A5016222613- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Inflammatory Bowel Disease
- Infant Nutrition and Health
- Immune responses and vaccinations
- Hemophilia Treatment and Research
- Advanced Thermoelectric Materials and Devices
- Thermal Expansion and Ionic Conductivity
- Urticaria and Related Conditions
- Liver Disease Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Heusler alloys: electronic and magnetic properties
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Vitamin K Research Studies
- Adipose Tissue and Metabolism
- Biosimilars and Bioanalytical Methods
- Cardiovascular Disease and Adiposity
- Pharmaceutical studies and practices
- Cancer Immunotherapy and Biomarkers
- Mitochondrial Function and Pathology
- Chronic Myeloid Leukemia Treatments
- Metal and Thin Film Mechanics
- Metabolomics and Mass Spectrometry Studies
First Affiliated Hospital of Hebei Medical University
2015-2024
Hebei Medical University
2015-2024
Hebei General Hospital
2024
Henan University of Science and Technology
2012-2023
Tianjin University
2023
Henan University of Technology
2011-2022
National Clinical Research
2021
Shanghai Research Institute of Sports Science
2021
Affiliated Hospital of Southwest Medical University
2021
Takeda (United States)
2018-2020
Objective To evaluate the interleukin-6 receptor inhibitor tocilizumab for treatment of patients with polyarticular-course juvenile idiopathic arthritis (pcJIA). Methods This three-part, randomised, placebo-controlled, double-blind withdrawal study ( NCT00988221 ) included who had active pcJIA ≥6 months and inadequate responses to methotrexate. During part 1, received open-label every 4 weeks (8 or 10 mg/kg body weight (BW) <30 kg; 8 BW ≥30 kg). At week 16, ≥JIA-American College...
<h3>Objectives</h3> This study compared the efficacy and safety of subcutaneous (SC) versus intravenous (IV) formulations tocilizumab in patients with rheumatoid arthritis an inadequate response to disease-modifying antirheumatic drugs (DMARD). <h3>Methods</h3> Patients (n=1262) were randomly assigned receive tocilizumab-SC 162 mg weekly+placebo-IV every 4 weeks or tocilizumab-IV 8 mg/kg weeks+placebo-SC weekly combination traditional DMARD. The primary outcome was demonstrate...
Tocilizumab is a humanized anti-interleukin-6 receptor antibody for treating rheumatoid arthritis. Pharmacokinetic/pharmacodynamic analysis was performed on the 24-week double-blind parts of 2 randomized, controlled trials: SUMMACTA and BREVACTA. compared subcutaneous tocilizumab 162 mg every week to intravenous 8 mg/kg 4 weeks, whereas BREVACTA evaluated weeks versus placebo. In addition noncompartmental analysis, 2-compartment population pharmacokinetic model, with first-order absorption...
Abstract Background An objective of the phase 3 HELP Study was to investigate effect lanadelumab on health‐related quality life (HRQoL) in patients with hereditary angioedema (HAE). Methods Patients HAE‐1/2 received either 150 mg every 4 weeks (q4wks; n = 28), 300 q4wks ( 29), 2 (q2wks; 27), or placebo 41) for 26 (days 0–182). The Angioedema Quality Life Questionnaire (AE‐QoL) administered monthly, consisting four domain (functioning, fatigue/mood, fears/shame, nutrition) and total scores....
Lanadelumab demonstrated efficacy in preventing hereditary angioedema (HAE) attacks the phase 3 HELP Study.To assess time to onset of effect and long-term lanadelumab, based on exploratory findings from Study.Eligible patients with HAE type I/II received lanadelumab 150 mg every 4 weeks (q4wks), 300 q4wks, q2wks, or placebo. Ad hoc analyses evaluated day 0-69 using a Poisson regression model accounting for overdispersion. Least-squares mean monthly attack rate was compared Intrapatient...
Combining the experimental efficiency of a murine hepatic in vitro drug biotransformation system with silico genetic analysis produces model that can rapidly analyze interindividual differences metabolism. This was tested by using two clinically important drugs, testosterone and irinotecan, whose metabolism previously well characterized. The metabolites produced after these drugs were incubated systems prepared from 15 inbred mouse strains measured. Strain-specific rate 16...
