A5105230587- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Policy and Management
- Acute Ischemic Stroke Management
- Primary Care and Health Outcomes
- Atrial Fibrillation Management and Outcomes
- Healthcare cost, quality, practices
- Emergency and Acute Care Studies
- Genomics and Rare Diseases
- Venous Thromboembolism Diagnosis and Management
- Meta-analysis and systematic reviews
- Heart Failure Treatment and Management
- Statistical Methods in Clinical Trials
- Dialysis and Renal Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Migration, Health and Trauma
- Cardiac Arrhythmias and Treatments
- BRCA gene mutations in cancer
- Hemodynamic Monitoring and Therapy
- Pharmaceutical industry and healthcare
- Pharmaceutical Economics and Policy
- Genetic factors in colorectal cancer
- Health Policy Implementation Science
- Diabetes Management and Education
- Bone health and osteoporosis research
St. Michael's Hospital
2015-2024
University of Toronto
2015-2024
Unity Health Toronto
2020-2024
University Health Network
2008-2024
Schwartz/Reisman Emergency Medicine Institute
2024
3M (United States)
2018-2024
Harvard University
2020-2024
Ottawa Hospital
1994-2022
Ottawa Hospital Research Institute
1994-2022
St Michael’s Hospital
2022
The Randomized Aldactone Evaluation Study (RALES) demonstrated that spironolactone significantly improves outcomes in patients with severe heart failure. Use of angiotensin-converting-enzyme (ACE) inhibitors is also indicated these patients. However, life-threatening hyperkalemia can occur when drugs are used together.We conducted a population-based time-series analysis to examine trends the rate prescriptions and hospitalization for ambulatory before after publication RALES. We linked...
Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critical. However, paroxysmal atrial often asymptomatic likely to go undetected untreated in the routine care patients with ischemic or transient attack (TIA).
Context Drug-drug interactions are a preventable cause of morbidity and mortality, yet their consequences in the community not well characterized. Objective To determine whether elderly patients admitted to hospital with specific drug toxicities were likely have been prescribed an interacting week prior admission. Design Three population-based, nested case-control studies. Setting Ontario, Canada, from January 1, 1994, December 31, 2000. Patients All Ontario residents aged 66 years or older...
<h3>Background.</h3> —Clinical prediction rules are decision-making tools for clinicians, containing variables from the history, physical examination, or simple diagnostic tests. <h3>Objective.</h3> —To review quality of recently published clinical and to suggest methodological standards their development evaluation. <h3>Data Sources.</h3> —Four general medical journals were manually searched 1991 through 1994. <h3>Study Selection.</h3> hundred sixty potentially eligible reports identified,...
Despite the use of warfarin, major systemic embolism remains an important complication in patients with heart-valve replacement. Although addition antiplatelet agents has potential to reduce this complication, their efficacy and safety when given combination warfarin are uncertain.
<h3>CLINICAL SCENARIO</h3> You are about to see a 76-year-old retired schoolteacher for the second time. first saw her in clinic month ago because of cognitive problems. Your evaluation at that time included Standardized Mini-Mental State Examination,<sup>1</sup>on which she scored 18 out possible 30 points, and physical examination was normal including no focal neurological signs. arranged investigations treatable causes dementia were negative, you thus feel has probable Alzheimer's...
OBJECTIVE--To determine whether recombinant human erythropoietin improves the quality of life and exercise capacity anaemic patients receiving haemodialysis. DESIGN--A double blind, randomised, placebo controlled study. SETTING--Eight Canadian university haemodialysis centres. PATIENTS--118 Patients aged 18-75 with haemoglobin concentrations less than 90 g/l, no causes anaemia other deficiency, serious diseases. INTERVENTIONS--Patients were randomised to three groups receive (n = 40),...
Warfarin is the most effective stroke prevention medication for high-risk individuals with atrial fibrillation, yet it often underused. This study examined magnitude of this problem in a large contemporary, prospective registry.We analyzed data from Registry Canadian Stroke Network, database consecutive patients admitted to 12 designated centers Ontario (2003 2007). We included an acute ischemic who (1) had known history fibrillation; (2) were classified as high risk systemic emboli...
<h3>CLINICAL SCENARIO</h3> You are about to see a 76-year-old retired schoolteacher for the second time. first saw her in clinic month ago because of cognitive problems. Your evaluation at that time included Standardized Mini-Mental State Examination,<sup>1</sup>on which she scored 18 out possible 30 points, and physical examination was normal including no focal neurological signs. arranged investigations treatable causes dementia were negative, you thus feel has probable Alzheimer's...
A RANDOMIZED controlled trial (RCT) is the most reliable method of assessing efficacy health care interventions.<sup>1,2</sup>Reports RCTs should provide readers with adequate information about what went on in design, execution, analysis, and interpretation trial. Such reports will help judge validity There have been several investigations evaluating how are reported. In an early study, Mahon Daniel<sup>3</sup>reviewed 203 drug trials published between 1956 1960 the<i>Canadian Medical...
<h3>Background</h3> Recent debate has emerged regarding the cardiovascular safety of selective cyclooxygenase 2 inhibitors and possible cardioprotective effect naproxen sodium. We compared rates acute myocardial infarction (AMI) among elderly patients dispensed inhibitors, naproxen, nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs). <h3>Methods</h3> conducted a population-based retrospective cohort study using administrative health care data from Ontario, Canada, April...
Background and Purpose— Many ischemic strokes or transient attacks are labeled cryptogenic but may have undetected atrial fibrillation (AF). We sought to identify those most likely subclinical AF. Methods— prospectively studied patients with stroke attack aged ≥55 years in sinus rhythm, without known AF, enrolled the intervention arm of 30 Day Event Monitoring Belt for Recording Atrial Fibrillation After a Cerebral Ischemic (EMBRACE) trial. Participants underwent baseline 24-hour Holter ECG...
Background— Although approximately one third of patients with heart failure (HF) visiting the emergency department (ED) are discharged home, little is known about their care and outcomes. Methods Results— We examined acute early outcomes HF who visited an ED were without hospital admission in Ontario, Canada, from April 2004 to March 2007. Among 50 816 (age, 76.4±11.6 years; 49.4% men) for HF, 16 094 (31.7%) admission. A total 4.0% died within 30 days admission, 1.3% 7 discharge ED. multiple...
In Brief Objective: To compare the operative outcomes of early and delayed cholecystectomy for acute cholecystitis. Background: Randomized trials comparing to cholecystitis have limited contemporary external validity. Furthermore, no study date has been large enough assess impact timing on frequency serious rare complications including bile duct injury death. Methods: This is a population-based retrospective cohort patients emergently admitted hospital with managed over period April 1, 2004,...