A5101869041- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nausea and vomiting management
- Autoimmune Bullous Skin Diseases
- Hemophilia Treatment and Research
- Urticaria and Related Conditions
- Anesthesia and Pain Management
- Thyroid Disorders and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac tumors and thrombi
- Abdominal vascular conditions and treatments
- Coronary Interventions and Diagnostics
- Pathogenesis and Treatment of Hiccups
- Nursing Diagnosis and Documentation
- Chronic Myeloid Leukemia Treatments
- Mast cells and histamine
- HIV-related health complications and treatments
- Organ Transplantation Techniques and Outcomes
- Coronary Artery Anomalies
- Spine and Intervertebral Disc Pathology
- Erythropoietin and Anemia Treatment
- Sympathectomy and Hyperhidrosis Treatments
- PI3K/AKT/mTOR signaling in cancer
- Healthcare Systems and Practices
BLK Super Speciality Hospital
2019-2025
Takeda (United States)
2013-2021
Institute of Post Graduate Medical Education and Research
2021
University of Mississippi Medical Center
2020
State Street (United States)
2020
American College of Allergy, Asthma and Immunology
2020
Lexington City Schools
2017-2019
Tata Memorial Hospital
2016
Advanced Centre for Treatment, Research and Education in Cancer
2016
Comprehensive Clinical Research
2015
BackgroundHereditary angioedema (HAE) with C1-inhibitor deficiency is associated painful, potentially fatal attacks affecting subcutaneous or submucosal tissues.ObjectiveTo evaluate HAE burden from the patients' perspective.MethodsThis was a noninterventional survey of patients in United States, conducted March 17 to April 28, 2017. Patients were recruited through US Hereditary Angioedema Association. Key eligibility criteria included following: (1) aged 18 years and older, (2) self-reported...
Chronic obstructive pulmonary disease (COPD) exacerbations account for a substantial proportion of COPD-related costs.To describe COPD exacerbation patterns and assess the association between frequency health care resource utilization (HCRU) costs in patients with Medicare population.A retrospective cohort study utilizing data from large US national plan was conducted including diagnosis during January 1, 2007 to December 31, 2012, aged 40-89 years continuously enrolled Advantage...
Objective: To examine the burden of depression on work productivity. Methods: Full-time employees with diagnosed were surveyed using Patient Health Questionnaire for severity, and Work Performance Productivity Activity Impairment (WPAI) questionnaire absenteeism presenteeism. Results: Of 1051 depression, 40.3% had no depressive symptoms at time survey, 30.4% mild 15.8% moderate 7.8% moderately severe 5.8% depression. All levels associated decreased Presenteeism was positively severity...
Abstract Background Hereditary angioedema (HAE) is a rare, debilitating, genetic disease characterized by unpredictable, recurrent, and potentially fatal swelling of the skin mucous membranes. We conducted noninterventional, cross-sectional, web-based survey patients with self-reported diagnosis HAE type 1/2 in Australia, Austria, Canada, France, Germany, Spain, Switzerland, United Kingdom to gain comprehensive real-world understanding characteristics its burden from perspective patient. The...
Abstract Background An objective of the phase 3 HELP Study was to investigate effect lanadelumab on health‐related quality life (HRQoL) in patients with hereditary angioedema (HAE). Methods Patients HAE‐1/2 received either 150 mg every 4 weeks (q4wks; n = 28), 300 q4wks ( 29), 2 (q2wks; 27), or placebo 41) for 26 (days 0–182). The Angioedema Quality Life Questionnaire (AE‐QoL) administered monthly, consisting four domain (functioning, fatigue/mood, fears/shame, nutrition) and total scores....
We describe a young male patient who suffered myocardial infarction and was discovered to have biatrial myxoma where stalks originated from opposite sides at the same point of atrial septum, also described as "myxoma twins". The rarity having mirror image among cardiac myxomas, complicated by an even rarer event coronary embolism in such milieu, prompted us present following case report.
To assess the likelihood of subsequent chemotherapy-induced nausea and vomiting (CINV) events following a first chemotherapy administration CINV event in patients receiving single-day low, moderately, or highly emetogenic (LEC, MEC, HEC).A retrospective analysis was conducted utilizing Georgia Cancer Specialists, Florida ACORN electronic medical records databases (April 2006 through July 2009). Patients were included who received more than one LEC, HEC (oral intravenous) with no 3 months...
