A5019703573- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Esophageal and GI Pathology
- Cardiac Health and Mental Health
- Cardiovascular Effects of Exercise
- Health Systems, Economic Evaluations, Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmaceutical industry and healthcare
- Cardiovascular Syncope and Autonomic Disorders
- Esophageal Cancer Research and Treatment
- Patient-Provider Communication in Healthcare
- ECG Monitoring and Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
Indiana University – Purdue University Indianapolis
2020-2025
Indiana University School of Medicine
2020-2025
University of Mississippi Medical Center
2016-2023
Jackson Memorial Hospital
2016-2023
JA Toride Medical Center
2005-2023
University of Mississippi
2016-2022
Indiana University
2022
University School
2022
Indiana University Indianapolis
2020-2021
Suzuki (Japan)
2011-2018
<h3>Importance</h3> Shared decision-making (SDM) about anticoagulant treatment in patients with atrial fibrillation (AF) is widely recommended but its effectiveness unclear. <h3>Objective</h3> To assess the extent to which use of an SDM tool affects quality and decisions at-risk AF. <h3>Design, Setting, Participants</h3> This encounter-randomized trial recruited nonvalvular AF who were considering starting or reviewing their clinicians at academic, community, safety-net medical centers...
Inflammation markers and metabolic syndrome (MetS) are associated with risk of congestive heart failure (CHF). We evaluated whether combining inflammation MetS provided additive information for incident CHF if incorporating to the definition added prognostic information.We studied 4017 men women > or =65 years old, without baseline diabetes, participating in Cardiovascular Health Study, an observational study 12.2 follow-up 966 cases CHF. Baseline "C-reactive protein (CRP)-MetS" "interleukin...
Dilated cardiomyopathy (DCM) with severe mitral regurgitation (MR) and left bundle branch block (LBBB) typically indicates cardiac resynchronization therapy (CRT). However, device-related complications can limit CRT's applicability in some patients. A 77-year-old woman DCM, MR, LBBB underwent valve transcatheter edge-to-edge repair (M-TEER) because of high risk for CRT-related complications. Post-procedure, she showed marked improvement symptoms, ventricular function, QRS duration. This case...
Abstract Background Concurrent patent foramen ovale (PFO) and pulmonary arteriovenous malformation (PAVM) are rare but can cause paradoxical embolism platypnea-orthodeoxia syndrome (POS). Case Summary A 72-year-old female with embolic stroke history developed positional dyspnea. Evaluation revealed right-to-left shunting through PFO PAVM in the right middle lobe. Orthodeoxia was confirmed by 6% SpO2 decrease upon position change. staged approach adopted: closure Amplatzer™ Occluder, followed...
Abstract Background Mitral valve transcatheter edge-to-edge repair (M-TEER) with MitraClip® has become an established treatment for high-risk patients mitral regurgitation (MR). While device-related complications are known, they typically occur during leaflet grasping or after deployment, most issues arising from device-tissue interaction. Case Summary A 67-year-old woman dilated cardiomyopathy underwent M-TEER severe functional MR. Although resistance was noted initial device preparation...
Background Time to peak velocity ( TPV ) is an echocardiographic variable that can be easily measured and reflects a late peaking murmur, classic physical finding suggesting severe aortic stenosis AS ). The aim of this study was investigate the usefulness evaluate severity. Methods Results This included 700 patients, whose valve area AVA <1.5 cm 2 , 200 control patients. defined as time from opening when flow across reaches its peak. severity classified follows: High gradient mean...
Prior studies have shown insulin resistance is associated with reduced cardiac autonomic function measured at rest, but few determined whether during daily activities.We examined older adults without diabetes 48-h ambulatory electrocardiography (n = 759) in an ancillary study of the Atherosclerosis Risk Communities Study. Insulin resistance, exposure, was defined by quartiles for three indexes: 1) homeostatic model assessment (HOMA-IR), 2) triglyceride and glucose index (TyG), 3) to...
Background Guidelines promote shared decision-making (SDM) for anticoagulation in patients with atrial fibrillation. We recently showed that adding a within-encounter SDM tool to usual care (UC) increases patient involvement and clinician satisfaction, without affecting encounter length. aimed estimate the extent which use of an changed adherence decided plan clinical safety end points. Methods Results conducted multicenter, encounter-level, randomized trial assessing efficacy UC versus...
We evaluate associations of metabolic syndrome (MetS), C-reactive protein (CRP), and a CRP-incorporated definition MetS (CRPMetS) with risk all-cause mortality in biracial population.
Increased resting heart rate is associated with worse outcomes in studies of mostly white populations, but its significance not well established African Americans persons whose cardiac comorbidities and structural abnormalities differ.To study the prognostic utility a community-based American cohort Jackson Heart Study.A total 5261 participants Study, prospective, Jackson, Mississippi, were evaluated. Baseline was assessed by quintiles as continuous variable. All baseline documented 12-lead...
Enlargement of the proximal aorta is associated with aortic wall tissue remodeling, including fragmentation elastin fibers, increased synthesis collagen, and calcification, all which are stiffening. We hypothesized that diameter (AoD) cardiovascular events in a community-based cohort blacks.We investigated associations between AoD among 3018 black participants (mean age, 55.9 years; 69% women) without past history disease Jackson Heart Study. was measured using echocardiography at level...
The left ventricles of both rabbits and humans express predominantly beta-myosin heavy chain (MHC). Transgenic (TG) expressing 40% alpha-MHC are protected against tachycardia-induced cardiomyopathy, but the normal amount expressed in is only 5% to 7% its functional importance questionable. This study was undertaken identify a myofilament-based mechanism underlying cardiomyopathy protection extrapolate impact MHC isoform variation on myofilament function human hearts.Papillary muscle strips...
<h3>Importance</h3> How patients with atrial fibrillation (AF) and their clinicians consider cost in forming care plans remains unknown. <h3>Objective</h3> To identify factors that inform conversations regarding costs of anticoagulants for treatment AF between outcomes associated these conversations. <h3>Design, Setting, Participants</h3> This cohort study recorded encounters participant surveys at 5 US medical centers (including academic, community, safety-net centers) from the SDM4AFib...
Background Sudden cardiac death (SCD) is associated with severe coronary heart disease in the great majority of cases. Whether carotid intima‐media thickness (C‐IMT), a known surrogate marker subclinical atherosclerosis, risk SCD general population remains unknown. The objective this study was to investigate association between C‐IMT and SCD. Methods Results We examined total 20 862 participants: 15 307 participants ARIC (Atherosclerosis Risk Communities) 5555 CHS (Cardiovascular Health...