A5019876508- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Nerve Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Pain Mechanisms and Treatments
- Nerve Injury and Rehabilitation
- Lanthanide and Transition Metal Complexes
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Neuropathies and Disorders
- Meningioma and schwannoma management
- Dental Radiography and Imaging
- Cancer, Hypoxia, and Metabolism
- Multiple Sclerosis Research Studies
University Hospital Heidelberg
2016-2025
Heidelberg University
2016-2025
Heidelberg University
2009-2025
Ferioli & Gianotti (Italy)
2024
Klinik und Poliklinik für Neurologie
2024
Universität Hamburg
2015-2024
University Medical Center Hamburg-Eppendorf
2015-2024
Universitätsklinikum Würzburg
2017-2024
University Hospital of Bern
2024
German Cancer Research Center
2011-2023
Bevacizumab is approved for the treatment of patients with progressive glioblastoma on basis uncontrolled data. Data from a phase 2 trial suggested that addition bevacizumab to lomustine might improve overall survival as compared monotherapies. We sought determine whether combination would result in longer than alone among at first progression glioblastoma.We randomly assigned after chemoradiation 2:1 ratio receive plus (combination group, 288 patients) or (monotherapy 149 patients). The...
To compare changes in signal intensity (SI) ratios of the dentate nucleus (DN) and globus pallidus (GP) to those other structures on unenhanced T1-weighted magnetic resonance (MR) images between linear macrocyclic gadolinium-based contrast agents (GBCAs).The study was approved by ethical committee University Heidelberg (reference no. S-324/2014). Owing retrospective character study, did not require any written informed consent. Two groups 50 patients who underwent at least six consecutive MR...
Brain extraction is a critical preprocessing step in the analysis of MRI neuroimaging studies and influences accuracy downstream analyses. The majority brain algorithms are, however, optimized for processing healthy brains thus frequently fail presence pathologically altered or when applied to heterogeneous datasets. Here we introduce new, rigorously validated algorithm (termed HD-BET) relying on artificial neural networks that aims overcome these limitations. We demonstrate HD-BET...
<h3>Importance</h3> Optimal management of sedation and airway during thrombectomy for acute ischemic stroke is controversial due to lack evidence from randomized trials. <h3>Objective</h3> To assess whether conscious superior general anesthesia early neurological improvement among patients receiving thrombectomy. <h3>Design, Setting, Participants</h3> SIESTA (Sedation vs Intubation Endovascular Stroke Treatment), a single-center, randomized, parallel-group, open-label treatment trial with...
Formation of fibrin is critical for limiting blood loss at a site vessel injury (hemostasis), but may also contribute to vascular thrombosis. Hereditary deficiency factor XII (FXII), the protease that triggers intrinsic pathway coagulation in vitro, not associated with spontaneous or excessive injury-related bleeding, indicating FXII required hemostasis. We demonstrate inhibition protects mice from ischemic brain injury. After transient middle cerebral artery occlusion, volume infarcted...
In ischemic stroke, the necrotic core is surrounded by a zone of inflammation, in which delayed cell death aggravates initial insult. Here, we provide evidence that receptor for advanced glycation end products (RAGE) functions as sensor and contributes to inflammation brain damage. The RAGE ligand high mobility group box 1 (HMGB1) was elevated serum stroke patients released from tissue mouse model cerebral ischemia. A neutralizing anti-HMGB1 antibody HMGB1 A, an antagonist at RAGE,...
Purpose To evaluate whether radiomic feature–based magnetic resonance (MR) imaging signatures allow prediction of survival and stratification patients with newly diagnosed glioblastoma improved accuracy compared that established clinical radiologic risk models. Materials Methods Retrospective evaluation data was approved by the local ethics committee informed consent waived. A total 119 (allocated in a 2:1 ratio to discovery [n = 79] or validation 40] set) were subjected feature extraction...
Background— Ischemic stroke is a frequent and serious disease with limited treatment options. Platelets can adhere to hypoxic cerebral endothelial cells by binding of their glycoprotein (GP) Ib receptor von Willebrand factor. Exposure subendothelial matrix proteins further facilitates firm attachment platelets the vessel wall collagen GPVI receptor. In present study, we addressed pathogenic role GPIb, GPVI, aggregation GPIIb/IIIa in experimental mice. Methods Results— Complete blockade GPIbα...
Background and Purpose— Dabigatran-etexilate (DE) recently has been approved for stroke prevention in atrial fibrillation. However, lack of effective antagonists represents a major concern the event intracerebral hemorrhage (ICH). The aims present study were to establish murine model ICH associated with dabigatran, test efficacy different hemostatic factors preventing hematoma growth. Methods— In C57BL/6 mice receiving DE (4.5 or 9.0 mg/kg), vivo vitro coagulation assays dabigatran plasma...
Abstract Mutated isocitrate dehydrogenase 1 ( IDH1 ) defines a molecularly distinct subtype of diffuse glioma 1–3 . The most common mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours shared clonal neoepitope that is presented on major histocompatibility complex (MHC) class II 4,5 An IDH1(R132H)-specific peptide vaccine (IDH1-vac) induces specific therapeutic T helper cell responses are effective against IDH1(R132H) + tumours syngeneic MHC-humanized mice 4,6–8 Here...
Abstract The recent identification of IDH mutations in gliomas and several other cancers suggests that this pathway is involved oncogenesis; however effector functions are complex yet incompletely understood. To study the regulatory effects on hypoxia-inducible-factor 1-alpha ( HIF1A ), a driving force hypoxia-initiated angiogenesis, we analyzed mRNA expression profiles 288 glioma patients show decreased targets single-gene level, strong inhibition upstream regulators such as downstream...