A5079075203- Antiplatelet Therapy and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Protease and Inhibitor Mechanisms
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Sirtuins and Resveratrol in Medicine
- Esophageal Cancer Research and Treatment
- Lipoproteins and Cardiovascular Health
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Blood groups and transfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Pulmonary Hypertension Research and Treatments
- Cell Adhesion Molecules Research
- HIV-related health complications and treatments
- Pain Management and Treatment
- Inflammatory mediators and NSAID effects
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Esophageal and GI Pathology
University of Perugia
2015-2025
University of Bari Aldo Moro
2021
Istituto Nazionale Biostrutture e Biosistemi
2020
University of Chieti-Pescara
2007
Severe acute respiratory syndrome coronavirus 2 infection is associated with hypercoagulability, which predisposes to venous thromboembolism (VTE). We analyzed platelet and neutrophil activation in patients disease 2019 (COVID-19) their association VTE.Hospitalized COVID-19 age- sex-matched healthy controls were studied. Platelet leukocyte activation, extracellular traps (NETs), matrix metalloproteinase 9, a neutrophil-released enzyme, measured. Four restudied after recovery. The activating...
Ischemic cardiovascular events increasingly occur during long-lasting HIV infection and are attributed either to the itself or use of HAART. Endothelial dysfunction platelet activation markers atherosclerosis. Our aim was assess whether patients with chronic present endothelial this is consequence HAART.Fifty-six HIV-infected were studied in a retrospective cohort study before 3, 6, 12 24 months after starting HAART protease inhibitors (n = 28) nonnucleoside reverse transcriptase 28),...
Summary Abacavir (ABC) has been associated with ischaemic cardiovascular events in HIV-infected patients, but the pathogenic mechanisms are unknown. Aim of our study was to assess whether ABC induces vivo platelet activation and ex hyper-reactivity. In a retrospective, case-control study, markers were measured 69 before starting therapy after 6–12 months either (n=35) or tenofovir (TDF) (n=34), compared those from 20 untreated patients. A subgroup patients restudied 28–34 for reactivity....
Background and Objectives A high incidence of atherosclerotic lesions cardiovascular events has been reported in patients with spontaneous venous thromboembolism. Endothelial dysfunction is an early marker atherosclerosis predictive value for ischemic events. We have evaluated endothelial function a history thromboembolism.Design Methods Patients symptomatic, objectively confirmed, thromboembolism were included case-control study. Exclusion criteria any known risk factors diseases, other...
To investigate whether selected matrix metalloproteinases (MMPs) are released in the coronary circulation of patients with acute syndrome (ACS), this release is related to platelet activation, and it contributes sustained activation.Blood from aorta (Ao) sinus (Cs) was obtained 21 controls (non-cardiac chest pain), 24 stable angina (SA), 30 ACS patients, before performing percutaneous transluminal angioplasty. Selected MMPs, some activation- atheroma-related markers, activation-potentiating...
Summary Platelets contain, besides α- and δ-granules, lysosomes which store glycohydrolases able to degrade glycoproteins, glycolipids glycosaminoglycans. While several studies have shown that δ-granule secretion takes place “in vivo” in humans upon platelet activation, no data are available on the release of lysosomes. We studied lysosomal contents healthy volunteers at a localized site activation by measuring markers blood oozing from skin wound inflicted for measurement bleeding-time. The...
Background Defects of integrin αIIbβ3 are typical Glanzmann's thrombasthenia, an inherited autosomal recessive bleeding disorder characterized by the failure platelets to aggregate in response all physiological agonists, but with no abnormalities number or size platelets. Although large heterogeneity has been described for family so far as having dominant form this disease.Design and Methods We describe two Italian families moderate thrombocytopenia platelets, defective platelet function...
OBJECTIVE Acute, short-term hyperglycemia enhances high shear stress–induced platelet activation in type 2 diabetes. Several observations suggest that platelets diabetes are resistant to inhibition by aspirin. Our aim was assess comparatively the effect of aspirin, a nitric oxide–donating agent (NCX 4016), their combination, or placebo on induced acute RESEARCH DESIGN AND METHODS In double-blind, placebo-controlled, randomized trial, 40 diabetic patients were allocated 100 mg aspirin once...
Metabolic Syndrome (MS) is characterized by a low-grade inflammatory state causing an alteration of non-invasive indexes derived from blood count, namely monocyte-to-HDL ratio (MHR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR). We analyse population 771 subjects (394 controls and 377 MS patients) to evaluate the best predictive index MS. The diagnosis was made according 2006 criteria International Diabetes Federation (IDF). performed ROC curve...
The effectiveness of vaccination against SARS-CoV-2 in preventing COVID-19 or reducing severe illness subjects hospitalized for despite has been unequivocally shown. However, no studies so far have assessed if who get are protected from SARS-CoV-2-induced platelet, neutrophil and endothelial activation, biomarkers associated with thrombosis worse outcome. In this pilot study, we show that previous blunts COVID-19-associated platelet by circulating platelet-derived microvesicles soluble...
Background The assessment of clinical prognosis in autoimmune encephalitis: Girona (ACPE-Gi) score is a scale for evaluating the severity acute phase encephalitis (AE) and predicting risk disability at 3 months, measured by modified Rankin (mRS). Methods Patients were strictly diagnosed with AE according to current criteria between 1 January 2009 31 March 2023 University Hospital Dr. Josep Trueta Girona, Catalonia, Spain. ACPE-Gi included 14 items, every item was scored from 0 3, depending...
Oxidative stress has been associated with COVID-19-related thrombotic complications. No investigations have explored nitric oxide (NO) and radical oxygen species (ROS) production by platelets. Indeed, activated platelets generate both NO ROS which in turn regulate platelet function. The aim of the present study was to measure COVID-19 patients, assess whether they correlate disease outcome clarify mechanisms NO/ROS imbalance COVID-19.Hospitalized mild severe age- sex-matched healthy...