A5033252599- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- biodegradable polymer synthesis and properties
- Quantum Chromodynamics and Particle Interactions
- Facial Trauma and Fracture Management
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Particle Detector Development and Performance
- Orthopaedic implants and arthroplasty
- Dark Matter and Cosmic Phenomena
- Additive Manufacturing and 3D Printing Technologies
- Laser-Ablation Synthesis of Nanoparticles
- Rheology and Fluid Dynamics Studies
- Osteoarthritis Treatment and Mechanisms
- 3D Printing in Biomedical Research
- Bone health and osteoporosis research
- Calcium Carbonate Crystallization and Inhibition
- Tissue Engineering and Regenerative Medicine
- Collagen: Extraction and Characterization
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Silicone and Siloxane Chemistry
Imperial College London
2016-2025
Institute for Molecular Medicine
2023
Intel (United States)
2003-2022
University of California, Los Angeles
2022
Transnational Press London
2014-2020
University College London
2006-2019
Kensington Health
2000-2018
The London College
2016
University of Ioannina
2014
Heriot-Watt University
2013
This paper looks at a class of mechanisms that change structure when erected or folded. The includes variety artefacts and decorative gifts boxes comprised flat card creased to enable the folding unfolding structure. Such admits kinematic study in keeping with theory creases are treated as hinges joining panels links. New horizons have been brought up use mechanised manufacture this kind. Here typical types described terms their fundamental parts equivalent mechanisms. Screw system is into...
Abstract Effects of powder type, particle size (5–20 μm; 90–300 90–710 μm), and type dissolution medium on the behavior bioactive glasses were investigated in vitro using melt‐derived 45S5 sol‐gel derived 58S glass powders. Dissolution studies performed simulated body fluid α‐MEM based cell culture at 37°C under dynamic conditions (1 Hz) for periods 30 min, 1, 2, 4, 8, 17, 22 h. The concentrations elements dissolved from evaluated inductively coupled plasma analysis. reacted powders analyzed...
Bioactive glasses are known to have the ability regenerate bone, but their use has been restricted mainly powder, granules, or small monoliths. This work reports on development of sol-gel foams with potential applications as bone graft implants templates for in vitro synthesis tissue transplantation. These bioactive exhibit a hierarchical structure interconnected macropores (10-500 microm) and mesoporous framework typical gel-glasses (pores 2-50 nm). The macroporous matrixes were produced...
Abstract The ability of bioactive glasses to form a bond living bone and also stimulate bone‐cell proliferation depends on the chemical composition surface texture glasses. In this work, differences in physical properties between melt‐derived 45S5 sol‐gel–derived 58S Bioglass® powders various particle‐size ranges were studied. characterized for distribution by laser spectrometry, specific area porosity nitrogen sorption analysis, morphological features scanning electron microscopy....
Glass caused a revolution in health care when Bioglass was discovered by Larry Hench. It the first material to bond with bone, rather than be encapsulated fibrous tissue, launching field of bioactive ceramics. is also biodegradable. Almost 50 years on from its discovery that continues. Bioactive glasses stimulate more bone regeneration other ceramics, which attributed their dissolution products stimulating cells at genetic level. This second has changed way clinicians, scientists, and...
Increasing cell survival in stem therapy is an important challenge for the field of regenerative medicine.Here, we report theranostic mesoporous silica nanoparticles that can increase through both diagnostic and therapeutic approaches.First, nanoparticle offers ultrasound MRI signal to guide implantation into peri-infarct zone away from most necrotic tissue.Second, serves as a slow release reservoir insulin-like growth factor (IGF)-a protein shown survival.Mesenchymal cells labeled with...
Sol–gel derived bioactive glasses (70 mol% SiO2 and 30 CaO) have high potential as materials for bone regeneration devices sustained drug delivery. They bond to a controllable degradation rate. unique tailorable nanoporosity, which enhances their surface area exposes hydroxyl groups affects protein adsorption cellular response. This study aims fully characterise the evolution of nanoporous structure sol–gel glass first time, understand its nanostructure control, so that with specific...
Bioactive glasses react chemically with body fluids in a manner that is compatible the repair processes of tissues. This results formation an interfacial bond between and living tissue. also stimulate bone-cell proliferation. behavior dependent on chemical composition as well surface texture glasses. It has been recently reported gel-derived monolith specimens binary SiO2 - CaO are bioactive over similar molar range content previously studied ternary CaO-P2O5-SiO2 system. In this report,...
Abstract Nature has evolved mechanisms to create a diversity of specialized materials through nanoscale organization. Inspired by nature, hybrid are designed with highly tailorable properties, which achieved careful control their interactions. These novel materials, based on silica‐gelatin system, have the potential serve as platform technology for human tissue regeneration. Covalent interactions between inorganic and organic constituents essential enable precise mechanical dissolution...
Abstract The effect of glass dosage (0.001 g ml −1 to 0.015 ) on the in vitro dynamic dissolution behavior melt‐derived 45S5 and sol‐gel–derived 58S bioactive glasses, simulated body fluid (SBF) at 37 °C, was evaluated. These glasses differ significantly texture, especially specific surface area porosity, as a result differences manufacturing route. concentrations elements (Si, Ca, P, Na) leached from into medium, 1 22 h, were evaluated with use induced coupled plasma analysis (ICP). reacted...
Bioactive glasses are able to bond bone through the formation of hydroxy-carbonate apatite in body fluids while strontium (Sr)-releasing bioactive interest for patients suffering from osteoporosis, as Sr was shown increase both vitro and vivo . A melt-derived glass series (SiO 2 –P O 5 –CaO–Na O) with 0–100% calcium (Ca) replaced by on a molar base prepared. pH change, ion release during immersion powder simulated fluid Tris buffer at 37°C over up 8 h were investigated showed that...