A5056370325- Chemical Synthesis and Reactions
- Plant chemical constituents analysis
- Cyclopropane Reaction Mechanisms
- Multicomponent Synthesis of Heterocycles
- Oxidative Organic Chemistry Reactions
- Phytochemistry and Biological Activities
- Synthetic Organic Chemistry Methods
- Natural product bioactivities and synthesis
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Synthesis and Biological Evaluation
- Sulfur-Based Synthesis Techniques
- Essential Oils and Antimicrobial Activity
- Synthesis of Organic Compounds
- Chemical Synthesis and Characterization
- Organic Chemistry Cycloaddition Reactions
- Sesquiterpenes and Asteraceae Studies
- Inorganic and Organometallic Chemistry
- Organoselenium and organotellurium chemistry
- Chemical synthesis and alkaloids
- Synthesis and Reactions of Organic Compounds
- Bioactive Compounds and Antitumor Agents
University of Perugia
2011-2020
University of Chieti-Pescara
2007-2012
Magna Graecia University
2011
Istituto Neurologico Mediterraneo
2008
University of Naples Federico II
2006
University of Turin
2006
University of Trieste
2002
GTx (United States)
2000
Università di Camerino
1998-1999
Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway that meets structural requirements to interact with glutamate receptors. We found cinnabarinic acts as a partial agonist type 4 metabotropic (mGlu4) receptors, no activity at other mGlu receptor subtypes. also tested on native mGlu4 receptors by examining 1) inhibition cAMP formation in cultured cerebellar granule cells; 2) protection against excitotoxic neuronal death mixed cultures cortical and 3)...
A mild, practical, and simple procedure for phenyl selenoesters synthesis from several anhydrides diphenyl diselenide was developed. This transition-metal-free method provides a straightforward entry to storable Fmoc-amino acid which are effective chemoselective acylating reagents. An application oligopeptide illustrated.
Dithioacetals from disulfides<italic>via</italic>homologation.
Differently substituted benzimidazoles have been synthesised in very good yields solvent-free conditions from o-phenylenediamine and aldehydes the presence of Yb(OTf)3 as catalyst. The method is applicable to aromatic, unsaturated aliphatic o-phenylenediamines without significant differences.
Abstract We previously reported the chemopreventive ability of a prenyloxycoumarin auraptene in chemically induced carcinogenesis digestive tract, liver and urinary bladder rodents. The current study was designed to determine whether dietary feeding its related collinin can inhibit colitis‐related mouse colon carcinogenesis. experimental diets, containing compounds at 2 dose levels (0.01 0.05%), were fed for 17 weeks male CD‐1 (ICR) mice that initiated with single intraperitoneal injection...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopentanone synthesis by intramolecular carbon-hydrogen insertion of diazo ketones. A diterpene-to-steroid skeleton conversionErnest Wenkert, Linda L. Davis, Banavara Mylari, Mary F. Solomon, Roberto R. Da Silva, Sol Shulman, Ronald J. Warnet, Paolo Ceccherelli, Massimo Curini, and PellicciariCite this: Org. Chem. 1982, 47, 17, 3242–3247Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1...
Abstract The inhibitory effects of novel prodrugs, inclusion complexes 3‐(4′‐geranyloxy‐3′‐methoxyphenyl)‐2‐ trans propenoic acid (GOFA) and auraptene (AUR) with β‐cyclodextrin (CD), on colon carcinogenesis were investigated using an azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Male CD‐1 (ICR) mice initiated a single intraperitoneal injection AOM (10 mg/kg body weight) promoted by the addition 1.5% (w/v) DSS to their drinking water for 7 days. They then given basal diet containing...
Abstract Layered zirconium sulfophenyl phosphonate was found to be an efficient heterogeneous catalyst for the trimethylsilylation of alcohols and phenols.
Collinin (1), a geranyloxycoumarin, has been synthesized in three steps and 24.6% overall yield from pyrogallol (2) propiolic acid (3).
The choice of layered phosphates and phosphonates tetravalent metals, mainly Zr(IV), plays a key role in the success liquid phase heterogeneous catalysis for preparation useful intermediates organic synthesis. preparation, chemical thermal stability, structural aspects this emerging class inorganic inorgano-organic materials will be reviewed with aim to clarify their potential catalysis. possibility modifying surface area porosity nature active catalytic centres by means ion exchange,...
Auraptene is a prenyloxycoumarin from <i>Citrus</i> species with chemopreventive properties against colitis-related colon and breast cancers through yet-undefined mechanism. To decipher its mechanism of action, we used ligand-structure based approach. We established that auraptene fits pharmacophore involved in both the inhibition acyl-CoA:cholesterol acyl transferase (ACAT) modulation estrogen receptors (ERs). confirmed experimentally inhibits ACAT binds to ERs concentration-dependent...
Erbium(III) chloride in ethyl lactate is used as an environmentally very friendly system for the reaction of furfural and amines to yield diastereoselectively differently N,N-substituted trans-4,5-diaminocyclopent-2-enones versatile synthetic intermediates formation densely functionalized derivatives.