A5067794169- Platelet Disorders and Treatments
- Complex Network Analysis Techniques
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 detection and testing
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Opinion Dynamics and Social Influence
- Venous Thromboembolism Diagnosis and Management
- Blood transfusion and management
- Gaussian Processes and Bayesian Inference
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Advanced Clustering Algorithms Research
- Cardiac and Coronary Surgery Techniques
- Soil Geostatistics and Mapping
- Advanced Graph Neural Networks
Heinrich Heine University Düsseldorf
2016-2025
Düsseldorf University Hospital
2011-2025
Harvard University Press
2025
Harvard University
2022-2024
Imperial College London
2013-2023
Department of Health and Social Care
2021-2022
University Medical Center
2021
University Hospital and Clinics
2021
Center for HIV and Hepatogastroenterology
2021
UK Health Security Agency
2021
The COVID-19 pandemic has put unprecedented pressure on public health resources around the world. From adversity, opportunities have arisen to measure state and dynamics of human disease at a scale not seen before. In United Kingdom, evidence that wastewater could be used monitor SARS-CoV-2 virus prompted development National surveillance programmes. pace this work proven unique in monitoring national level, demonstrating importance wastewater-based epidemiology (WBE) for protection. Beyond...
Accurate surveillance of the COVID-19 pandemic can be weakened by under-reporting cases, particularly due to asymptomatic or pre-symptomatic infections, resulting in bias. Quantification SARS-CoV-2 RNA wastewater used infer infection prevalence, but uncertainty sensitivity and considerable variability has meant that accurate measurement remains elusive. Here, we use data from 45 sewage sites England, covering 31% population, estimate prevalence within 1.1% estimates representative surveys...
Rationale: A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated FXa (factor Xa) inhibitors including rivaroxaban compared vitamin K antagonists. At the same time, low-dose shown to reduce mortality and atherothrombotic events coronary artery disease. Yet, mechanisms underlying this reduction remain unknown. Objective: In study, we hypothesized that rivaroxaban’s antithrombotic potential is linked a hitherto unknown effect impacts on platelet...
Platelet-activating anti-platelet factor 4 (PF4)/heparin antibodies and anti-PF4 cause heparin-induced thrombocytopenia (HIT) vaccine-induced immune thrombosis (VITT), respectively. Diagnostic treatment considerations differ somewhat between HIT VITT. We identified patients with without proximate heparin exposure or adenovirus-based vaccination who tested strongly positive by PF4/polyanion enzyme-immunoassays negative/weakly platelet activation (HIPA) test but PF4-induced (PIPA) (ie,...
The traditional way of studying temporal networks is to aggregate the dynamics edges create a static weighted network. This implicitly assumes that are governed by Poisson processes, which not typically case in empirical networks. Consequently, we examine effects non-Poisson inter-event statistics on edges, and apply concept generalized master equation study continuous-time random walks We show reduces standard rate equations when underlying process stationary solution determined an...
We develop a Bayesian hierarchical modelling approach for cosmic shear power spectrum inference, jointly sampling from the posterior distribution of field and its (tomographic) spectra. Inference is powerful intermediate product analysis, since it requires very few model assumptions can be used to perform inference on wide range cosmological models posteriori without loss information. show that joint map sampled effectively by Gibbs sampling, iteratively drawing samples spectrum, each...
Abstract The concentration of SARS-CoV-2 RNA in faeces is not well characterised, posing challenges for quantitative wastewater-based epidemiology (WBE). We developed hierarchical models faecal shedding and fitted them to data from six studies. A mean 1.9 × 106 mL-1 (2.3 105–2.0 108 95% credible interval) was found among unvaccinated inpatients, considering differences between viral variants. Limits quantification could account negative samples based on Bayesian model comparison. Inpatients...
