A5015038759- Chemical Synthesis and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Click Chemistry and Applications
- Microwave-Assisted Synthesis and Applications
- Nanomaterials for catalytic reactions
- Drug Solubulity and Delivery Systems
- Chemical Synthesis and Reactions
- Asymmetric Hydrogenation and Catalysis
- Nanoparticle-Based Drug Delivery
- Synthesis and Biological Evaluation
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Chromatography
- Multicomponent Synthesis of Heterocycles
- Crystallization and Solubility Studies
- Inorganic and Organometallic Chemistry
- Crystallography and molecular interactions
- Catalytic Cross-Coupling Reactions
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Synthesis and biological activity
- Ultrasound and Cavitation Phenomena
- Enzyme Catalysis and Immobilization
- Molecular Junctions and Nanostructures
- Zeolite Catalysis and Synthesis
- Fuel Cells and Related Materials
University of Turin
2015-2024
Istituto di Farmacologia Traslazionale
2014-2017
Interface (United States)
2014-2017
Torino e-district
2014-2016
Nerviano Medical Sciences
2003-2010
Universidad de Alcalá
2010
GlaxoSmithKline (Italy)
2007-2008
Ollscoil na Gaillimhe – University of Galway
2007-2008
Max Planck Society
1998
Max Planck Institute for Polymer Research
1998
The impressive pharmacological properties shown by a number of coumarins have led to extraordinarily large emphasis being placed on the design more efficient and greener synthetic procedures produce them.
Microwave-assisted organic synthesis has been widely studied and deliberated, opening up some controversial issues as well. Nowadays, microwave chemistry is a mature technology that well demonstrated in many cases with numerous advantages terms of the reaction rate yield. The strategies toward scaling find an ally continuous-flow reactor comparing dielectric conductive heating.
Abnormal proliferation mediated by disruption of the normal cell cycle mechanisms is a hallmark virtually all cancer cells. Compounds targeting complexes between cyclin-dependent kinases (CDK) and cyclins, such as CDK2/cyclin A E, inhibiting their kinase activity are regarded promising antitumor agents to complement existing therapies. From high-throughput screening effort, we identified new class A/E inhibitors. The hit-to-lead expansion this described. X-ray crystallographic data early...
The syntheses of almost all N-heterocycles have now been successfully performed under microwave irradiation and provided significant improvements in the reaction time efficiency. peculiar properties dielectric heating give it ability to strongly promote cyclocondensation, cycloaddition selective N-heterocycle functionalisation has, therefore, very much caught attention medicinal chemistry community. In this work, we present an overview recent literature technical advances research field with...
Glioblastoma is the most common and invasive primary tumor of central nervous system normally has a negative prognosis. Biodistribution in healthy animal models an important preliminary study aimed at investigating efficacy chemotherapy, as it mainly addressed towards residual cells after surgery region with intact blood–brain barrier. Nanoparticles have emerged versatile vectors that can overcome In this experimental work, solid lipid nanoparticles, prepared using fatty acid coacervation,...
Cdc7 kinase is an essential protein that promotes DNA replication in eukaryotic organisms. Genetic evidence indicates inhibition can cause selective tumor-cell death a p53-independent manner, supporting the rationale for developing small-molecule inhibitors treatment of cancers. In this paper, synthesis and structure-activity relationships 2-heteroaryl-pyrrolopyridinones, first potent inhibitors, are described. Starting from 2-pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one,...
Abstract The massive increase in glycerol production from the transesterification of vegetable oils has stimulated a large effort to find novel uses for this compound. Hence, use as solvent organic synthesis drawn particular interest. Drawbacks green and renewable are low solubility highly hydrophobic molecules high viscosity, which often requires fluidifying co‐solvent. These limitations can be easily overcome by performing reactions under high‐intensity ultrasound microwaves stand‐alone or...
