Mayank Goyal
A5080100010- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Clinical practice guidelines implementation
- Neurosurgical Procedures and Complications
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological Disorders and Treatments
- Advanced X-ray and CT Imaging
- Cardiovascular Health and Disease Prevention
- Medical Imaging and Analysis
- Renal and Vascular Pathologies
- Antiplatelet Therapy and Cardiovascular Diseases
University of Calgary
2016-2025
Foothills Medical Centre
2016-2025
Indian Institute of Technology Bombay
2025
Mayo Clinic in Arizona
2016-2025
Allen Institute for Brain Science
2014-2024
Mayo Clinic
2024
WinnMed
2024
Calgary Laboratory Services
2012-2024
Humanitas University
2024
University of British Columbia
2013-2024
Among patients with a proximal vessel occlusion in the anterior circulation, 60 to 80% of die within 90 days after stroke onset or do not regain functional independence despite alteplase treatment. We evaluated rapid endovascular treatment addition standard care acute ischemic small infarct core, intracranial arterial occlusion, and moderate-to-good collateral circulation.We randomly assigned participants receive (control group) plus use available thrombectomy devices (intervention group)....
Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy use of a stent retriever, addition t-PA, increases reperfusion rates and may improve long-term outcome.
We aimed to assess the safety and efficacy of thrombectomy for treatment stroke in a trial embedded within population-based reperfusion registry.During 2-year period at four centers Catalonia, Spain, we randomly assigned 206 patients who could be treated 8 hours after onset symptoms acute ischemic receive either medical therapy (including intravenous alteplase when eligible) endovascular with Solitaire stent retriever (thrombectomy group) or alone (control group). All had confirmed proximal...
Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach more effective than t-PA alone uncertain.
Acute rates of recanalization after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) in proximal vessel occlusion have been estimated sparingly, typically using transcranial Doppler (TCD). We aimed to study acute IV rt-PA CT angiogram-proven (internal carotid artery [ICA], M1 middle cerebral [MCA], M2-MCA, and basilar artery) occlusions their effects on outcome.The angiogram database the Calgary stroke program was reviewed for period 2002 2009. All patients with receiving...
In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy.We conducted a trial at 41 academic tertiary care centers in China to evaluate thrombectomy with or without patients stroke. Patients stroke from large-vessel occlusion anterior circulation were randomly assigned 1:1 ratio undergo alone (thrombectomy-alone group) preceded by alteplase, dose 0.9 mg per kilogram body weight, administered within...
To describe the use of an imaging selection tool, multiphase computed tomographic (CT) angiography, in patients with acute ischemic stroke (AIS) and to demonstrate its interrater reliability ability help determine clinical outcome.The local ethics board approved this study. Data are from pilot phase PRoveIT, a prospective observational study analyzing utility multimodal triage AIS. Patients underwent baseline unenhanced CT, single-phase CT angiography head neck, perfusion CT. Multiphase...
Background and Purpose— Quantification of early ischemic changes (EIC) may predict functional outcome in patients with basilar artery occlusion (BAO). We tested the validity a novel CT score, posterior circulation Acute Stroke Prognosis Early score (pc-ASPECTS). Methods— Pc-ASPECTS allots 10 points. Two points each are subtracted for EIC midbrain or pons 1 point left right thalamus, cerebellum PCA-territory, respectively. studied 2 different populations: (1) suspected vertebrobasilar...
Revascularization after endovascular therapy for acute ischemic stroke is measured by the Thrombolysis In Cerebral Infarction (TICI) scale, yet variability exists in scale definitions. We examined degree of reperfusion with expanded TICI (eTICI) and association outcomes HERMES collaboration recent trials.The Imaging Core, blind to all other data, evaluated angiography HERMES. A battery scores (mTICI, TICI, TICI2C) was used define initial target occlusion defined non-invasive imaging...
Background and Purpose— Endovascular strategies provide unique opportunity to correlate angiographic measures of collateral circulation at the time endovascular therapy. We conducted systematic analyses collaterals conventional angiography on recanalization, reperfusion, clinical outcomes in treatment arm Interventional Management Stroke (IMS) III trial. Methods— Prospective evaluation was via central review subjects treated with therapy IMS (n=331). Collateral grade before assessed American...
<h3>BACKGROUND AND PURPOSE: </h3> The regional leptomeningeal score is a strong and reliable imaging predictor of good clinical outcomes in acute anterior circulation ischemic strokes can therefore be used for based patient selection. Efforts to determine biological determinants collateral status are needed if techniques alter behavior extend time windows succeed. <h3>MATERIALS METHODS: This was retrospective Institutional Review Board–approved study patients with stroke M1 middle cerebral...
Background and Purpose— Mechanical thrombectomy using stent retriever devices have been advocated to increase revascularization in intracranial vessel occlusion. We present the results of a large prospective study on use Solitaire Flow Restoration patients with acute ischemic stroke. Methods— Thrombectomy for Acute Revascularization was an international, multicenter, prospective, single-arm anterior circulation strokes treated within 8 hours symptom onset. Strict criteria site selection were...
Purpose To study the relationship between functional independence and time to reperfusion in Solitaire with Intention for Thrombectomy as Primary Endovascular Treatment Acute Ischemic Stroke (SWIFT PRIME) trial patients disabling acute ischemic stroke who underwent endovascular therapy plus intravenous tissue plasminogen activator (tPA) administration versus tPA alone investigate variables that affect spent during discrete steps. Materials Methods Data were analyzed from SWIFT PRIME trial, a...
Rationale Early reperfusion in patients experiencing acute ischemic stroke is critical, especially for with large vessel occlusion who have poor prognosis without revascularization. Solitaire™ stent retriever devices been shown to immediately restore vascular perfusion safely, rapidly, and effectively occlusions. Aim The aim of the study was demonstrate that, among vessel, anterior circulation received intravenous tissue plasminogen activator, treatment Solitaire revascularization reduces...