A5020014937- Protease and Inhibitor Mechanisms
- Wound Healing and Treatments
- COVID-19 Impact on Reproduction
- Prostate Cancer Treatment and Research
- Pregnancy and preeclampsia studies
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Radiopharmaceutical Chemistry and Applications
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Bone health and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pressure Ulcer Prevention and Management
- Periodontal Regeneration and Treatments
- Gestational Diabetes Research and Management
- Nanoparticles: synthesis and applications
- Burn Injury Management and Outcomes
- Pregnancy and Medication Impact
- Cell Image Analysis Techniques
- Cellular Mechanics and Interactions
- Cellular transport and secretion
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- COVID-19 and healthcare impacts
Queensland University of Technology
2019-2024
Bond University
2023-2024
Prostate Cancer Foundation of Australia
2021
Translational Research Institute
2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as 'preeclampsia-like syndrome'. However, the mechanisms underpinning SARS-CoV-2-induced malfunction are still unclear. Here, we investigated whether transcriptional architecture placenta altered response SARS-CoV-2 infection.
In vitro engineering of a bone metastases model allows us to study the effects antiandrogens in advanced prostate cancer.
While stromal interactions are essential in cancer adaptation to hormonal therapies, the effects of bone stroma and androgen deprivation on progression poorly understood. Here, we tissue-engineered validated an vitro microtissue model osteoblastic metastases, used it study this microenvironment. The was established by culturing primary human osteoprogenitor cells melt electrowritten polymer scaffolds, leading a mineralized osteoblast-derived containing, 3D setting, viable cells, osteocytic...
Macrophage migration into injured or infected tissue is a key aspect in the pathophysiology of many diseases where inflammation driving factor. Membrane-type-1 matrix metalloproteinase (MT1-MMP) cleaves extracellular components to facilitate invasion. Here we show that, unlike constitutive MT1-MMP surface recycling seen cancer cells, unactivated macrophages express low levels MT1-MMP. Upon lipopolysaccharide (LPS) activation, synthesis dramatically increases 10-fold at by 15 hours....
Abstract Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution PSA) associated reduced risk, however, functional relevance unknown. Here, we identify that SNP variant-induced change PSA biochemical activity mediates pathogenesis. ‘Thr’ variant leads to small subcutaneous tumours, supporting risk. However, also displays higher metastatic...
ABSTRACT Objectives Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as “preeclampsia-like syndrome”. However, the mechanisms underpinning SARS-CoV-2-induced malfunction are still unclear. Here, we investigated whether transcriptional architecture placenta altered response SARS-CoV-2 infection. Methods We utilized whole-transcriptome, digital spatial profiling,...