In a single-centre study the feasibility and efficacy of repeated antilymphocyte globulin (ALG) for patients with severe aplastic anaemia (SAA) not responding to an initial ALG treatment or relapsing after response was evaluated. 139 consecutive newly diagnosed SAA were treated between 1976 1995. 89 responded first course; 50 did become transfusion independent. Of responders, 66 remained in remission, 23 relapsed. 43 received second subsequent course failure respond (n = 25) relapse 18)...
Abstract Despite much research on early detection of anomalies from surveillance data, a systematic framework for appropriately acting these signals is lacking. We addressed this gap by formulating hidden Markov-style model time-series surveillance, where the system state, observed and decision rule are all binary. incur delayed cost, c , whenever abnormal no action taken, or an immediate k with action, < . If costs too high, then detrimental, intervention should never occur. sufficiently...
Zusammenfassung Die Anämiebehandlung durch Versorgung mit Eisen, Folsäure und Vitamin B12 Stimulation der Erythropoese Erythropoetin bei Patienten, welche Bluttransfusionen ablehnen, ist eine paradigmatische Herausforderung an das Patient Blood Management (PBM), insbesondere in Notfallsituationen. Je nach Anämieausprägung muss mindestens 14 Tagen für vollständige Anämiekorrektur gerechnet werden. Wir stellen die Dynamik Anämie-Entwicklung -Erholung unter ‚real life‘-Bedingungen verzögertem...
Abstract Background Alcohol intoxication is known to affect blood coagulation. The specific effects remain poorly understood. Here, we investigate the impact of severe alcohol on clotting by comprehensive coagulation testing. Methods A prospective study included 21 patients admitted emergency department University Hospital Düsseldorf with (target concentration > 2 g/l). Platelet function and was compared between states soberness using multiple platelet analysis, thrombelastography...
Background The For Angioedema Subcutaneous Treatment (FAST)-2, a phase III, double-blind, randomized, multicenter, placebo-controlled study (ClinicalTrials.gov identifier: NCT00500656), established the efficacy and safety of single injections icatibant, bradykinin B2 receptor antagonist, in treatment hereditary angioedema (HAE) attacks. Here, we evaluate repeated with icatibant adult patients experiencing HAE attacks during FAST-2 open-label extension (OLE) phase. Methods Patients completing...
Left ventricular assist device (LVAD) pump thrombosis is one of the devastating complications following mechanical circulatory support implantation. Surgical exchange a known high-risk surgery with high perioperative mortality rate. We aim to summarize our experience several other alternative approaches in patients suspected HeartWare HVAD (HeartWare, Framingham, MA, USA) thrombosis.The outcome implantations performed at single institution from January 2010 September 2015 was studied....
We develop a Bayesian hierarchical model to identify communities in networks for which we do not observe the edges directly, but instead series of interdependent signals each nodes. Fitting provides an end-to-end community detection algorithm that does extract information as sequence point estimates propagates uncertainties from raw data labels. Our approach naturally supports multiscale well selection optimal scale using comparison. study properties synthetic and apply it daily returns...
Summary The concentration of SARS-CoV-2 RNA in faeces is not well established, posing challenges for wastewater-based surveillance COVID-19 and risk assessments environmental transmission. We develop versatile hierarchical models faecal shedding apply them to data collected six studies. find that the mean number gene copies per mL 1.9 × 10 6 (2.3 5 –2.0 8 95% credible interval) among unvaccinated hospitalised patients. Using Bayesian model comparison, we no evidence a subpopulation patients...
Earth and Space Science Open Archive This preprint has been submitted to is under consideration at Other. ESSOAr a venue for early communication or feedback before peer review. Data may be preliminary.Learn more about preprints preprintOpen AccessYou are viewing the latest version by default [v1]Wastewater catchment areas in Great BritainAuthorsTillHoffmanniDSarahBunneyBarbaraKasprzyk-HordernAndrewSingeriDSee all authors Till HoffmanniDCorresponding Author• Submitting AuthorImperial College...