A5055766253- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Wind and Air Flow Studies
- Hydraulic and Pneumatic Systems
- Patient-Provider Communication in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Aerodynamics and Acoustics in Jet Flows
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Pharmaceutical industry and healthcare
- Atrial Fibrillation Management and Outcomes
- Vehicle Noise and Vibration Control
- Aquatic and Environmental Studies
- Effects of Vibration on Health
- Engineering Education and Technology
- Ethics in Clinical Research
- COVID-19 Impact on Reproduction
- Cellular and Composite Structures
- Antibiotics Pharmacokinetics and Efficacy
- Augmented Reality Applications
- Psychological and Educational Research Studies
- 3D Printing in Biomedical Research
- Intensive Care Unit Cognitive Disorders
Nottingham Trent University
2018-2022
Griffith University
2016-2018
University of Hertfordshire
2002
Over the past decade, use of AR has significantly increased over a wide range applications. Although there are many good examples technology being used in engineering, retail, and for entertainment, not been widely adopted teaching university engineering departments. It is generally accepted that can complement students’ learning experience by improving engagement helping to visualise complex physics; however, several key challenges still have be addressed fully integrate into broader...
Background Guidelines promote shared decision-making (SDM) for anticoagulation in patients with atrial fibrillation. We recently showed that adding a within-encounter SDM tool to usual care (UC) increases patient involvement and clinician satisfaction, without affecting encounter length. aimed estimate the extent which use of an changed adherence decided plan clinical safety end points. Methods Results conducted multicenter, encounter-level, randomized trial assessing efficacy UC versus...
Implantation of a rotary blood pump (RBP) can cause non-physiological flow fields in the left ventricle (LV) which may trigger thrombosis. Different inflow cannula geometry affect LV fields. The aim this study was to determine effect on intraventricular under full support patient specific model.Computed tomography angiography imaging performed RBP candidate develop patient-specific model. Five cannulae were evaluated, modelled those used clinically or development. are described as crown like...
Rotary left ventricular assist devices (LVADs) are commonly operated at a constant speed, attenuating blood flow pulsatility. Speed modulation of rotary LVADs has been demonstrated to improve vascular pulsatility and pump washout. The effect LVAD speed on intraventricular dynamics is not well understood, which may have an influence thromboembolic events. This study aimed numerically evaluate characteristics with modulated LVAD. A severely dilated anatomical ventricle was supported by...
Engineered tissues provide an alternative to graft material, circumventing the use of donor tissue such as autografts or allografts and non-physiological synthetic implants. However, their lack vasculature limits growth volumetric more than several millimeters thick which success post-implantation. Perfused bioreactors enhance nutrient mass transport inside lab-grown but remain poorly customizable support culture personalized Here, a multiscale framework computational fluid dynamics (CFD),...
Abstract Background Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related thrombosis. This study aimed understand the risks of thrombosis variations in implanted device orientation. A severely dilated pulsatile patient-specific ventricle, modelled computational fluid dynamics, was utilised identify risk for five cannulation angles. With respect inflow cannula axis directed towards mitral valve, other angles were 25° and 20°...
<h3>Importance</h3> How patients with atrial fibrillation (AF) and their clinicians consider cost in forming care plans remains unknown. <h3>Objective</h3> To identify factors that inform conversations regarding costs of anticoagulants for treatment AF between outcomes associated these conversations. <h3>Design, Setting, Participants</h3> This cohort study recorded encounters participant surveys at 5 US medical centers (including academic, community, safety-net centers) from the SDM4AFib...
Polyurethane foams have unique properties that make them suitable for a wide range of applications, including cushioning and seat pads. The foam mechanical largely depend on both the parent material cell microstructure. Uniaxial loading experiments, X-ray tomography finite element analysis can be used to investigate relationship between macroscopic microscopic structure. specimens were scanned using computed tomography. geometries converted three-dimensional (3D) CAD models open source,...
The flow regime around a hexagonal polygon with low Reynolds numbers Re < 200 is numerically investigated in two different orientations namely face- and corner oriented. basic characteristics, including drag coefficient, lift Strouhal number critical of the cylinders, are calculated by solving Navier–Stokes mass conservation (continuity) equations, using Simple (semi-implicit method for pressure-linked equations) algorithm. Within studied range Re, predicted coefficient face-oriented...
Abstract There are many practical situations when jets emanating from non‐axis‐symmetric apertures, yet numerical simulations of such three‐dimensional scarce and most them have failed to reproduce some the unique flow features. Examples this type gas leaks flanges. These can be treated as issuing high aspect ratio rectangular orifices. The present work consists a series large eddy typifying using different inflow boundary conditions. Good agreement with available experiments was observed...
<title>Abstract</title> Immunotherapy has revolutionised cancer treatment, yet few patients respond clinically, necessitating alternative strategies that can benefit these patients. Novel immune-oncology targets achieve this through bypassing resistance mechanisms to standard therapies. To address this, we introduce MIDAS, a multimodal graph neural network system for target discovery leverages gene interactions, multi-omic patient profiles, immune cell biology, antigen processing, disease...
Design methods for large industrial pumps are well developed, but they cannot be relied upon when designing specialised miniature pumps, due to scaling issues. Therefore, the design and development phase of small demand numerous experimental tests ensure a viable prototype. Of initial interest is hydraulic in form pump performance efficiency curves. This project aimed produce an automated test rig capable generating both (P-Q - pressure vs. flow rate) curves that reliable repeatable. The...
Abstract Background Trial recruitment of Black, indigenous, and people color (BIPOC) is key for interventions that interact with socioeconomic factors cultural norms, preferences, values. We report on our experience enrolling BIPOC participants into a multicenter trial shared decision-making intervention about anticoagulation to prevent strokes, in patients atrial fibrillation (AF). Methods enrolled AF their clinicians 5 healthcare systems (three academic medical centers, an urban/suburban...
Repeated High-G shocks and whole-body vibration (WBV) can increase the risk of fatigue injuries in lumbar region spine for crew passengers on high-speed craft (HSC). Existing reviews have suggested beneficial effects abdominal belts regarding torso stabilization spinal unloading. The paper provides a novel 3D seated human model with virtual belt to simulate occupants HSC. is built AnyBody, commercial software musculoskeletal simulation based inverse dynamics method. behaves like an...