investigated. Results Adenosine (0.5, 1 2 mmol/L) inhibited phosphatidylserine exposure 52±4% control group to 44±4 (p<0.05), 29±2 (p<0.01) 20±3% (p<0.001). P-selectin...
Several parameters of primary hemostasis and markers activation coagulation fibrinolysis were measured in 48 patients with severe (creatinine clearance < 20 ml/min) chronic renal failure (CRF) without dialysis disease or drugs affecting hemostasis. Bleeding time (BT) was prolonged 25/48 patients, correlated age severity failure, hematocrit, impairment platelet aggregation-secretion decrease ATP content. Defects von Willebrand factor played no role the prolongation BT. Multivariate analysis...
Abstract Following infusion of 51 Cr‐labeled autologous platelets into normal subjects, high‐density (HD) and low‐density (LD) platelet cohorts were isolated by prolonged centrifugation in isosmotic arabino‐galactan (Stractan). Specific radioactivity LD declined rapidly post‐infusion (T 1/2 = 1.5 days), but specific HD remained constant or increased over a 3–4‐day period gradually for 6–7 days thereafter. These differences exaggerated when enriched cells slow albumin labeled transfused. Mean...
Abstract Objective To evaluate the feasibility of diet mediterranisation, in a food-at-work context, and its consequence on metabolic syndrome mid-age unselected healthy male population group. Design One-year longitudinal intervention study. Physical exercise was not modified. Setting All workers Santiago division ‘Maestranza Diesel’, metal-mechanic company servicing mining industry, were invited to participate. Subjects Initially, 145 total 171, average age 39 years, accepted participate...
Abstract Congenital mild bleeding disorders (MBDs) are very prevalent and the source of frequent diagnostic problems. Most MBDs categorized as primary hemostasis (ie, type 1 VWD platelet function disorders), but or moderate deficiencies clotting factors some rare hyperfibrinolytic also included. These patients have abnormal from skin mucous membranes, menorrhagia, disproportionate hemorrhages after trauma, invasive procedures, surgery. This review addresses main problems that physicians...