A5076571268- Listeria monocytogenes in Food Safety
- 3D Printing in Biomedical Research
- Microbial Inactivation Methods
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- thermodynamics and calorimetric analyses
- Acute Myeloid Leukemia Research
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Mathematical Biology Tumor Growth
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Radiation Therapy and Dosimetry
- Circadian rhythm and melatonin
- Advanced Sensor and Energy Harvesting Materials
- Meat and Animal Product Quality
- Electrospun Nanofibers in Biomedical Applications
- Blood properties and coagulation
- Chronic Myeloid Leukemia Treatments
- Advanced Chemical Sensor Technologies
- Mass Spectrometry Techniques and Applications
- Cell Image Analysis Techniques
- Erythrocyte Function and Pathophysiology
- Graphene and Nanomaterials Applications
University College London
2021-2025
University of Surrey
2015-2024
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2023
Guildford Hospital
2017-2019
University of Memphis
2018
Texas A&M University
2018
Louisiana State University Health Sciences Center New Orleans
2018
John Wiley & Sons (United States)
2018
Smith College
2018
Syracuse University
2018
We report the development and validation of an untargeted single-cell lipidomics method based on microflow chromatography coupled to a data-dependent mass spectrometry for fragmentation-based identification lipids. Given absence lipid standards, we show how methodology should be optimized validated using dilute cell extract. The is applied pancreatic cancer macrophage extracts standards demonstrate sensitivity requirements confident assignment lipids classification type at level. then system...
Mechanism-switchable nanomotors are expected to exhibit high adaptability and wide applicability. Herein, for the first time, we report a flask-shaped carbon@Pt@fatty-acid nanomotor with light-induced switch between nonionic self-diffusiophoresis bubble propulsion. This is fabricated through superassembly of platinum nanoparticles on surface carbon nanobottles, fatty acids infused into cavity nanobottles serve as light-sensitive switch. Such can be propelled via catalytic decomposition H2O2...
Efficient and site-specific delivery of therapeutics drugs remains a critical challenge in cancer treatment. Traditional drug nanocarriers such as antibody-drug conjugates are not generally accessible due to their high cost can lead serious side effects including life-threatening allergic reactions. Here, these problems overcome via the engineering supramolecular agents that manufactured with an innovative double imprinting approach. The developed molecularly imprinted nanoparticles...
The objective of the present study was to validate a kinetic model for growth spoilage bacteria in modified atmosphere packed (MAP) gilthead seabream fillets and select Time Temperature Integrator (TTI). temperature CO2 dependence lactic acid MAP expressed by an Arrhenius-type range 0–15 °C 20–80% CO2, which validated at isothermal, variable chill chain conditions. A new UV activatable photochemical TTI, kinetically studied influence level activation on response TTI modelled. Applying...
With a very low survival rate, pancreatic ductal adenocarcinoma (PDAC) is deadly disease. This has been primarily attributed to – (i) its late diagnosis and (ii) high resistance current treatment methods. The later, specifically requires the development of robust, realistic in vitro models PDAC, capable accurately mimicking vivo tumour niche. Advancements field Tissue Engineering (TE) have helped such for PDAC. Herein, we report first time novel hybrid, poly- urethane (PU) scaffold based,...
Calcium phosphate glasses are a promising new generation of biomaterials that can simultaneously induce tissue regeneration and controlled release therapeutic molecules. In this work, novel calcium containing 0, 2, 4, 6 mol % Cu2+ were synthesized via room temperature precipitation reaction in aqueous solution. The effect addition on the glass properties structure was investigated using thermal analysis, 31P solid-state MAS NMR, Raman spectroscopy, X-ray diffraction. All crystallize at >500...
Ultrasound, alone or in combination with natural antimicrobials, is a novel food processing technology of interest to replace traditional decontamination methods, as it milder than classical sterilisation (heat treatment) and maintains desirable sensory characteristics. However, ultrasound efficacy can be affected by structure/composition, well the order which combined treatments are applied. More specifically, target different cell components could result enhanced inactivation if applied...
Being nondegradable, vinyl polymers have limited biomedical applicability. Unfortunately, backbone esters incorporated through conventional radical ring-opening methods do not undergo appreciable abiotic hydrolysis under physiologically relevant conditions. Here, PEG acrylate and di(ethylene glycol) acrylamide-based copolymers containing thioesters were prepared the copolymerization of thionolactone dibenzo[c,e]oxepin-5(7H)-thione. The degraded fully in presence 10 mM cysteine at pH 7.4,...
In this work, we demonstrate the development and first application of nanocapillary sampling followed by analytical flow liquid chromatography-mass spectrometry for single-cell lipidomics. Around 260 lipids were tentatively identified in a single cell, demonstrating remarkable sensitivity. Human pancreatic ductal adenocarcinoma cells (PANC-1) treated with chemotherapeutic drug gemcitabine can be distinguished from controls solely on basis their lipid profiles. Notably, relative abundance...
Pancreatic ductal adenocarcinoma is an aggressive disease with extremely low survival rate. This due to the (i) poor prognosis and (ii) high resistance of current treatment options. The latter partly very complex dense tissue/tumour microenvironment pancreatic cancer, which contributes disease's progression inhibition apoptotic pathways. Over last years, advances in tissue engineering development three-dimensional (3D) culture systems have shed more light into cancer research by enabling a...
Angiogenesis, the formation of new capillaries from existing ones, is a fundamental process in regenerative medicine and tissue engineering. While it known to be affected by circadian rhythms
Pancreatic ductal adenocarcinoma (PDAC) is a challenge for global health with very low survival rate and high therapeutic resistance. Hence, advanced preclinical models treatment screening are of paramount importance. Herein, chemotherapeutic (gemcitabine) assessment on novel (polyurethane) scaffold-based spatially 3D multicellular PDAC carried out. Through comprehensive image-based analysis at the protein level, expression mRNA importance stromal cells confirmed, primarily activated...