A5114377551- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cardiac Arrhythmias and Treatments
- Neurosurgical Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Traumatic Brain Injury and Neurovascular Disturbances
- Health Systems, Economic Evaluations, Quality of Life
- Botulinum Toxin and Related Neurological Disorders
- Cerebral Venous Sinus Thrombosis
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Obstructive Sleep Apnea Research
- Cardiovascular and Diving-Related Complications
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience of respiration and sleep
- Neurological Disorders and Treatments
- Clinical practice guidelines implementation
- Migraine and Headache Studies
- Pharmacological Effects and Toxicity Studies
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2016-2025
University of Toronto
2016-2025
Sunnybrook Research Institute
2010-2024
Beaumont Hospital
2024
Arcadia
2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Edinburgh College
2023
University of Edinburgh
2023
Institute for Clinical Evaluative Sciences
2008-2022
Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critical. However, paroxysmal atrial often asymptomatic likely to go undetected untreated in the routine care patients with ischemic or transient attack (TIA).
<b>BACKGROUND AND PURPOSE:</b> Clot extent, location, and collateral integrity are important determinants of outcome in acute stroke. We hypothesized that a novel clot burden score (CBS) (CS) clinical radiologic outcomes serve as useful additional stroke predictors. <b>MATERIALS METHODS:</b> One hundred twenty-one patients with anterior circulation infarct presenting within 3 hours onset were reviewed. The Spearman correlation was performed to assess the between CBS CS measures. Patients...
Morbidity and mortality in spontaneous intracerebral hemorrhage (ICH) are correlated with hematoma progression. We hypothesized that the presence of tiny, enhancing foci ("spot sign") within acute hematomas is associated expansion.We prospectively studied 39 consecutive patients ICH by computed tomography angiography 3 hours symptom onset. Scans were reviewed readers. Patients dichotomized according to or absence spot sign. Clinical radiological outcomes compared between groups. The...
Warfarin is the most effective stroke prevention medication for high-risk individuals with atrial fibrillation, yet it often underused. This study examined magnitude of this problem in a large contemporary, prospective registry.We analyzed data from Registry Canadian Stroke Network, database consecutive patients admitted to 12 designated centers Ontario (2003 2007). We included an acute ischemic who (1) had known history fibrillation; (2) were classified as high risk systemic emboli...
The 2017 update of Canadian Stroke Best Practice Recommendations for the Secondary Prevention is a collection current evidence-based recommendations intended use by clinicians across wide range settings. goal to provide guidance prevention ischemic stroke recurrence through identification and management modifiable vascular risk factors. include those related diagnostic testing, diet lifestyle, smoking, hypertension, hyperlipidemia, diabetes, antiplatelet anticoagulant therapies, carotid...
The NAVIGATE ESUS randomized clinical trial found that 15 mg of rivaroxaban per day does not reduce stroke compared with aspirin in patients embolic undetermined source (ESUS); however, it substantially reduces risk atrial fibrillation (AF).OBJECTIVE To analyze whether is associated a reduction recurrent among who have an increased AF.DESIGN, SETTING, AND PARTICIPANTS Participants were stratified by predictors AF, including left diameter, frequency premature contractions, and HAVOC score,...
Atrial fibrillation (AF) is a major cause of preventable strokes. Screening asymptomatic individuals for AF may increase anticoagulant use stroke prevention.To evaluate 2 home-based screening interventions.This multicenter randomized clinical trial recruited from primary care practices aged 75 years or older with hypertension and without known AF. From April 5, 2015, to March 26, 2019, 856 participants were enrolled 48 practices.The control group received standard (routine follow-up plus...
Importance Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It unknown whether anticoagulation, which has proven benefit fibrillation, prevents patients and no Objective To compare anticoagulation vs antiplatelet therapy for secondary prevention cryptogenic evidence cardiopathy. Design, Setting, Participants Multicenter, double-blind, phase 3 randomized clinical trial 1015 participants cardiopathy, defined as P-wave terminal force...
To investigate the association between magnetic resonance (MR) imaging-depicted intraplaque hemorrhage (IPH) in carotid artery wall and risk of future ipsilateral cerebrovascular events men with asymptomatic moderate stenosis by using a rapid three-dimensional T1-weighted fat-suppressed spoiled gradient-echo sequence.The institutional ethics review board approved this retrospective chart waived requirement for written informed consent. All patients gave verbal consent at follow-up telephone...
<b>BACKGROUND AND PURPOSE:</b> Qualitative CT perfusion (CTP) assessment by using the Alberta Stroke Program Early Score (ASPECTS) allows rapid calculation of infarct extent for middle cerebral artery infarcts. Published thresholds exist noncontrast (NCCT) ASPECTS, which may distinguish outcome/complication risk, but early ischemic signs are difficult to detect. We hypothesized that different ASPECTS CTP parameters versus NCCT and these be superior at predicting clinical radiologic outcome...
Atrial fibrillation (AF) increases the risk of stroke and is associated with poor outcomes. Limited tools are available to evaluate clinical outcomes response thrombolysis in patients AF.We applied iScore (http://www.sorcan.ca/iscore), a validated score, consecutive an acute ischemic admitted centers Registry Canadian Stroke Network. The main outcome considered was favorable (defined as modified Rankin scale 0-2) at discharge after thrombolysis. Secondary included intracerebral hemorrhage,...
Background: Longitudinal, patient-level data on resource use and costs after an ischemic stroke are lacking in Canada. The objectives of this analysis were to calculate for the first year post-stroke determine impact disability costs. Methodology: Economic Burden Ischemic Stroke (BURST) Study was a one-year prospective study with cohort patients recruited at 12 Canadian centres. Clinical history, disability, health preference utilization information collected discharge, three months, six...
Intracerebral hemorrhage (ICH) is a devastating stroke type that lacks effective treatments. An imaging biomarker of ICH expansion-the computed tomography (CT) angiography spot sign-may identify subgroup could benefit from hemostatic therapy.To investigate whether recombinant activated coagulation factor VII (rFVIIa) reduces expansion among patients with sign-positive ICH.In parallel investigator-initiated, multicenter, double-blind, placebo-controlled randomized clinical trials in Canada...