A5030584940- Plant chemical constituents analysis
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Phytochemistry and Biological Activities
- Multicomponent Synthesis of Heterocycles
- Phytochemistry and biological activity of medicinal plants
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Bioactive Compounds
- Morinda citrifolia extract uses
- Diet and metabolism studies
- Plant biochemistry and biosynthesis
- Inflammatory mediators and NSAID effects
- Chemical Synthesis and Reactions
- Microwave-Assisted Synthesis and Applications
- Bee Products Chemical Analysis
- Helicobacter pylori-related gastroenterology studies
- Fungal Biology and Applications
- Synthesis of Indole Derivatives
- Chromatography in Natural Products
- Diet, Metabolism, and Disease
University of Chieti-Pescara
2016-2025
Istituto Zooprofilattico Sperimentale delle Venezie
2025
University of Messina
2024
Leonardo (Italy)
2022
Istituto di Farmacologia Traslazionale
2020
Nordic Bioscience (Denmark)
2018
Università a Vicenza
2017
University of Naples Federico II
1984-2015
University of Perugia
2005-2011
University of Bologna
2010
OBJECTIVE—To evaluate the accuracy of a new subcutaneous glucose sensor (Glucoday; A. Menarini Diagnostics) compared with venous blood measurement in type 1 and 2 diabetic patients. RESEARCH DESIGN—A multicenter study was performed 70 A microdialysis fiber inserted subcutaneously into periumbelical region perfused buffer solution. Glucose concentrations dialysate were then measured every 3 min by over 24-h period, during which nine samples also collected throughout day. RESULTS—Both...
Abstract The inhibitory effects of novel prodrugs, inclusion complexes 3‐(4′‐geranyloxy‐3′‐methoxyphenyl)‐2‐ trans propenoic acid (GOFA) and auraptene (AUR) with β‐cyclodextrin (CD), on colon carcinogenesis were investigated using an azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Male CD‐1 (ICR) mice initiated a single intraperitoneal injection AOM (10 mg/kg body weight) promoted by the addition 1.5% (w/v) DSS to their drinking water for 7 days. They then given basal diet containing...
Aloe barbadensis Miller (Aloe vera) is a herbal remedy widely used for variety of illnesses; A. vera leaf extracts have been promoted detoxification, cure constipation, help flush out toxins and wastes from the body, promote digestion are in treatment peptic ulcer cytoprotective action. The aim this study was to evaluate antibacterial activity inner gel against both susceptible resistant Helicobacter pylori strains isolated Abruzzo region, Italy. leaves 5-year-old plant extracted,...
Several processes have been developed in the past to selectively extract oleuropein and its aglycones from olive derived materials. In present manuscript, we outline a novel approach for processing leaves aqueous extracts. This allowed first select microwave irradiation as methodology able provide large enrichment oleuropein. Subsequently, use of lamellar solids led selective high yield concentration same. Adsorption on also largely contributed long term chemical stability Finally, an...
Abstract Introduction – Rhamnus alpinus L. (Rhamnaceae), a traditional plants in the flora of Abruzzo region, is known to contain active anthraquinone secondary metabolites. However, content anthraquinones varies among R. samples depending on collection season and site. Thus, using simple, reliable accurate analytical methods for determination extracts allows comparative study different extraction. Objective After partial validation an HPLC method simultaneous five anthraquinones,...
Auraptene is a prenyloxycoumarin from <i>Citrus</i> species with chemopreventive properties against colitis-related colon and breast cancers through yet-undefined mechanism. To decipher its mechanism of action, we used ligand-structure based approach. We established that auraptene fits pharmacophore involved in both the inhibition acyl-CoA:cholesterol acyl transferase (ACAT) modulation estrogen receptors (ERs). confirmed experimentally inhibits ACAT binds to ERs concentration-dependent...
In patients with Parkinson’s disease (PD), hyperactivated inflammation in the brain, particularly microglial hyperactivation substantia nigra (SN), is reported to be one of triggers for delayed loss dopaminergic neurons and sequential motor functional impairments. We previously that (1) auraptene (AUR), a natural prenyloxycoumain, suppressed inflammatory responses including microglia ischemic brain inflamed thereby inhibiting neuronal cell death; (2) 7-isopentenyloxycoumarin (7-IP), another...