A5026866006- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Multiple Sclerosis Research Studies
- Vascular Malformations Diagnosis and Treatment
- MRI in cancer diagnosis
- Stroke Rehabilitation and Recovery
- Brain Metastases and Treatment
- Cardiovascular Health and Disease Prevention
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Moyamoya disease diagnosis and treatment
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Neurological Complications and Syndromes
- Fetal and Pediatric Neurological Disorders
- Facial Nerve Paralysis Treatment and Research
University of Toronto
2014-2025
University of Ottawa
2015-2025
Ottawa Hospital
2015-2025
Ottawa Hospital Research Institute
2012-2024
Health Sciences Centre
2013-2023
University of Calgary
2009-2023
Sunnybrook Health Science Centre
2013-2023
University of Alberta
2017-2023
University of Cincinnati
2013-2023
MIND Research Institute
2023
Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critical. However, paroxysmal atrial often asymptomatic likely to go undetected untreated in the routine care patients with ischemic or transient attack (TIA).
<b>BACKGROUND AND PURPOSE:</b> Clot extent, location, and collateral integrity are important determinants of outcome in acute stroke. We hypothesized that a novel clot burden score (CBS) (CS) clinical radiologic outcomes serve as useful additional stroke predictors. <b>MATERIALS METHODS:</b> One hundred twenty-one patients with anterior circulation infarct presenting within 3 hours onset were reviewed. The Spearman correlation was performed to assess the between CBS CS measures. Patients...
Morbidity and mortality in spontaneous intracerebral hemorrhage (ICH) are correlated with hematoma progression. We hypothesized that the presence of tiny, enhancing foci ("spot sign") within acute hematomas is associated expansion.We prospectively studied 39 consecutive patients ICH by computed tomography angiography 3 hours symptom onset. Scans were reviewed readers. Patients dichotomized according to or absence spot sign. Clinical radiological outcomes compared between groups. The...
Background and Purpose— Many ischemic strokes or transient attacks are labeled cryptogenic but may have undetected atrial fibrillation (AF). We sought to identify those most likely subclinical AF. Methods— prospectively studied patients with stroke attack aged ≥55 years in sinus rhythm, without known AF, enrolled the intervention arm of 30 Day Event Monitoring Belt for Recording Atrial Fibrillation After a Cerebral Ischemic (EMBRACE) trial. Participants underwent baseline 24-hour Holter ECG...
We investigated whether computed tomography (CT) perfusion-derived cerebral blood flow (CBF) and volume (CBV) could be used to differentiate between penumbra infarcted gray matter in a limited, exploratory sample of acute stroke patients.Thirty patients underwent noncontrast CT (NCCT), angiography (CTA), perfusion (CTP) scan within 7 hours onset, NCCT CTA at 24 hours, 5 days. Twenty-five met the criteria for inclusion were subsequently divided into 2 groups: those with recanalization (n=16)...
Primary angiitis of the central nervous system (PACNS) is a severe and ill-defined neurologic disease. The goal this study was to characterize presenting features, treatment, outcome PACNS in children (cPACNS) define predictors disease progression order identify high-risk patients with cPACNS.The cohort comprised consecutive diagnosed as having cPACNS based on clinical vascular imaging findings, including identification arterial stenosis conventional angiography or magnetic resonance (MR)...
<b>BACKGROUND AND PURPOSE:</b> Qualitative CT perfusion (CTP) assessment by using the Alberta Stroke Program Early Score (ASPECTS) allows rapid calculation of infarct extent for middle cerebral artery infarcts. Published thresholds exist noncontrast (NCCT) ASPECTS, which may distinguish outcome/complication risk, but early ischemic signs are difficult to detect. We hypothesized that different ASPECTS CTP parameters versus NCCT and these be superior at predicting clinical radiologic outcome...
Purpose: To determine whether admission computed tomography (CT) perfusion–derived permeability–surface area product (PS) maps differ between patients with hemorrhagic acute stroke and those nonhemorrhagic stroke. Materials Methods: This prospective study was institutional review board approved, all participants gave written informed consent. Forty-one who presented within 3 hours after symptom onset underwent two-phase CT perfusion imaging, which enabled PS measurement. Patients were...
Cerebral microbleeds (petechial hemorrhages) are a well-known consequence of cerebral amyloid angiopathy and chronic hypertension among other causes. We report 12 patients with clinically radiologically distinct microbleed phenomenon in the white matter.These were assessed at University Health Network (Toronto, Canada) between 2004 2014.Median age was 40 years (range, 27-63 years), 7 out women. All had brain magnetic resonance imaging during or immediately after an intensive care unit...
To systematically evaluate the diagnostic benefits and inter- intraobserver reliability of an incremental computed tomographic (CT) protocol in confirmation clinically suspected stroke, with combined imaging clinical data as reference standard.Institutional review board approval was obtained, participants gave informed consent. A total 191 patients (mean age, 67 years +/- 16 [standard deviation]; 105 men) strokelike symptoms no more than 3 hours duration were recruited. Blinded performed by...
Background and Purpose- Although perfusion abnormality is an increasingly important therapeutic target, the natural history of tissue at risk without reperfusion treatment understudied. Our objective was to determine how time affects penumbral salvage infarct growth in untreated acute ischemic stroke patients whether collateral status this relationship. Methods- We used a prospectively collected, multicenter registry assess who were not treated with intravenous thrombolysis or endovascular...
Background and Purpose— Although the computed tomographic angiography spot sign performs well as a biomarker for hematoma expansion (HE), is not routinely performed in emergency setting. We developed validated score to predict HE-based on noncontrast tomography (NCCT) findings spontaneous acute intracerebral hemorrhage. Methods— After developing single-center cohort of patients with hemorrhage (n=344), we it large clinical trial population (n=954) multicenter (n=241). The following NCCT...
Background and Purpose— Hematoma expansion in intracerebral hemorrhage is associated with higher morbidity mortality. The computed tomography (CT) angiographic spot sign highly predictive of expansion, but other morphological features such as fluid levels, density heterogeneity, margin irregularity may also predict particularly centres where CT angiography not readily available. Methods— Baseline noncontrast scans from patients enrolled the Predicting Growth Outcome Intracerebral Hemorrhage...
The Stroke Imaging Research (STIR) group, the Working Group of StrokeNet, American Society Neuroradiology, and Foundation Neuroradiology sponsored an imaging session workshop during Treatment Academy Industry Roundtable (STAIR) IX on October 5 to 6, 2015 in Washington, DC. purpose this roadmap was focus role future research clinical trials.This forum brought together stroke neurologists, neuroradiologists, neuroimaging scientists, members National Institute Neurological Disorders (NINDS),...
<h3>BACKGROUND AND PURPOSE:</h3> Good CTA collaterals independently predict good outcome in acute ischemic stroke. Our aim was to evaluate the role of collateral circulation and its added benefit over CTP-derived total volume as a predictor baseline NIHSS score, volume, hemorrhagic transformation, final infarct size, modified Rankin Scale score >2. <h3>MATERIALS METHODS:</h3> This retrospective study 395 patients with stroke dichotomized by recanalization (recanalization...
Intracerebral hemorrhage (ICH) is a devastating stroke type that lacks effective treatments. An imaging biomarker of ICH expansion-the computed tomography (CT) angiography spot sign-may identify subgroup could benefit from hemostatic therapy.To investigate whether recombinant activated coagulation factor VII (rFVIIa) reduces expansion among patients with sign-positive ICH.In parallel investigator-initiated, multicenter, double-blind, placebo-controlled randomized clinical trials in Canada...