The ball-mill-based mechanochemical activation of metallic copper powder facilitates solvent-free alkyne-azide click reactions (CuAAC). All parameters that affect reaction rate (i.e., milling time, revolutions/min, size and ball number) have been optimized. This new, efficient, facile eco-friendly procedure has tested on a number different substrates in all cases afforded the corresponding 1,4-disubstituted 1,2,3-triazole derivatives high yields purities. final compounds were isolated almost...
Aims: Advanced melanoma is characterized by poor outcome. Despite the number of treatments having been increased over last decade, current pharmacological strategies are only partially effective. Therefore, improvement systemic therapy worthy investigation. Methods: a nanotechnology-based poly-chemotherapy was tested at preclinical level. Temozolomide, rapamycin, and bevacizumab were co-loaded as injectable nanoemulsions for total parenteral nutrition (Intralipid®), due to suitable devices,...
Cdc7 kinase is a key regulator of the S-phase cell cycle, known to promote activation DNA replication origins in eukaryotic organisms. inhibition can cause tumor-cell death p53-independent manner, supporting rationale for developing inhibitors treatment cancer. In this paper, we conclude structure-activity relationships study 2-heteroaryl-pyrrolopyridinone class compounds that display potent inhibitory activity against kinase. Furthermore, also describe discovery 89S,...
Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. inhibition through siRNA or prototype small molecules causes p53 independent apoptosis tumor cells while reversibly arresting cell cycle progression primary fibroblasts. This implies that could be considered potential target for anticancer therapy. We previously reported pyrrolopyridinones (e.g., 1) are potent and selective inhibitors kinase, with good cellular potency vitro ADME properties but...
The hydroxytriazole system is here analysed and used to modulate acidic moieties present in lead compounds.
A fast and efficient protocol for the synthesis of N,N'-disubstituted urea derivatives from alkyl halides primary or secondary amines has been developed. The synthetic pathway combines nucleophilic substitutions a Staudinger-aza-Wittig reaction in presence polymer-bound diphenylphosphine under 14 bar CO2 pressure performed one-pot two-step process. optimized microwave irradiation scale-up experiment conducted conventional conditions Parr reactor. final compounds were isolated after simple...
Mechanochemical “parallel synthesis”: processing 12 samples simultaneously allowed fast screening of the optimum reaction conditions and high throughput preparation benzozaxine derivatives, including a fungicide.
The C2 amination of benzoxazole offers wide-ranging potential for substrate expansion and the functionalisation bioactive compounds. This study presents a green efficient C-H amination, catalysed by CuCl CuCl₂, in acetonitrile without acidic, basic or oxidant additives that is accelerated Microwave (MW) irradiation completed 1.5–2 h. A solid Cu(I) catalyst supported on aminated silica made process cost-effective heterogeneous, thus simplifying work-up minimising free copper solution. was...
Bridged cyclodextrin dimers and trimers, in which respectively two three hydrophobic cavities lie close proximity, display much higher binding affinities molecular selectivities than do parent cyclodextrins (CDs). By joining βCD units with links inserted at different positions (2-2′, 3-2′, 6-2′ or 6-2′-6″) interposing spacers of lengths shapes, multicavity structures can be synthesized that are precisely tailored to fit specific guest molecules. This enzyme-mimicking strategy also used...
Nowadays the application of cyclodextrin-assisted molecular encapsulation in foods offers many advantages. Cyclodextrins, their derivatives and cross-linked polymers can all improve quality food storage, remove specific components stabilize increase presence that are important for a healthy diet. The cyclodextrins complexes packaging materials help not only transport previously nontransportable foods, but may also prevent, or at least decelerate, spread microbial infections. Keywords:...
Eco-compatible activation methods in Suzuki–Miyaura cross-coupling reactions offer challenging opportunities for the design of clean and efficient synthetic processes. The main enabling technologies described literature are microwaves, ultrasound, grinding (mechanochemistry) light. These can be performed water or other green solvents with phase-transfer catalysis even solventless conditions. In this review, authors will summarize progress field mainly from 2010 up to present day.