It is recommended that patients initiate triple antiemetic therapy with one of the 5-hydroxytryptamine receptor antagonists (5-HT(3) RAs), aprepitant (or its intravenous prodrug fosaprepitant) and dexamethasone prior to start highly emetogenic chemotherapy (HEC). However, impact 5-HT(3) RA selection within regimens on risk uncontrolled chemotherapy-induced nausea vomiting (CINV) HEC has not been well studied.To assess likelihood an CINV event following prophylaxis palonosetron +...
BACKGROUND: Despite the importance of early detection, delayed diagnosis chronic obstructive pulmonary disease (COPD) is relatively common. Approximately 12 million people in United States have undiagnosed COPD. Diagnosis COPD essential for timely implementation interventions, such as smoking cessation programs, drug therapies, and rehabilitation, which are aimed at improving outcomes slowing progression. OBJECTIVE: To develop validate a predictive model to identify patients likely using...
Abstract ST‐segment elevation myocardial infarction (STEMI) is associated with increased mortality and morbidity. Although remarkable progress has been made in the management of STEMI high‐income countries, contemporary data to evaluate processes outcomes care India limited. The North Indian (NORIN STEMI) registry a prospective cohort study based at government funded largely free cost tertiary medical centers New Delhi, India. These hospitals serve large proportion patients lower...
Background: There is limited real-world evidence on hereditary angioedema (HAE) patient characteristics and health-care resource utilization (HCRU); in addition, pediatric patients have been described small cohorts. Objective: To describe characteristics, treatment patterns, HCRU among adult treated for HAE a large U.S. cohort. Methods: This retrospective cohort study used an administrative claims data base (January 2006 to September 2015). Eligible with either ≥1 pharmacy claim...
Adoption of the National Coverage Determination for ESA agents has resulted in decreased use ESAs and increased transfusions as well delays anemia treatment lower mean Hb levels at time treatment.
Background: There is limited real-world evidence on hereditary angioedema (HAE) patient characteristics and health-careresource utilization (HCRU); in addition, pediatric patients have been described small cohorts.Objective: To describe characteristics, treatment patterns, HCRU among adult treatedfor HAE a large U.S. cohort.Methods: This retrospective cohort study used an administrative claims data base (January 2006 to September 2015).Eligible with either greater than or equal one pharmacy...
In Indian settings pulmonary tuberculosis remains the most common diagnosis in a patient presenting with constitutional symptoms, hemoptysis and lung opacities. We describe case report of fifty-year-old woman who was receiving empirical anti-tubercular drugs for metastatic illness to lungs arising from primary angiosarcoma right atrium. This rare entity misdiagnosed typical echocardiographic findings suggested this diagnosis.
Erosion of a peripancreatic artery into the pseudocyst as result enzymatic digestion vessel wall gives rise to pancreatic pseudoaneurysm (PSA), which is rare complication seen in patients with chronic pancreatitis.(1) Angiographic embolization treatment method for acute hemorrhage from PSA has become increasingly popular. Here we report unique case bleeding giant where single had blood supply originating branches both celiac and superior mesenteric artery.
Hereditary angioedema (HAE) with C1-esterase inhibitor (C1-INH) deficiency is a rare disease associated painful, potentially fatal swelling episodes affecting subcutaneous or submucosal tissues. HAE attacks recur unpredictable severity and frequency throughout patients’ lives; long-term prophylaxis essential for some patients. In the absence of head-to-head studies, indirect treatment comparison (ITC) prophylactic agents valid approach to evaluate comparative efficacy. We conducted an ITC...
Stent dislodgment during percutaneous coronary intervention is a rare complication. We report case of successful retrieval deformed stent through alternative transfemoral approach while performing transradial procedure when the could not be retrieved safely from route.
Background: Dabigatran was the first novel oral anticoagulant (OAC) approved in US for stroke risk reduction patients with non-valvular atrial fibrillation (NVAF). The aim of this study to evaluate healthcare resource utilization (HCRU) and costs among newly diagnosed NVAF who were treated dabigatran or warfarin real world setting. Methods: Medical pharmacy claims from HealthCore Integrated Research Database used identify initiated during 10/1/2010-12/31/2011. index date defined as OAC claim...
We present a case of Tricuspid valve Aspergillus endocarditis with saddle shaped massive pulmonary embolism occurring in an immunocompetent host. The patient was managed uniquely by endarterectomy (PEA) and combination antifungal chemotherapy Liposomal amphotericin-B + caspofungin.