Acetaminophen-induced liver toxicity is the most frequent precipitating cause of acute failure and transplant, but contemporary medical practice has mainly focused on patient management after a injury been induced. An integrative genetic, transcriptional, two-dimensional NMR-based metabolomic analysis performed using multiple inbred mouse strains, along with knowledge-based filtering these data, identified betaine-homocysteine methyltransferase 2 ( Bhmt2 ) as diet-dependent genetic factor...
Abstract Background Patients with hereditary angioedema C1 inhibitor deficiency or dysfunction have burdensome recurrent attacks. The safety, efficacy, and health‐related quality of life (HRQoL) outcomes (C1‐INH) prophylaxis (intravenously administered) in patients aged 6‐11 years were investigated. Methods Eligible enrolled a randomized, single‐blind, crossover, phase 3 trial. After 12‐week baseline observation period (BOP), received 500 1000 U C1‐INH, twice weekly, for 12 weeks before...
Objective The anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) may contribute to the pathogenesis of systemic lupus erythematosus. safety, tolerability, and pharmacodynamics selective Bcl-2 inhibitor venetoclax (ABT-199) were assessed in women with Methods A phase 1, double-blind, randomized, placebo controlled study evaluated single ascending doses (10, 30, 90, 180, 300, 500 mg) multiple (2 cycles; 60, 120, 240, 400, 600 mg for 1 week, then 3 weeks off per cycle) orally administered...
Using first-principles calculations, the elastic constants, thermodynamic properties and structural phase transition of NbN under high pressure are investigated by means pseudopotential plane-waves method, in addition to effect metallic bonding on its hardness. Three candidate structures chosen investigate NbN, namely, rocksalt (NaCl), NiAs WC types. On basis third-order Birch-Murnaghan equation states, Pt (Pt=200.64 GPa) between NaCl is predicted for first time. Elastic formation...
Abstract Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome, which emerges as major public health problem. Deficiency in methyl donors (folate and vitamin B12) during gestation lactation frequent humans produces foetal programming effects with small birth weight liver steatosis at day 21 (d21), rat pups. We investigated the fetal on rats born from deficient mothers (iMDD) subsequently subjected to normal diet after d21 high fat (HF) d50. observed increased...
Using first-principles calculations, the elastic constant, structural phase transition and effect of metallic bonding on hardness OsN2 under high pressure are investigated by means pseudopotential plane-waves method. Five candidate structures chosen to investigate for OsN2, namely, pyrite, CoSb2-type, marcasite, simple hexagonal tetragonal structures. A comparison among formation energies explains synthesis marcasite pressure. On basis third-order Birch-Murnaghan equation states, Pt (Pt=223...
Abstract Motivation: Comparative metabolic profiling by nuclear magnetic resonance (NMR) is showing increasing promise for identifying inter-individual differences to drug response. Two dimensional (2D) 1H13C NMR can reduce spectral overlap, a common problem of 1D 1H NMR. However, the peak alignment tools spectra are not well suited 2D An automated and statistically robust method aligning peaks required enable comparative metabonomic analysis using Results: A novel statistical was developed...
BackgroundHereditary angioedema (HAE) with C1 inhibitor deficiency (C1-INH) is characterized by swelling of subcutaneous and/or submucosal tissues.ObjectiveTo evaluate efficacy/safety fixed-dose plasma-derived C1-INH (pdC1-INH) liquid for HAE attack prevention (NCT02584959).MethodsEligible patients were ≥12 years ≥2 monthly attacks prescreening or pre–long-term prophylaxis. In a partial crossover design, 80% randomized to placebo pdC1-INH 14 weeks and crossed over from active vice versa...
Hydration status is a critical indicator for human health, yet there are relatively few studies on monitoring the hydration of body. Traditional methods have shortcomings such as being invasive, time-consuming to detect, and not real time. Recently, microwave has attracted research interest widely. This approach noninvasive based change dielectric properties tissues with different statuses. In this article, fused learning enhancing method proposed accurately monitor by using an ultrawideband...