A5035907158- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Blood Pressure and Hypertension Studies
- Aortic Thrombus and Embolism
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Acute Ischemic Stroke Management
- Cardiac Arrhythmias and Treatments
- Cardiac tumors and thrombi
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Intracranial Aneurysms: Treatment and Complications
- Congenital Heart Disease Studies
Columbia University
2015-2024
IVI Madrid Clinic
2024
NewYork–Presbyterian Hospital
1997-2023
Columbia University Irving Medical Center
2014-2023
New York Hospital Queens
2004-2023
New York Proton Center
2023
San Salvatore Hospital
2023
University of Macerata
2023
Presidio Ospedaliero
2023
Istituto Nazionale di Riposo e Cura per Anziani
2023
Background — Patent foramen ovale (PFO) is associated with stroke, but there are no randomized studies to evaluate the efficacy of antithrombotic therapies. Methods and Results The PFO in Cryptogenic Stroke Study was a 42-center study that evaluated transesophageal echocardiographic findings patients randomly assigned warfarin or aspirin Warfarin-Aspirin Recurrent Study. In this study, 630 stroke were enrolled, whom 312 (49.5%) 318 (50.5%) aspirin. Of these, 265 experienced cryptogenic 365...
It is unknown whether warfarin or aspirin therapy superior for patients with heart failure who are in sinus rhythm.
We aimed to create an index stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the was related PFO.Using data from 12 component studies, we used generalized linear mixed models predict presence of PFO among CS, and derive a simple CS. estimated stratum-specific PFO-attributable fraction stroke/TIA recurrence rates.Variables associated in CS included younger age, cortical on neuroimaging, absence these factors: diabetes, hypertension, smoking,...
Recent data suggest that a thrombogenic atrial substrate can cause stroke in the absence of fibrillation. Such an cardiopathy may explain some proportion cryptogenic strokes.
Background and Purpose— Although left atrial enlargement (LAE) increases incident stroke risk, the association with recurrent is less clear. Our aim was to determine of LAE most likely related embolism (cryptogenic cardioembolic) all ischemic recurrences. Methods— We followed 655 first patients in Northern Manhattan Stroke Study for ≤5 years. LA size from 2D echocardiography categorized as normal (52.7%), mild (31.6%), moderate–severe (15.7%). used Cox proportional hazard models calculate...
Importance Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It unknown whether anticoagulation, which has proven benefit fibrillation, prevents patients and no Objective To compare anticoagulation vs antiplatelet therapy for secondary prevention cryptogenic evidence cardiopathy. Design, Setting, Participants Multicenter, double-blind, phase 3 randomized clinical trial 1015 participants cardiopathy, defined as P-wave terminal force...
Background and Purpose —Although the cause of stroke among patients with patent foramen ovale (PFO) may be due to paradoxical cerebral embolism (PCE), this mechanism is often difficult prove. The aim our study was evaluate association between brain imaging findings suggestive PFO ischemic patients. Methods —As part Northern Manhattan Stroke Study, 95 first over age 39 underwent transesophageal echocardiography (TEE) for evaluation a cardiac source embolism. subtype determined by modified...
Patent foramen ovale is associated with ischemic stroke in patients without a clearly identifiable etiology for (cryptogenic stroke). Paradoxical embolization thought to be potential mechanism. However, patent also found known cause of stroke. Therefore, using contrast transesophageal echocardiography, we characterized the cryptogenic assess morphological factors that may contribute paradoxical embolization.Contrast echocardiographic studies 74 consecutive referred were reviewed....
Background and Purpose —The association between left atrial size ischemic stroke is controversial has been suggested to exist only in men be mediated by ventricular mass. Data are available almost exclusively for white patients. The purpose of this study was evaluate the a multiethnic population. Methods —A population-based case-control conducted 352 patients aged >39 years with first 369 age-, gender-, race-ethnicity–matched community controls. Left diameter measured 2-dimensional...
Abstract —Asymmetric dimethylarginine (ADMA), a compound detectable in human plasma, is an endogenous inhibitor of NO synthase. Endothelial dysfunction early event atherogenesis, and large-vessel atherosclerosis major cause morbidity mortality patients with type 2 diabetes mellitus. Fifty mellitus were studied at baseline 5 hours after ingestion high-fat meal. Plasma ADMA measured by using high-performance liquid chromatography increased from 1.04±0.99 to 2.51±2.27 μmol/L ( P <0.0005)....
Objective Left atrial (LA) maximum volume (LAVmax) is an indicator of left ventricular (LV) diastolic function. However, LAVmax also influenced by systolic events, whereas the LA minimum (LAVmin) directly exposed to LV pressure. The authors hypothesised that LAVmin may be a better correlate function than LAVmax. Design Cross-sectional. Setting University hospital. Patients 357 participants from community-based cohort study. Methods volumes and reservoir function, measured as total emptying...
Background and Purpose Patent foramen ovale (PFO) is associated with stroke of unknown etiology or cryptogenic stroke. However, optimal treatment to prevent recurrence in patients PFO not clearly defined. Since represents a surgically repairable lesion, interest closing it high. This report reviews our experience who underwent surgical closure were followed for neurological events. Methods We 28 (17 men, 11 women; mean age, 41±13 years) transesophageal echocardiograpy–defined had undergone...
Background— Aortic arch plaques are a risk factor for ischemic stroke. Although the stroke mechanism is conceivably thromboembolic, no randomized studies have evaluated efficacy of antithrombotic therapies in preventing recurrent events. Methods and Results— The relationship between events was studied 516 patients with who were double-blindly to treatment warfarin or aspirin as part Patent Foramen Ovale Cryptogenic Stroke Study (PICSS), based on Warfarin-Aspirin Recurrent (WARSS). Plaque...
Increased arterial stiffness and wave reflection have been reported in heart failure with normal ejection fraction (HFNEF) asymptomatic left ventricular (LV) diastolic dysfunction, a precursor of HFNEF. It is unclear whether women, who higher frequency HFNEF, are more vulnerable than men to the deleterious effects on LV function. We investigated, large community-based cohort, sex differences exist relationship among stiffness, reflection, Arterial were assessed 983 participants from...
Left ventricular dysfunction (LVD) is associated with cardiovascular mortality. Its association ischemic stroke has been mainly documented after myocardial infarction. The risk LVD, especially of mild degree, in the general population unclear. purpose this study was to evaluate relationship between LVD and a multiethnic cohort.LV systolic function assessed by transthoracic 2-dimensional echocardiography subset subjects from Northern Manhattan Study (NOMAS), 270 patients first 288 age-,...
A causal relationship between patent foramen ovale (PFO) and migraine has been hypothesized, improvement of frequency severity after percutaneous PFO closure reported. Population-based data on the are sparse, however. The objective this study was to examine association among stroke-free individuals in an urban, population-based, multiethnic cohort.As a part ongoing Northern Manhattan Study (NOMAS), 1101 subjects were assessed for self-reported history migraine. presence by transthoracic...
Electrocardiographic left atrial abnormality has been associated with stroke independently of fibrillation (AF), suggesting that thromboembolism may occur in the absence AF. If true, we would expect an association cryptogenic or cardioembolic rather than noncardioembolic stroke.We conducted a case-cohort analysis Northern Manhattan Study, prospective cohort study risk factors. P-wave terminal force lead V1 was manually measured from baseline ECGs participants sinus rhythm who subsequently...