A5055029242- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Research on Leishmaniasis Studies
- Urticaria and Related Conditions
- Peptidase Inhibition and Analysis
- Nitric Oxide and Endothelin Effects
- Vitamin K Research Studies
- Trypanosoma species research and implications
- Viral Infections and Vectors
- Hernia repair and management
- Immune Response and Inflammation
- Body Contouring and Surgery
- Eicosanoids and Hypertension Pharmacology
- Vector-borne infectious diseases
- Mast cells and histamine
- Asthma and respiratory diseases
- Wound Healing and Treatments
- Neuropeptides and Animal Physiology
- PI3K/AKT/mTOR signaling in cancer
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Surgical site infection prevention
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- IgG4-Related and Inflammatory Diseases
Ospedale Vincenzo Cervello
2012-2024
Presidio Ospedaliero
2015-2018
University of Palermo
1992-2011
October 6 University
2007
Hereditary angioedema is characterized by recurrent attacks of the skin, larynx, and gastrointestinal tract. Bradykinin key mediator symptoms. Icatibant a selective bradykinin B2 receptor antagonist.
Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE type I) or dysfunction II) is a rare disease characterized by recurrent episodes of edema with an estimated frequency 1:50,000 in the global population without racial gender differences. In this study we present results nationwide survey C1-INH-HAE patients referring 17 Italian centers, network for C1-INH-HAE, ITACA. diagnosed from 1973 2013 were included study. Diagnosis was based on family and/or personal history urticaria...
<h2>Abstract</h2><h3>Background</h3> Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) causes swelling in the skin and upper airways pain abdomen because of mucosal swelling. C1-INH-HAE is frequently misdiagnosed, leading delays diagnosis, inadequate treatment, unnecessary procedures. <h3>Objective</h3> To evaluate history misdiagnosis patients participating Icatibant Outcome Survey (IOS). <h3>Methods</h3> The IOS an observational study which safety effectiveness icatibant...
We have tested whether tetracyclines (TETs) are able to protect mice from lipopolysaccharide (LPS)-induced shock, a cytokine-mediated inflammatory reaction. Mice, injected with single dose of tetracycline base (TETb; 1.5, 10 and 20 mg/kg body weight) or doxycycline (DOXY; 1.5 mg/kg), were significantly protected lethal intraperitoneal injection LPS (500 micrograms per mouse). TETs acted in early events triggered response LSP; fact, they no longer protective if more than 1 h after the...
Background The For Angioedema Subcutaneous Treatment (FAST)-2, a phase III, double-blind, randomized, multicenter, placebo-controlled study (ClinicalTrials.gov identifier: NCT00500656), established the efficacy and safety of single injections icatibant, bradykinin B2 receptor antagonist, in treatment hereditary angioedema (HAE) attacks. Here, we evaluate repeated with icatibant adult patients experiencing HAE attacks during FAST-2 open-label extension (OLE) phase. Methods Patients completing...
ABSTRACT Knowing the dynamics of growth factor and cytokine secretion within site a surgical operation is important, as they play crucial role in pathophysiology wound healing are target for modifying repair response. The aim this study was to evaluate production several cytokines factors drainage fluid from patients undergoing incisional hernia repair: namely, interleukin (IL)‐6, IL‐10, IL‐1α, IL‐1 ra, interferon‐γ, vascular endothelial basic fibroblast factor. Ten female with abdominal...
Introduction Hereditary angioedema due to C1-inhibitor deficiency is influenced by hormonal factors, with a more severe course of disease in women. Our study aims deepen the impact puberty on onset, frequency, location and severity attacks. Methods Retrospective data were collected through semi-structured questionnaire shared 10 Italian reference centers Network for Acquired Angioedema (ITACA). Results The proportion symptomatic patients increased significantly after (98.2% vs 83.9%, p...
To evaluate seroprevalence of B. henselae infection both in Sicilian children and healthy blood donors. Furthermore, circulation Bartonella the natural reservoir was also studied. Two hundred forty-three children, living Sicily (Palermo), affected by various diseases, without clinical features suggesting infection, together with 122 donors were serologically investigated for IgG IgM antibodies indirect fluorescent antibody test (IFAT). One twenty stray 62 pet cats analyzed only IgG. Among...
The macrophage-activating tetrapeptide tuftsin was able to activate, in a dose-dependent manner, murine macrophages express nitric oxide (NO) synthase and produce NO. Tuftsin required lipopolysaccharides for the optimal induction of NO production synergized with gamma interferon synthesis. Tuftsin-dependent sensitive inhibition by dexamethasone specific inhibitor LGN-monomethylarginine (L-NMMA). Murine peritoneal activated were kill amastigotes intracellular protozoan parasite Leishmania major vitro.
The potential leishmanicidal activity of interleukin-15 (IL-15) was examined while priming with the cytokine phorbol-myristate-acetate (PMA)-activated macrophages and infecting them Leishmania infantum parasites. activation macrophage cultures IL-15 determined a significant anti-leishmanial activity, comparable that induced by interferon-gamma (IFN-gamma). killing in primed IL-15, as well IFN-gamma, followed an increase IL-12 synthesis. neutralization or specific monoclonal antibodies (MoAb)...
It was demonstrated that doxycycline protected BALB/c mice injected intraperitoneally with bacterial lipopolysaccharide (LPS) against lethal septic shock. Doxycycline (at 1.5 mg/kg) exerted its protective effect by inhibiting nitrate production an interleukin-10-independent mechanism. Experiments carried out in vitro also indicated inhibited NO synthesis LPSactivated macrophages without inducing any significant modification interleukin-10 release. These data suggest the direct inhibition of...
The aim of the study was to analyze acute inflammatory response after implantation a heavyweight mesh polypropylene (PP) compared with composite light PP and polyglactin 910 (PG) in patients undergoing inguinal hernioplasty. A total 30 male hernia were included divided into 2 groups (PP PP-PG) according used. Changes leukocytes, cytokines, growth factors, phase proteins evaluated sera. Leukocytes significantly increased postoperatively both groups, values slightly higher group. Cytokine...
Introduction In patients with Hereditary Angioedema (HAE) related to primary C1 inhibitor deficiency (C1INH), the defective clearance of immune complexes and apoptotic materials along impairment normal humoral response potentially leads autoimmunity. Few studies report evidence on autoimmune diseases in C1INH-HAE, but no large population focus rare connective tissue (RCTDs). We aim at evaluating for first time prevalence distribution RCTDs - Systemic Lupus Erytematosus (SLE), Sjogren...