A5045656058- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Erythrocyte Function and Pathophysiology
- Mesenchymal stem cell research
- Reconstructive Facial Surgery Techniques
- Hematopoietic Stem Cell Transplantation
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Anatomy and Medical Technology
- Cancer Cells and Metastasis
- Nasal Surgery and Airway Studies
- Cell Image Analysis Techniques
- Blood properties and coagulation
- COVID-19 Impact on Reproduction
- CAR-T cell therapy research
- Essential Oils and Antimicrobial Activity
- Pregnancy and preeclampsia studies
- Ear Surgery and Otitis Media
- Coronary Interventions and Diagnostics
- Cellular Mechanics and Interactions
- Ethnobotanical and Medicinal Plants Studies
- Pancreatic function and diabetes
- Prosthetics and Rehabilitation Robotics
The University of Queensland
2021-2025
Queensland University of Technology
2019-2024
BioMimetic Systems (United States)
2023
Imperial College London
2012-2021
Queensland Health
2020
Transnational Press London
2018
Pepperdine University
2015-2016
Abstract The field of melt electrowriting (MEW) has seen significant progress, bringing innovative advancements to the fabrication biomaterial scaffolds, and creating new possibilities for applications in tissue engineering beyond. Multidisciplinary collaboration across materials science, computational modeling, AI, bioprinting, microfluidics, dynamic culture systems offers promising opportunities gain deeper insights into complex biological systems. As focus shifts towards personalized...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as 'preeclampsia-like syndrome'. However, the mechanisms underpinning SARS-CoV-2-induced malfunction are still unclear. Here, we investigated whether transcriptional architecture placenta altered response SARS-CoV-2 infection.
Auxetics are an interesting class of materials that expand in transverse directions when tensile loading is applied. For example, contrast to conventional materials, auxetic tube will increase diameter stretched along its axis. To date, tubular scaffolds have been proposed for applications tissue engineering and soft robotics; however, they not yet routinely produced precisely-engineered microfibre structures using the melt electrowriting additive manufacturing method. Using a custom device...
Abstract This paper proposes a fully automatic method to segment the inner boundary of bony orbit in two different image modalities: magnetic resonance imaging (MRI) and computed tomography (CT). The method, based on deep learning architecture, uses convolutional neural networks series followed by graph-search generate for orbit. When compared human performance segmentation both CT MRI data, proposed achieves high Dice coefficients background, with scores 0.813 0.975 images 0.930 0.995...
Abstract Additive manufacturing via melt electrowriting (MEW) can create ordered microfiber scaffolds relevant for bone tissue engineering; however, there remain limitations in the adoption of new printing materials, especially MEW biomaterials. For example, while promising composite formulations polycaprolactone with strontium‐substituted bioactive glass have been processed into large or disordered fibres, from what is known, biologically‐relevant concentrations (>10 wt%) never printed...
Melt electrowriting (MEW) is an additive manufacturing technique capable of fabricating microfibre thermoplastic scaffolds that growing in popularity for tissue engineering applications. MEW able to produce micron-scale biocompatible constructs through electrodynamic jet deposition with a high level control over fibre deposition. By depositing fibres on rotating cylindrical collector (mandrel), tubular can be fabricated mimic anatomical tissues such as blood vessels. This proof-of-concept...
Abstract Computational fluid dynamics (CFD) simulations are increasingly utilised to evaluate intracranial aneurysm (IA) haemodynamics aid in the prediction of morphological changes and rupture risk. However, these models vary differences published results warrant investigation IA-CFD reproducibility. This study aims explore sources intra-team variability determine its impact on morphology CFD parameters. A team four operators were given six sets magnetic resonance angiography data spanning...
In vitro culture processes supporting the simultaneous formation of vessel networks alongside differentiation towards mature parenchymal tissue have numerous clinical and agricultural applications but remain unrealised due to contrasting requirements. Of specific interest is lab-grown vascularised adipose study metabolic syndrome, diabetes, obesity, cardiovascular diseases, advance cultivated meat technologies. We report a microfluidic 3D hydrogel device capable live-imaging fluorescent...
Vessel forming assays are a valuable in vitro technology to evaluate the vasculogenic and angiogenic potential of different cell types, matrix proteins, soluble factors. Recent advances high-content microscopy allow for vascular morphogenesis be captured real-time high-throughput screening purposes. Unfortunately, existing microvascular network quantification algorithms either inaccurate, not user-friendly, or manually analyse one image at time, unfavourable applications. This manuscript...
Intracranial aneurysms (IAs) are present in 2-6% of the global population. While rare, rupture results mortality rates 30-50% and lifelong disabilities survivors. treatment unruptured IAs carries its own risk mortality, there no rigid guidelines indicating which IA presentation is at greater rupture. We develop evaluate suitability various additive manufacturing processes to fabricate patient-specific culture models for understanding pathophysiology thereby support future development a...
Abstract Big mechanically-active culture systems (BigMACS) are promising to stimulate, control, and pattern cell tissue behaviours with less soluble factor requirements. However, it remains challenging predict if how distributed mechanical forces impact single-cell tissue. In this study, we introduce a tissue-scale finite element analysis (FEA) framework able correlate sub-cellular quantitative histology centimetre-scale biomechanics. Our is relevant diverse BigMACS, including media...
Pancreatic ductal adenocarcinoma is an aggressive disease with extremely low survival rate. This due to the (i) poor prognosis and (ii) high resistance of current treatment options. The latter partly very complex dense tissue/tumour microenvironment pancreatic cancer, which contributes disease's progression inhibition apoptotic pathways. Over last years, advances in tissue engineering development three-dimensional (3D) culture systems have shed more light into cancer research by enabling a...
Abstract Purpose Three‐dimensional (3D) facial scanning is an emerging clinical tool to capture external anatomical features for quantitative assessment and treatment in a wide range of settings. Materials Methods In this study, economical approach rapid faces the clinic was developed validated record valuable 3D patient data using smartphone cameras photogrammetry software. Five novice operators were recruited watch instructional video on technique before 20 healthy adult participants....
A series of novel three-dimensional (3D) nanotemplates which have tuned surface mesoporosity and chemistry based on the protein interest been developed to facilitate crystallization. The crystallization five model proteins systems is reported at hereto lowest or precipitant concentrations. These improvements were only possible due combined use optimum pore sizes with appropriate chemistries in preparation 3D nanotemplates. success this strategy can be ascribed specific design ordered are...
Biomimetic materials are essential for the production of clinically relevant bone grafts tissue engineering applications. Their ability to modulate stem cell proliferation and differentiation can be used harness regenerative potential those cells optimize efficiency engineered grafts. The arginyl-glycyl-aspartic acid (RGD) peptide has been recognized as adhesion motif various extracellular matrix proteins affect behaviour in biomaterials. Attempts functionalize biomaterials with RGD have...
The fabrication of patient-specific scaffolds for bone substitutes is possible through extrusion-based 3D printing calcium phosphate cements (CPC) which allows the generation structures with a high degree customization and interconnected porosity. Given brittleness this clinically approved material, stability open-porous cannot always be secured. Herein, multi-technological approach allowed simultaneous combination CPC melt electrowriting (MEW) polycaprolactone (PCL) microfibers in an...
Engineered tissues provide an alternative to graft material, circumventing the use of donor tissue such as autografts or allografts and non-physiological synthetic implants. However, their lack vasculature limits growth volumetric more than several millimeters thick which success post-implantation. Perfused bioreactors enhance nutrient mass transport inside lab-grown but remain poorly customizable support culture personalized Here, a multiscale framework computational fluid dynamics (CFD),...